Punicaceae

Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

Drug discovery from complex mixture like Chinese herbs is a challenge and extensive false positives make the obtainment of specific bioactive compounds difficult. In the present study, a novel sample preparation method was proposed to rapidly reveal the specific bioactive compounds from complex mixtures using ?-glucosidase as a case. Firstly, aqueous and methanol extracts of 500 traditional Chinese medicines were carried out with the aim of finding new sources of ?-glucosidase inhibitors.

Author(s): 
Li, D. Q.
Zhao, J.
Xie, J.
Li, S. P.
Publication Title: 
Biological & Pharmaceutical Bulletin

Avian pathogenic Escherichia coli (APEC) causes inflammation in multiple organs of chickens called avian colibacillosis, and results in serious economic loss to the chicken industry. Polyphenolic compounds possess a wide range of physiological activities that may contribute to their beneficial effects against inflammation-related diseases. In this study, the curative effect and mechanism of action of the polyphenolic extracts from Punica granatum L. and Terminalia chebula Retz. in chickens challenged with APEC were studied.

Author(s): 
Zhong, Xinlu
Shi, Yaran
Chen, Jiajia
Xu, Jianqing
Wang, Lei
Beier, Ross C.
Hou, Xiaolin
Liu, Fenghua
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

Type 2 diabetes has become a global epidemic. Modern medicines, despite offering a variety of effective treatment options, can have several adverse effects. Ayurveda, a science that uses herbal medicines extensively, originated in India. Of considerable interest is the adoption of Ayurveda by the mainstream medical system in some European countries (e.g., Hungary), emphasizing this modality is increasing worldwide recognition. From ancient times, some of these herbal preparations have been used in the treatment of diabetes.

Author(s): 
Saxena, Abha
Vikram, Naval Kishore
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

Type 2 diabetes has become a global epidemic. Modern medicines, despite offering a variety of effective treatment options, can have several adverse effects. Ayurveda, a science that uses herbal medicines extensively, originated in India. Of considerable interest is the adoption of Ayurveda by the mainstream medical system in some European countries (e.g., Hungary), emphasizing this modality is increasing worldwide recognition. From ancient times, some of these herbal preparations have been used in the treatment of diabetes.

Author(s): 
Saxena, Abha
Vikram, Naval Kishore
Publication Title: 
Diabetes, Obesity & Metabolism

PPARs are transcription factors belonging to the superfamily of nuclear receptors. PPAR-alpha is involved in the regulation of fatty acid (FA) uptake and oxidation, inflammation and vascular function, while PPAR-gamma participates in FA uptake and storage, glucose homeostasis and inflammation. The PPARs are thus major regulators of lipid and glucose metabolism. Synthetic PPAR-alpha or PPAR-gamma agonists have been widely used in the treatment of dyslipidaemia, hyperglycaemia and their complications. However, they are associated with an incidence of adverse events.

Author(s): 
Li, Yuhao
Qi, Yanfei
Huang, Tom H. W.
Yamahara, Johji
Roufogalis, Basil D.
Publication Title: 
The Journal of Nutrition

Interleukin (IL)-1beta induces the expression of matrix metalloproteinases (MMPs) implicated in cartilage resorption and joint degradation in osteoarthritis (OA). Pomegranate fruit extract (PFE) was recently shown to exert anti-inflammatory effects in different disease models. However, no studies have been undertaken to investigate whether PFE constituents protect articular cartilage. In the present studies, OA chondrocytes or cartilage explants were pretreated with PFE and then stimulated with IL-1beta at different time points in vitro.

Author(s): 
Ahmed, Salahuddin
Wang, Naizhen
Hafeez, Bilal Bin
Cheruvu, Vinay K.
Haqqi, Tariq M.
Publication Title: 
The Journal of Nutrition

Ellagitannins (ETs) from pomegranate juice (PJ) are reported to have numerous biological properties, but their absorption and metabolism in humans are poorly understood. To investigate the pharmacokinetics of pomegranate ETs, 18 healthy volunteers were given 180 mL of PJ concentrate, and blood samples were obtained for 6 h afterwards. Twenty-four-hour urine collections were obtained on the day before (-1), the day of (0), and the day after (+1) the study.

Author(s): 
Seeram, Navindra P.
Henning, Susanne M.
Zhang, Yanjun
Suchard, Marc
Li, Zhaoping
Heber, David
Publication Title: 
Nutrition (Burbank, Los Angeles County, Calif.)

OBJECTIVE: Although consumption of dietary supplements containing pomegranate extract (POMx) by patients with arthritis is on the rise, the efficacy of such preparations in suppressing joint inflammation and damage is not known. The present study was designed to evaluate a standardized preparation of POMx using collagen-induced arthritis (CIA) in mice, a widely used animal model of rheumatoid arthritis. METHODS: CIA-susceptible DBA/1 mice were fed POMx by gavage before and after immunization with chicken type II collagen.

Author(s): 
Shukla, Meenakshi
Gupta, Kalpana
Rasheed, Zafar
Khan, Khursheed A.
Haqqi, Tariq M.
Publication Title: 
Journal of Medicinal Food

Pomegranate juice (PJ), a rich source of polyphenols including ellagitannins, has attracted much attention due to its reported health benefits. This has resulted in the consumption of liquid and powder pomegranate extracts as alternatives to PJ. Therefore establishing the bioavailability of polyphenols from these extract preparations is necessary.

Author(s): 
Seeram, Navindra P.
Zhang, Yanjun
McKeever, Rodney
Henning, Susanne M.
Lee, Ru-po
Suchard, Marc A.
Li, Zhaoping
Chen, Steve
Thames, Gail
Zerlin, Alona
Nguyen, Martha
Wang, David
Dreher, Mark
Heber, David
Publication Title: 
Experimental Dermatology

Solar ultraviolet (UV) radiation, particularly its UVB (290-320 nm) component, is the primary cause of many adverse biological effects including photoageing and skin cancer. UVB radiation causes DNA damage, protein oxidation and induces matrix metalloproteinases (MMPs). Photochemoprevention via the use of botanical antioxidants in affording protection to human skin against UVB damage is receiving increasing attention. Pomegranate, from the tree Punica granatum, contains anthocyanins and hydrolysable tannins and possesses strong antioxidant and anti-tumor-promoting properties.

Author(s): 
Afaq, Farrukh
Zaid, Mohammad Abu
Khan, Naghma
Dreher, Mark
Mukhtar, Hasan

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