Propiophenones

Publication Title: 
Electroencephalography and Clinical Neurophysiology
Author(s): 
Klemm, W. R.
Publication Title: 
Planta Medica

The use of chromatographic assays to assess the residual complexity of materials that are purified from natural sources by chromatographic means is, in a sense, a case of the fox watching the henhouse. Beside their static residual complexity, which is intrinsic to their metabolic origin, biologically active natural materials can also be involved in chemical reactions that lead to dynamic residual complexity.

Author(s): 
Chen, Shao-Nong
Lankin, David C.
Chadwick, Lucas R.
Jaki, Birgit U.
Pauli, Guido F.
Publication Title: 
Molecular Nutrition & Food Research

Hop-derived products may contain xanthohumol (XN), isoxanthohumol (IX), and the potent phytoestrogen 8-prenylnaringenin (8-PN). To evaluate the potential health effects of these prenylflavonoids on breast tissue, their concentration, nature of metabolites, and biodistribution were assessed and compared with 17beta-estradiol (E(2)) exposure. In this dietary intervention study, women were randomly allocated to hop (n=11; 2.04 mg XN, 1.20 mg IX, and 0.1 mg 8-PN per supplement) or control (n=10).

Author(s): 
Bolca, Selin
Li, Jinghu
Nikolic, Dejan
Roche, Nathalie
Blondeel, Phillip
Possemiers, Sam
De Keukeleire, Denis
Bracke, Marc
Heyerick, Arne
van Breemen, Richard B.
Depypere, Herman
Publication Title: 
Analytical Chemistry

Inhibitors of quinone reductase-2 (NQO2; QR-2) can have antimalarial activity and antitumor activities or can function as chemoprevention agents by preventing the metabolic activation of toxic quinones such as menadione. To expedite the search for new natural product inhibitors of QR-2, we developed a screening assay based on ultrafiltration liquid chromatography-mass spectrometry that is compatible with complex samples such as bacterial or botanical extracts.

Author(s): 
Choi, Yongsoo
Jermihov, Katherine
Nam, Sang-Jip
Sturdy, Megan
Maloney, Katherine
Qiu, Xi
Chadwick, Lucas R.
Main, Matthew
Chen, Shao-Nong
Mesecar, Andrew D.
Farnsworth, Norman R.
Pauli, Guido F.
Fenical, William
Pezzuto, John M.
van Breemen, Richard B.
van Breemen, Richard R.
Publication Title: 
Molecular Nutrition & Food Research

SCOPE: Xanthohumol (XN), a dietary flavonoid found in hops, may have health-protective actions against cardiovascular disease and type 2 diabetes. Yet, there are limited data on the pharmacokinetics (PK) of XN. This study provides PK parameters for XN and its major metabolites in rats. METHODS AND RESULTS: A PK study was conducted in male jugular vein-cannulated Sprague-Dawley rats. Rats (n = 12/group) received an intravenous (IV) injection (1.86 mg/kg BW) or an oral gavage of a low (1.86 mg/kg BW), medium (5.64 mg/kg BW), or high (16.9 mg/kg BW) dose of XN.

Author(s): 
Legette, LeeCole
Ma, Lian
Reed, Ralph L.
Miranda, Cristobal L.
Christensen, John Mark
Rodriguez-Proteau, Rosita
Stevens, Jan F.
Publication Title: 
Molecular Nutrition & Food Research

SCOPE: Hops contain the phytoestrogen, 8-prenylnaringenin, and the cytoprotective compound, xanthohumol (XH). XH induces the detoxification enzyme, NAD(P)H-quinone oxidoreductase (NQO1) in vitro; however, the tissue distribution of XH and 8-prenylnaringenin and their tissue-specific activity have not been analyzed. METHODS AND RESULTS: An orally administered hop extract and subcutaneously injected XH were administered to Sprague-Dawley rats over 4 days. LC-MS-MS analysis of plasma, liver, and mammary gland revealed that XH accumulated in liver and mammary glands.

Author(s): 
Dietz, Birgit M.
Hagos, Ghenet K.
Eskra, Jillian N.
Wijewickrama, Gihani T.
Anderson, Jeffrey R.
Nikolic, Dejan
Guo, Jian
Wright, Brian
Chen, Shao-Nong
Pauli, Guido F.
van Breemen, Richard B.
Bolton, Judy L.
Publication Title: 
Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (editor-in-Chief) ... [et Al.]

At its most ambitious, untargeted metabolomics aims to characterize and quantify all of the metabolites in a given system. Metabolites are often present at a broad range of concentrations and possess diverse physical properties complicating this task. Performing multiple sample extractions, concentrating sample extracts, and using several separation and detection methods are common strategies to overcome these challenges but require a great amount of resources.

Author(s): 
Kirkwood, Jay S.
Maier, Claudia
Stevens, Jan F.
Publication Title: 
The Journal of Biological Chemistry

Mild, mitochondrial uncoupling increases energy expenditure and can reduce the generation of reactive oxygen species (ROS). Activation of cellular, adaptive stress response pathways can result in an enhanced capacity to reduce oxidative damage. Together, these strategies target energy imbalance and oxidative stress, both underlying factors of obesity and related conditions such as type 2 diabetes. Here we describe a metabolomics-driven effort to uncover the anti-obesity mechanism(s) of xanthohumol (XN), a prenylated flavonoid from hops.

Author(s): 
Kirkwood, Jay S.
Legette, LeeCole L.
Miranda, Cristobal L.
Jiang, Yuan
Stevens, Jan F.
Publication Title: 
Molecular Nutrition & Food Research

Hop-derived products may contain xanthohumol (XN), isoxanthohumol (IX), and the potent phytoestrogen 8-prenylnaringenin (8-PN). To evaluate the potential health effects of these prenylflavonoids on breast tissue, their concentration, nature of metabolites, and biodistribution were assessed and compared with 17beta-estradiol (E(2)) exposure. In this dietary intervention study, women were randomly allocated to hop (n=11; 2.04 mg XN, 1.20 mg IX, and 0.1 mg 8-PN per supplement) or control (n=10).

Author(s): 
Bolca, Selin
Li, Jinghu
Nikolic, Dejan
Roche, Nathalie
Blondeel, Phillip
Possemiers, Sam
De Keukeleire, Denis
Bracke, Marc
Heyerick, Arne
van Breemen, Richard B.
Depypere, Herman
Publication Title: 
Molecular Nutrition & Food Research

Hop-derived products may contain xanthohumol (XN), isoxanthohumol (IX), and the potent phytoestrogen 8-prenylnaringenin (8-PN). To evaluate the potential health effects of these prenylflavonoids on breast tissue, their concentration, nature of metabolites, and biodistribution were assessed and compared with 17beta-estradiol (E(2)) exposure. In this dietary intervention study, women were randomly allocated to hop (n=11; 2.04 mg XN, 1.20 mg IX, and 0.1 mg 8-PN per supplement) or control (n=10).

Author(s): 
Bolca, Selin
Li, Jinghu
Nikolic, Dejan
Roche, Nathalie
Blondeel, Phillip
Possemiers, Sam
De Keukeleire, Denis
Bracke, Marc
Heyerick, Arne
van Breemen, Richard B.
Depypere, Herman
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