Premenopause

Publication Title: 
PloS One

BACKGROUND: A Mediterranean diet has a recognized beneficial effect on health and longevity, with a protective influence on several cancers. However, its association with breast cancer risk remains unclear. OBJECTIVE: We aimed to investigate whether adherence to a Mediterranean dietary pattern influences breast cancer risk. DESIGN: The Swedish Women's Lifestyle and Health cohort study includes 49,258 women aged 30 to 49 years at recruitment in 1991-1992. Consumption of foods and beverages was measured at enrollment using a food frequency questionnaire.

Author(s): 
Couto, Elisabeth
Sandin, Sven
Lˆf, Marie
Ursin, Giske
Adami, Hans-Olov
Weiderpass, Elisabete
Publication Title: 
Psychosomatic Medicine

BACKGROUND: Leukocyte telomere shortening can serve as a biomarker of aging, as telomere length (TL) can decline with age and shortening is positively associated with morbidity and mortality. It is therefore important to identify psychological and behavioral factors linked to accelerated telomere shortening. Stress and poorer metabolic health (greater adiposity, insulin resistance, and cortisol) correlate with shorter telomeres.

Author(s): 
Kiefer, Amy
Lin, Jue
Blackburn, Elizabeth
Epel, Elissa
Publication Title: 
Psychosomatic Medicine

OBJECTIVE: Excessive central fat puts one at greater risk of disease. In animal studies, stress-induced cortisol secretion has been shown to increase central fat. The objective of this study was to assess whether women with central fat distribution (as indicated by a high waist-to-hip ratio [WHR]), across a range of body mass indexes, display consistently heightened cortisol reactivity to repeated laboratory stressors.

Author(s): 
Epel, E. S.
McEwen, B.
Seeman, T.
Matthews, K.
Castellazzo, G.
Brownell, K. D.
Bell, J.
Ickovics, J. R.
Publication Title: 
Psychosomatic Medicine

BACKGROUND: Leukocyte telomere shortening can serve as a biomarker of aging, as telomere length (TL) can decline with age and shortening is positively associated with morbidity and mortality. It is therefore important to identify psychological and behavioral factors linked to accelerated telomere shortening. Stress and poorer metabolic health (greater adiposity, insulin resistance, and cortisol) correlate with shorter telomeres.

Author(s): 
Kiefer, Amy
Lin, Jue
Blackburn, Elizabeth
Epel, Elissa
Publication Title: 
Psychoneuroendocrinology

To date, there are few known predictors of stress-induced eating. The purpose of this study was to identify whether physiological and psychological variables are related to eating after stress. Specifically, we hypothesized that high cortisol reactivity in response to stress may lead to eating after stress, given the relations between cortisol with both psychological stress and mechanisms affecting hunger. To test this, we exposed fifty-nine healthy pre-menopausal women to both a stress session and a control session on different days.

Author(s): 
Epel, E.
Lapidus, R.
McEwen, B.
Brownell, K.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms of how stress gets "under the skin" remain elusive. We investigated the hypothesis that stress impacts health by modulating the rate of cellular aging.

Author(s): 
Epel, Elissa S.
Blackburn, Elizabeth H.
Lin, Jue
Dhabhar, Firdaus S.
Adler, Nancy E.
Morrow, Jason D.
Cawthon, Richard M.
Publication Title: 
Hormones and Behavior

Negative mood and stress are associated with cardiovascular and metabolic disease. There are likely many physiological mechanisms underlying the poor health outcomes. The relationship of psychological states (negative mood, life stress, and stress-responsive hormones) and adiponectin, an adipokine that promotes insulin sensitivity, was investigated in two separate studies. The two groups of participants included 52 healthy, premenopausal women, and 63 postmenopausal women with a range of stress levels.

Author(s): 
Adam, Tanja
Schamarek, Imke
Springer, Elizabeth A.
Havel, Peter J.
Epel, Elissa E.
Publication Title: 
The Journal of Nutrition, Health & Aging

OBJECTIVE: The decline in antioxidant defenses due to both estrogen loss and frequent adoption of poor dietary choices exposes postmenopausal women to cardiovascular diseases. Adequate nutrition and physical exercise are two factors of health promotion. This study investigated whether regular practice of mind-body exercise (yoga and/or tai chi) alters dietary intake and antioxidant status and balances the menopause-related increases in lipid peroxidation and cardiovascular risk. DESIGN: Cross-sectional study.

Author(s): 
Palasuwan, A.
Margaritis, I.
Soogarun, S.
Rousseau, A.-S.
Publication Title: 
The Journal of Nutrition, Health & Aging

OBJECTIVE: The decline in antioxidant defenses due to both estrogen loss and frequent adoption of poor dietary choices exposes postmenopausal women to cardiovascular diseases. Adequate nutrition and physical exercise are two factors of health promotion. This study investigated whether regular practice of mind-body exercise (yoga and/or tai chi) alters dietary intake and antioxidant status and balances the menopause-related increases in lipid peroxidation and cardiovascular risk. DESIGN: Cross-sectional study.

Author(s): 
Palasuwan, A.
Margaritis, I.
Soogarun, S.
Rousseau, A.-S.
Publication Title: 
Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology

Naturopathic physicians commonly make dietary and/or dietary supplement recommendations for breast cancer prevention. This placebo-controlled, parallel-arm, pilot study tested the effects of two naturopathic interventions over five menstrual cycles on sex steroid hormones and metabolic markers in 40 healthy premenopausal women.

Author(s): 
Greenlee, Heather
Atkinson, Charlotte
Stanczyk, Frank Z.
Lampe, Johanna W.

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