Quetiapine Fumarate

Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

Epigenetic regulation may be involved in the pathophysiology of mental disorders, such as schizophrenia and bipolar disorder, and in the pharmacological action of drugs. Characterizing the epigenetic effects of drugs is an important step to optimal treatment. We performed comprehensive and gene-specific DNA methylation analyses of quetiapine using human neuroblastoma cells. Human neuroblastoma cells were cultured with quetiapine for 8 days, and DNA methylation analysis was performed using Infinium HumanMethylation27 BeadChip. A total of 1173 genes showed altered DNA methylation.

Author(s): 
Sugawara, Hiroko
Bundo, Miki
Asai, Tatsuro
Sunaga, Fumiko
Ueda, Junko
Ishigooka, Jun
Kasai, Kiyoto
Kato, Tadafumi
Iwamoto, Kazuya
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