Proton Pump Inhibitors

Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

BACKGROUND: Homeopathy is based on the principle of similitude (similia similibus curentur) using medicines that cause effects similar to the symptoms of disease in order to stimulate the reaction of the organism. Such vital, homeostatic or paradoxical reaction of the organism is closely related to rebound effect of drugs. METHOD: Review of the literature concerning the rebound effects of drugs used to suppress gastric acidity, particularly proton pump inhibitors (PPIs). RESULTS: The mechanism of action of these effects is discussed.

Author(s): 
Teixeira, Marcus Zulian
Publication Title: 
Alimentary Pharmacology & Therapeutics

Gastrointestinal dysmotility in systemic sclerosis (scleroderma) is prevalent in 90% of patients, increasing morbidity and in some cases mortality. The resultant gastrointestinal complications are usually extensive, involving many regions of the gut from the oesophagus to the anus. Collagen replacement of vascular and enteric smooth muscle results in hypomotility, lumen dilatation, tensile rigidity and eventual loss of organ functions. The aim of this paper is to provide an overview of systemic sclerosis-related gastrointestinal dysmotility and available/potential therapeutic options.

Author(s): 
Sallam, H.
McNearney, T. A.
Chen, J. D. Z.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of chebulinic acid was observed against CRU (62.9%), AS (55.3%), AL (80.67%) and PL (66.63%) induced ulcer models.

Author(s): 
Mishra, Vaibhav
Agrawal, Manali
Onasanwo, Samuel Adetunji
Madhur, Gaurav
Rastogi, Preeti
Pandey, Haushila Prasad
Palit, Gautam
Narender, Tadigoppula
Publication Title: 
Methods and Findings in Experimental and Clinical Pharmacology

The general pharmacological profiles of a novel proton pump inhibitor, (+/-)-5-methoxy-2-[[(4-methoxy-3,5-dimethylpyrid-2-yl)methyl]sulfi nyl]- 1H-imidazo[4,5-b]pyridine, TU-199) on the central nervous system, cardiorespiratory system, autonomic nervous system, gastrointestinal system and renal functions were investigated. TU-199 had no effects on general signs and behavior in mice. TU-199 (300 mg/kg p.o.) decreased locomotor activity 3 h after administration in mice.

Author(s): 
Kakinoki, B.
Ono, C.
Yamazaki, N.
Chikamatsu, N.
Wakatsuki, D.
Uchiyama, K.
Morinaka, Y.
Publication Title: 
Arzneimittel-Forschung

The general pharmacological properties of YJA 20379-1 (2-amino-4,5-dihydro-8-phenylimidazo[2,1-b]thiazolo[4,5-g]benzo thi azole), a novel proton pump inhibitor with antiulcer activities, were investigated in mice, rats, guinea pig and rabbits. YJA 20379-1 at oral doses of 50, 100 and 200 mg/kg did not affect the general behaviour, hexobarbital hypnosis, motor coordination and body temperature in mice. The drug does not have analgesic and anticonvulsant action at 200 mg/kg p.o. The locomotor activity was not affected at 100 mg/kg p.o., but at 200 mg/kg, the activity was suppressed.

Author(s): 
Lee, E. B.
Cho, S. I.
Cheon, S. A.
Chang, M. S.
Kim, K. B.
Sohn, S. K.
Chung, Y. K.
Publication Title: 
Arzneimittel-Forschung

The general pharmacological properties of YJA20379-8 (3-butyryl-4-[(R)-1-methylbenzylamino]-8-ethoxy-1,7-naphthyridine, CAS 187654-40-6), a new H+/K(+)-ATPase inhibitor with anti-ulcer activities, were investigated in mice, rats and guinea pigs. YJA20379-8 at oral doses of 25, 50 and 100 mg/kg did not affect the locomotor activity, hexobarbital hypnosis and motor coordination in mice. The drug did not have analgesic action and anticonvulsant action at the doses of 100 mg/kg p.o. The respiration and blood pressure were not affected at 10 mg/kg i.v. in rats.

Author(s): 
Lee, E. B.
Cho, S. I.
Chang, H. O.
Chang, M. S.
Kim, K. B.
Lee, S. B.
Choi, W. S.
Publication Title: 
Gut

BACKGROUND: Non-cardiac chest pain (NCCP) is an extremely debilitating condition of uncertain origin which is difficult to treat and consequently has a high psychological morbidity. Hypnotherapy has been shown to be effective in related conditions such as irritable bowel syndrome where its beneficial effects are long lasting. AIMS: This study aimed to assess the efficacy of hypnotherapy in a selected group of patients with angina-like chest pain in whom coronary angiography was normal and oesophageal reflux was not contributory.

Author(s): 
Jones, H.
Cooper, P.
Miller, V.
Brooks, N.
Whorwell, P. J.
Publication Title: 
Current Gastroenterology Reports

Functional dyspepsia (FD) is common in children, with as many as 80% of those being evaluated for chronic abdominal pain reporting symptoms of epigastric discomfort, nausea, or fullness. It is known that patients with persistent complaints have increased comorbidities such as depression and anxiety. The interaction with psychopathologic variables has been found to mediate the association between upper abdominal pain and gastric hypersensitivity. These observations suggest that abnormal central nervous system processing of gastric stimuli may be a relevant pathophysiologic mechanism in FD.

Author(s): 
Perez, Maria E.
Youssef, Nader N.
Publication Title: 
Expert Opinion on Pharmacotherapy

IMPORTANCE OF THE FIELD: Dyspeptic symptoms are highly prevalent in the population and represent a major burden for healthcare systems. The ROME III criteria address and define two separate entities of functional dyspepsia: epigastric pain syndrome and postprandial distress syndrome. The etiology of dyspeptic symptoms is heterogeneous, underlying mechanisms are poorly understood and symptomatic improvement after drug therapy is often incomplete.

Author(s): 
Kandulski, Arne
Venerito, Marino
Malfertheiner, Peter
Publication Title: 
Alimentary Pharmacology & Therapeutics

BACKGROUND: Treatment of noncardiac chest pain (NCCP) remains a challenge. This is in part due to the heterogeneous nature of this disorder. Several conditions are associated with NCCP including gastro-oesophageal reflux disease (GERD), oesophageal dysmotility, oesophageal hypersensitivity as well as others. AIM: To determine the currently available therapeutic modalities for NCCP. METHODS: We performed a systematic review of the literature that was published between January, 1980 and March, 2011. We identified 734 studies; 68 of them met entry criteria.

Author(s): 
Hershcovici, T.
Achem, S. R.
Jha, L. K.
Fass, R.

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