Propranolol

Publication Title: 
Indian Journal of Physiology and Pharmacology

In rats, propranolol potentiated alcohol and pentobarbitone hypnosis, but not barbital sleeping time, indicating enzyme inhibition as a possible mechanism of potentiation. Propranolol showed anticonvulsant effect on normal and reserpine treated rats by MES test, but showed dose related lowering of MET. Probable mechanisms are discussed.

Author(s): 
Iyer, K. S.
Govindankutty, A.
Radha, M.
Publication Title: 
PLoS medicine

BACKGROUND: Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are urgently needed to reduce global morbidity and mortality. Our prior results suggested that inhibiting erythrocyte Gs signaling blocked invasion by the human malaria parasite Plasmodium falciparum. METHODS AND FINDINGS: We investigated the erythrocyte guanine nucleotide regulatory protein Gs as a novel antimalarial target.

Author(s): 
Murphy, Sean C.
Harrison, Travis
Hamm, Heidi E.
Lomasney, Jon W.
Mohandas, Narla
Haldar, Kasturi
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The bark of Terminalia arjuna L. (Combretaceae) is used in Ayurveda since ancient times for the treatment of cardiac disorders. Previous laboratory investigations have demonstrated the use of the bark in cardiovascular complications. The present study was aimed to find the effect of 70% alcoholic extract of Terminalia arjuna on anaesthetized dog blood pressure and probable site of action.

Author(s): 
Nammi, Srinivas
Gudavalli, Rambabu
Babu, Behara S. Ravindra
Lodagala, Durga S.
Boini, Krishna M.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The bark of Terminalia arjuna L. (Combretaceae) is used in Ayurveda since ancient times for the treatment of cardiac disorders. Previous laboratory investigations have demonstrated the use of the bark in cardiovascular complications. The present study was aimed to find the effect of 70% alcoholic extract of Terminalia arjuna on anaesthetized dog blood pressure and probable site of action.

Author(s): 
Nammi, Srinivas
Gudavalli, Rambabu
Babu, Behara S. Ravindra
Lodagala, Durga S.
Boini, Krishna M.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

This study examined the effect of schisandrin, one of the major lignans isolated from Schisandra chinensis, on spontaneous contraction in rat colon and its possible mechanisms. Schisandrin produced a concentration-dependent inhibition (EC₅₀=1.66 μM) on the colonic spontaneous contraction.

Author(s): 
Yang, Jiaming
Ip, Paul S. P.
Yeung, John H. K.
Che, Chun-Tao
Publication Title: 
Pancreas

OBJECTIVES: Tobacco-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) activates β-adrenergic receptor (β-AR) signaling through Src/focal adhesion kinases (FAKs)/mitogen-activated protein kinase to modulate proliferation, migration, and survival. Apigenin (4', 5, 7-trihydroxyflavone) is reported to attenuate proliferation and migration of cancer cells. This study was designed to determine the effects of apigenin on NNK-induced procarcinogenesis using human pancreatic cancer cells BxPC-3 and MIA PaCa-2, which express β-AR.

Author(s): 
Pham, Hung
Chen, Monica
Takahashi, Hiroki
King, Jonathan
Reber, Howard A.
Hines, Oscar Joe
Pandol, Stephen
Eibl, Guido
Publication Title: 
American Heart Journal

We prospectively evaluated 19 patients with prolonged chest pain not evolving to myocardial infarction and accompanied with reversible ST-T changes and tachycardia (heart rate greater than 100 beats/min) in order to correlate heart rate reduction with ischemic electrocardiographic (ECG) changes. Fourteen patients (74%) received previous long-term combined treatment with nifedipine and nitrates. Continuous ECG monitoring was carried out until heart rate reduction and at least one of the following occurred: (1) relief of pain or (2) resolution of ischemic ECG changes.

Author(s): 
Sclarovsky, S.
Bassevich, R.
Strasberg, null
Klainman, E.
Rechavia, E.
Sagie, A.
Agmon, J.
Publication Title: 
The Journal of Headache and Pain

Migraine occurs in about 15% of the general population. Migraine is usually managed by medication, but some patients do not tolerate migraine medication due to side effects or prefer to avoid medication for other reasons. Non-pharmacological management is an alternative treatment option. We systematically reviewed randomized clinical trials (RCTs) on manual therapies for migraine. The RCTs suggest that massage therapy, physiotherapy, relaxation and chiropractic spinal manipulative therapy might be equally effective as propranolol and topiramate in the prophylactic management of migraine.

Author(s): 
Chaibi, Aleksander
Tuchin, Peter J.
Russell, Michael Bjørn
Publication Title: 
The Journal of Headache and Pain

Migraine occurs in about 15% of the general population. Migraine is usually managed by medication, but some patients do not tolerate migraine medication due to side effects or prefer to avoid medication for other reasons. Non-pharmacological management is an alternative treatment option. We systematically reviewed randomized clinical trials (RCTs) on manual therapies for migraine. The RCTs suggest that massage therapy, physiotherapy, relaxation and chiropractic spinal manipulative therapy might be equally effective as propranolol and topiramate in the prophylactic management of migraine.

Author(s): 
Chaibi, Aleksander
Tuchin, Peter J.
Russell, Michael Bjørn
Publication Title: 
Journal of Veterinary Science

The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V for 20 min) was applied to bilateral Hoku (LI-4) and Zusanli (ST-36) on 12 hrs and 36 hrs after induction of colitis. EA-treatment significantly reduced the macroscopic damage and the myeloperoxidase activity of colonic samples at 3 days post-induction of colitis. Colitic colon showed a decreased in vitro motility.

Author(s): 
Kang, Jeoung Woo
Kim, Tae Wan
La, Jun Ho
Sung, Tae Sik
Kim, Hyun Ju
Kwon, Young Bae
Kim, Jeum Yong
Yang, Il Suk

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