Progestins

Publication Title: 
American Family Physician

The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years.

Author(s): 
Hill, D. Ashley
Crider, Mark
Hill, Susan R.
Publication Title: 
American Family Physician

The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years.

Author(s): 
Hill, D. Ashley
Crider, Mark
Hill, Susan R.
Publication Title: 
BMJ clinical evidence

INTRODUCTION: Dysmenorrhoea may begin soon after the menarche, after which it often improves with age, or it may originate later in life after the onset of an underlying causative condition. Dysmenorrhoea is common, and in up to 20% of women it may be severe enough to interfere with daily activities. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for primary dysmenorrhoea?

Author(s): 
Latthe, Pallavi Manish
Champaneria, Rita
Khan, Khalid Saeed
Publication Title: 
American Family Physician

The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years.

Author(s): 
Hill, D. Ashley
Crider, Mark
Hill, Susan R.
Publication Title: 
Obstetrics and Gynecology Clinics of North America

This article focuses on the cause, pathophysiology, differential diagnosis of, and treatment options for vasomotor symptoms. In addition, it summarizes important points for health care providers caring for perimenopausal and postmenopausal women with regard to health maintenance, osteoporosis, cardiovascular disease, and vaginal atrophy.

Author(s): 
Krause, Miriam S.
Nakajima, Steven T.
Publication Title: 
The Oncologist

Many therapies are being studied for the treatment of hot flashes for individuals with cancer, yet few studies have demonstrated safe and effective clinical benefit for those who suffer from this distressing symptom. The purpose of this paper is to assess the current options for the management of hot flashes, examining key endpoints from recent clinical trials and reviewing future directions. Hot flashes are a common stressful symptom for individuals with cancer, particularly women with a history of breast cancer and men with prostate cancer.

Author(s): 
Morrow, Phuong Khanh H.
Mattair, Danielle N.
Hortobagyi, Gabriel N.
Publication Title: 
Maturitas

OBJECTIVES: To investigate the biological activities of Justicia pectoralis Jacq. (Acanthaceae), an herbal medicine used in Costa Rica (CR) for the management of menopausal symptoms and dysmenorrhea. STUDY DESIGN: The aerial parts of J. pectoralis were collected, dried and extracted in methanol. To establish possible mechanisms of action of JP for the treatment of menopausal symptoms, the estrogenic and progesterone agonists, and antiinflammatory activities were investigated.

Author(s): 
Locklear, Tracie D.
Huang, Yue
Frasor, Jonna
Doyle, Brian J.
Perez, Alice
Gomez-Laurito, Jorge
Mahady, Gail B.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

In animal studies, testosterone decreases, whereas estrogen increases, cortisol production. In one clinical study, short-term testosterone replacement attenuated corticotrophin-releasing hormone-stimulated cortisol secretion during leuprolide-induced hypogonadism in young men. The effects of longer term testosterone treatment on spontaneous cortisol secretion in younger or older men are unknown.

Author(s): 
Muniyappa, Ranganath
Veldhuis, Johannes D.
Harman, S. Mitchell
Sorkin, John D.
Blackman, Marc R.
Publication Title: 
Steroids

Progesterone plays a central role in women's reproductive health. Synthetic progestins, such as medroxyprogesterone acetate (MPA) are often used in hormone replacement therapy (HRT), oral contraceptives, and for the treatment of endometriosis and infertility. Although MPA is clinically effective, it also promiscuously binds to androgen and glucocorticoid receptors (AR/GR) leading to many undesirable side effects including cardiovascular diseases and breast cancers. Therefore, identifying alternative progestins is clinically significant.

Author(s): 
Toh, M. F.
Sohn, J.
Chen, S. N.
Yao, P.
Bolton, J. L.
Burdette, J. E.
Publication Title: 
Planta Medica

Menopausal women suffer from a variety of symptoms, including hot flashes and night sweats, which can affect quality of life. Although it has been the treatment of choice for relieving these symptoms, hormone therapy has been associated with increased breast cancer risk leading many women to search for natural, efficacious, and safe alternatives such as botanical supplements.

Author(s): 
Hajirahimkhan, Atieh
Dietz, Birgit M.
Bolton, Judy L.

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