Praziquantel

Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

The first single dose of praziquantel (Pra) was given ig to mice on the day of infection with Schistosoma japonicum cercariae, or 7 d, 14 d, and 21 d after infection. Afterwards, the same dose of Pra was given once at 1-3 wk intervals for 2-3 times. The prophylactic effect was estimated by the reduction of average number of total and female worms, the number of mice without female worm, and the gross change of the liver.

Author(s): 
Xiao, S. H.
You, J. Q.
Mei, J. Y.
Jiao, P. Y.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

Artemether (Art, beta-methyl ether of artemisinin) first synthesized by Shanghai Institute of Materia Medica, Chinese Academy of Sciences, is effective against not only malaria but also schistosomiasis. When rabbits infected with Schistosoma japonicum cercariae for 7 d were treated ig with Art 10 mg.kg-1, the total worm reduction rates were 74.6-76.7%. If Art (10 mg.kg-1) was given once weekly after the first treatment for 3-4 times, the total worm reduction rate was > 98%, and most of the rabbits were free from female worms.

Author(s): 
Xiao, S. H.
You, J. Q.
Mei, J. Y.
Jiao, P. Y.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

To study the histopathological change of the liver of the hosts treated with artemether (Art) or praziquantel (Pra) in early stage after infection with Schistosoma japonicum cercariae. METHODS: Dogs infected once with schistosome cercariae were treated ig with Art 10 mg.kg-1 or Art capsule (ArtC) 15 mg.kg-1 on d 7, or praziquantel (Pra) 30-40 mg.kg-1 on d 21 after infection, followed by the repeated dosing once every 1 or 2 wk for 2-4 times.

Author(s): 
Xiao, S. H.
Yang, Y. Q.
Zhang, C. W.
You, J. Q.
Publication Title: 
Tropical medicine & international health: TM & IH

The first choice for treatment of Clonorchis sinensis infections is praziquantel. Experimental data suggest that artemisinin derivatives are active against C. sinensis. The efficacy of both drugs against clonorchiasis was evaluated in a pilot study in clonorchiasis patients in an endemic area in the North of Vietnam. Twenty-one patients received praziquantel 25 mg/kg o.d. for three days, the regular regimen in that area, and 21 patients were treated with artemisinin 500 mg b.i.d. for 5 days. Faecal egg counts were performed before as well as 6 days and 5 weeks after treatment.

Author(s): 
Tinga, N.
De, N.
Vien, H. V.
Chau, L.
Toan, N. D.
Kager, P. A.
Vries, P. J.
Publication Title: 
Tropical medicine & international health: TM & IH

A group of 110 individuals with Schistosoma mansoni infection was investigated. Patients were allocated to one of three treatment groups and given artesunate or praziquantel alone or both in combination. Combined artesunate-praziquantel significantly increased the number of individuals cured at 5 weeks post-treatment, but at 12 weeks was only better than artesunate alone and at 24 weeks there was no statistically significant difference between the three groups. Egg count reduction rate was similar to the rate obtained with praziquantel used alone.

Author(s): 
De Clercq, D.
Vercruysse, J.
Verlé, P.
Kongs, A.
Diop, M.
Publication Title: 
The Journal of Infectious Diseases

Recently, artemisinin derivatives have been shown to be efficacious in chemoprophylaxis of and chemotherapy for Schistosoma japonicum and S. mansoni infections. Therefore, a double-blind, randomized, placebo-controlled study was carried out to investigate the efficacy and tolerability of artesunate plus placebo and the combination of artesunate and praziquantel in the treatment of S. haematobium infections in Gabon.

Author(s): 
Borrmann, S.
Szlezák, N.
Faucher, J. F.
Matsiegui, P. B.
Neubauer, R.
Binder, R. K.
Lell, B.
Kremsner, P. G.
Publication Title: 
Antimicrobial Agents and Chemotherapy

We examined the effects of praziquantel and the artemisinins on adult Echinostoma caproni. In vitro, both praziquantel and the artemisinins exhibited exposure-response relationships. In vivo, worm burden reductions of 100% were achieved with single oral doses of praziquantel, artesunate, and artemether at 50, 700, and 1,100 mg/kg of body weight, respectively.

Author(s): 
Keiser, Jennifer
Brun, Reto
Fried, Bernard
Utzinger, Jürg
Publication Title: 
Bulletin of the World Health Organization

OBJECTIVE: To evaluate the safety and efficacy of combining artemether (AM) and praziquantel (PZQ) in different regimens for treating acute schistosomiasis japonica. METHODS: We undertook a randomized, double-blind, placebo-controlled trial within four specialized schistosomiasis hospitals in the Dongting Lake region, Hunan province, China, between May 2003 and December 2005.

Author(s): 
Hou, Xun-Ya
McManus, Donald P.
Gray, Darren J.
Balen, Julie
Luo, Xin-Song
He, Yong-Kang
Ellis, Magda
Williams, Gail M.
Li, Yue-Sheng
Publication Title: 
Antimicrobial Agents and Chemotherapy

Caused by the Chinese liver fluke Clonorchis sinensis, clonorchiasis is of growing public health importance. Treatment and control of the disease rely on a single drug, praziquantel, and little information regarding combination chemotherapy is available. Here, we evaluated the in vivo efficacy of praziquantel combined with artemether, artesunate, OZ78, and tribendimidine, as well as an artesunate-tribendimidine combination against C. sinensis, in a rat model.

Author(s): 
Keiser, Jennifer
Xiao, Shu-Hua
Smith, Thomas A.
Utzinger, Jürg
Publication Title: 
PloS One

BACKGROUND: This study was conducted to determine the efficacy of the antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma haematobium in school aged children. METHODOLOGY/PRINCIPAL FINDINGS: The study was conducted in Djalakorodji, a peri-urban area of Bamako, Mali, using a double blind setup in which As+SMP was compared with praziquantel (PZQ). Urine samples were examined for Schistosoma haematobium on days -1, 0, 28 and 29.

Author(s): 
Sissoko, Mahamadou S.
Dabo, Abdoulaye
Traoré, Hamidou
Diallo, Mouctar
Traoré, Boubacar
Konaté, Drissa
Niaré, Boubacar
Diakité, Moussa
Kamaté, Bourama
Traoré, Abdrahamane
Bathily, Aboudramane
Tapily, Amadou
Touré, Ousmane B.
Cauwenbergh, Sarah
Jansen, Herwig F.
Doumbo, Ogobara K.

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