Principal Component Analysis

Publication Title: 
Journal of trace elements in medicine and biology: organ of the Society for Minerals and Trace Elements (GMS)

The potentially toxic metals content was determined in selected plants, used in Traditional Chinese Medicine (Angelica sinensis, Bacopa monnieri, Bupleurum sinensis, Curcuma longa, Cola accuminata, Emblica officinalis, Garcinia cambogia, Mucuna pruriens, Ocimum sanctum, Panax ginseng, Pueraria lobata, Salvia miltiorrhiza, Schisandra sinensis, Scutellaria baicalensis, Siraitia grosvenorii, Terminalia arjuna and Terminalia chebula), and some European herbs (Echinacea purpurea, Hypericum perforatum, Vitis vinifera).

Author(s): 
Filipiak-Szok, Anna
Kurzawa, Marzanna
Sz?yk, Edward
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

Tannins are polyphenolic compounds of complex structures formed by secondary metabolism in several plants. These polyphenolic compounds have different applications, such as drugs, anti-corrosion agents, flocculants, and tanning agents. This study analyses six different type of polyphenolic extracts by Fourier transform infrared spectroscopy (FTIR) combined with multivariate analysis.

Author(s): 
Grasel, Fábio dos Santos
Ferrão, Marco Flôres
Wolf, Carlos Rodolfo
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

BACKGROUND: Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span. METHODS: As part of phenotype development efforts for the Long Life Family Study, endophenotypes that represent exceptional survival were identified and heritability estimates were calculated. Principal components (PCs) analysis was carried out using 28 physiologic measurements from five trait domains (cardiovascular, cognition, physical function, pulmonary, and metabolic).

Author(s): 
Matteini, Amy M.
Fallin, M. Daniele
Kammerer, Candace M.
Schupf, Nicole
Yashin, Anatoli I.
Christensen, Kaare
Arbeev, Konstantin G.
Barr, Graham
Mayeux, Richard
Newman, Anne B.
Walston, Jeremy D.
Publication Title: 
Aging

Centenarians have been reported to share particular personality traits including low neuroticism and high extraversion and conscientiousness. Since these traits have moderate to high heritability and are associated with various health outcomes, personality appears linked to bio-genetic mechanisms which may contribute to exceptional longevity.

Author(s): 
Kato, Kaori
Zweig, Richard
Barzilai, Nir
Atzmon, Gil
Publication Title: 
Scientific Reports

Centenarians exhibit extreme longevity and a remarkable compression of morbidity. They have a unique capacity to maintain homeostatic mechanisms. Since small non-coding RNAs (including microRNAs) are implicated in the regulation of gene expression, we hypothesised that longevity of centenarians may reflect alterations in small non-coding RNA expression. We report the first comparison of microRNAs expression profiles in mononuclear cells from centenarians, octogenarians and young individuals resident near Valencia, Spain.

Author(s): 
Serna, Eva
Gambini, Juan
Borras, Consuelo
Abdelaziz, Kheira M.
Mohammed, Kheira
Belenguer, Angel
Sanchis, Paula
Avellana, Juan A.
Rodriguez-MaÒas, Leocadio
ViÒa, Jose
Publication Title: 
Cell Death and Differentiation

Human-nucleotide-excision repair (NER) deficiency leads to different developmental and segmental progeroid symptoms of which the pathogenesis is only partially understood. To understand the biological impact of accumulating spontaneous DNA damage, we studied the phenotypic consequences of DNA-repair deficiency in Caenorhabditis elegans. We find that DNA damage accumulation does not decrease the adult life span of post-mitotic tissue.

Author(s): 
Lans, H.
Lindvall, J. M.
Thijssen, K.
Karambelas, A. E.
Cupac, D.
FensgÂrd, O.
Jansen, G.
Hoeijmakers, J. H. J.
Nilsen, H.
Vermeulen, W.
Publication Title: 
The British Journal of Nutrition

Overall dietary patterns have been associated with health and longevity. We used principal component (PC) and cluster analyses to identify the prevailing dietary patterns of 99 744 participants, aged 60 years or older, living in nine European countries and participating in the European Prospective Investigation into Cancer and Nutrition (EPIC-Elderly cohort) and to examine their socio-demographic and lifestyle correlates.

Author(s): 
Bamia, Christina
Orfanos, Philippos
Ferrari, Pietro
Overvad, Kim
Hundborg, Heidi H.
Tj¯nneland, Anne
Olsen, Anja
Kesse, Emmanuelle
Boutron-Ruault, Marie-Christine
Clavel-Chapelon, FranÁoise
Nagel, Gabriele
Boffetta, Paolo
Boeing, Heiner
Hoffmann, Kurt
Trichopoulos, Dimitrios
Baibas, Nikos
Psaltopoulou, Theodora
Norat, Teresa
Slimani, Nadia
Palli, Domenico
Krogh, Vittorio
Panico, Salvatore
Tumino, Rosario
Sacerdote, Carlotta
Bueno-de-Mesquita, H. B.
Ocké, Marga C.
Peeters, Petra H.
van Rossum, Caroline T.
QuirÛs, JosÈ-RamÛn
S·nchez, MarÌa-JosÈ
Navarro, Carmen
Barricarte, Aurelio
Dorronsoro, Miren
Berglund, Gˆran
Wirf‰lt, Elisabet
Hallmans, Gˆran
Johansson, Ingegerd
Bingham, Sheila
Khaw, Kay-Tee
Spencer, Elizabeth A.
Roddam, Andrew W.
Riboli, Elio
Trichopoulou, Antonia
Publication Title: 
BMC genomics

BACKGROUND: While studying long-lived mutants has advanced our understanding of the processes involved in ageing, the mechanisms underlying natural variation in lifespan and ageing rate remain largely unknown. Here, we characterise genome-wide expression patterns of a long-lived, natural variant of Drosophila melanogaster resulting from selection for starvation resistance (SR) and compare it with normal-lived control flies (C).

Author(s): 
Doroszuk, Agnieszka
Jonker, Martijs J.
Pul, Nicolien
Breit, Timo M.
Zwaan, Bas J.
Publication Title: 
Aging Cell

Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by CR in humans. Here, we report that long-term CR in humans inhibits the IGF-1/insulin pathway in skeletal muscle, a key metabolic tissue. We also demonstrate that CR induces dramatic changes of the skeletal muscle transcriptional profile that resemble those of younger individuals.

Author(s): 
Mercken, Evi M.
Crosby, Seth D.
Lamming, Dudley W.
JeBailey, Lellean
Krzysik-Walker, Susan
Villareal, Dennis T.
Capri, Miriam
Franceschi, Claudio
Zhang, Yongqing
Becker, Kevin
Sabatini, David M.
de Cabo, Rafael
Fontana, Luigi
Publication Title: 
Journal of Human Genetics

Epidemiological studies have revealed that schizophrenia is highly heritable. However, genetic studies have not fully elucidated its etiology. Accumulating evidence suggests that epigenetic alterations may provide an additional explanation of its pathophysiology. We investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. Schizophrenia patients were confined to those at the stage of first-episode psychosis.

Author(s): 
Nishioka, Masaki
Bundo, Miki
Koike, Shinsuke
Takizawa, Ryu
Kakiuchi, Chihiro
Araki, Tsuyoshi
Kasai, Kiyoto
Iwamoto, Kazuya

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