Publication Title: 
Growth hormone & IGF research: official journal of the Growth Hormone Research Society and the International IGF Research Society

OBJECTIVE: Since a reduction of the insulin/IGF-1 signaling cascade extends life span in many species and IGF-1 signaling might partly mediate the effects of caloric restriction (CR), an experimental intervention for increasing longevity, the purpose of the present study was to use quantitative trait loci (QTL) analysis, an unbiased genetic approach, to identify particular regions of the genome influencing plasma IGF-1 levels in an F2 intercross between F344 and LOU/C rats; the latter being an inbred strain of Wistar origin, considered as a model of healthy aging since it resists to age (an

Marissal-Arvy, Nathalie
Duron, Emmanuelle
Parmentier, Frédéric
Zizzari, Philippe
MormËde, Pierre
Epelbaum, Jacques
Publication Title: 
Obesity Research

OBJECTIVE: A previous study in our laboratory (Moyer et al., Obes Res. 1994;2:255-62 found that, in response to uncontrollable laboratory stress, women with a high waist-to-hip ratio (WHR) had higher cortisol reactivity, poorer coping skills, and lower anger responses than women with low WHR. We aimed to compare high WHR men's stress responses to these women. RESEARCH METHODS AND PROCEDURES: The current study examined cortisol reactivity and psychological data of 27 healthy high WHR men exposed to the same laboratory challenges as the women from our previous study.

Epel, E. E.
Moyer, A. E.
Martin, C. D.
Macary, S.
Cummings, N.
Rodin, J.
Rebuffe-Scrive, M.
Publication Title: 
Scandinavian Journal of Immunology

In a number of studies it has been shown that psychological factors in general and specifically emotional factors can be correlated to changes in immunological function and defence mechanisms. Although the mediating pathways between the central nervous system and the immune system still remain unclear, it is known that some of the 'classical stress hormones' such as cortisol and catecholamines have modulatory effects on different immunological parameters.

Zachariae, R.
Bjerring, P.
Zachariae, C.
Arendt-Nielsen, L.
Nielsen, T.
Eldrup, E.
Larsen, C. S.
Gotliebsen, K.
Publication Title: 
European Journal of Applied Physiology and Occupational Physiology

Little information is available concerning the influence of subconscious mechanisms on neuroendocrine function, more specifically, proenkephalin peptide F release. Ten men [5 middle distance runners (21.6 (SD 0.54 years) and 5 untrained men (24.0 (SD 4.3 years)] consented to be volunteers in this investigation. Submaximal exercise intensities of 25% and 50% of peak oxygen consumption (VO2) (8 min stages) were used for both the control and hypnosis treatments.

Kraemer, W. J.
Lewis, R. V.
Triplett, N. T.
Koziris, L. P.
Heyman, S.
Noble, B. J.
Publication Title: 

In the rat brain, gamma-hydroxybutyric-acid (GHB) increases the concentrations of 3alpha-hydroxy,5alpha-pregnan-20-one (allopregnanolone, 3alpha,5alpha-THP) and 3alpha,21-dihydroxy,5alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone/3alpha,5alphaTHDOC), two neurosteroids acting as positive allosteric modulators of gamma-aminobutyric acid (GABA)(A) receptors. This study was aimed at assessing whether neurosteroids play a role in GHB-induced loss of righting reflex (LORR).

Barbaccia, Maria Luisa
Carai, Mauro A. M.
Colombo, Giancarlo
Lobina, Carla
Purdy, Robert H.
Gessa, Gian Luigi
Publication Title: 
Physiology & Behavior

The aim of this work was to study the influence of the hormonal milieu on the facilitory effects of olfactory stimuli originating from female urine on lordosis behavior in orchidectomized (ORCH) feminized rats. Urine from ovariectomized (OVX) rats was shown to increase the proportion of ORCH rats displaying lordosis behavior, an effect which was enhanced if the OVX rats had been given progesterone. Treatment of OVX rats with estradiol benzoate did not affect the pheromonal activity of their urine.

Schaeffer, C.
Aron, C.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

In animal studies, testosterone decreases, whereas estrogen increases, cortisol production. In one clinical study, short-term testosterone replacement attenuated corticotrophin-releasing hormone-stimulated cortisol secretion during leuprolide-induced hypogonadism in young men. The effects of longer term testosterone treatment on spontaneous cortisol secretion in younger or older men are unknown.

Muniyappa, Ranganath
Veldhuis, Johannes D.
Harman, S. Mitchell
Sorkin, John D.
Blackman, Marc R.
Publication Title: 
Biology of Reproduction

Short day lengths or reduced food availability are salient cues for small mammals that breed seasonally. Photoperiod-mediated gonadal regression in white-footed mice (Peromyscus leucopus) is a slow, orderly process that involves testicular apoptosis. Testicular regression in response to restricted caloric intake is relatively rapid, and it is generally reversed quickly by ad libitum (ad lib) feeding.

Young, K. A.
Zirkin, B. R.
Nelson, R. J.
Publication Title: 

This study examines the possibility of a humorally mediated analgesic response to spinal manipulative therapy by determination of plasma levels of beta-endorphin, adrenocorticotropic hormone (ACTH), and cortisol before and after intervention. Forty male subjects (20 symptomatic, 20 asymptomatic) were allocated into four equal groups. Two treatment groups were given spinal manipulative therapy, and two groups underwent a sham procedure.

Christian, G. F.
Stanton, G. J.
Sissons, D.
How, H. Y.
Jamison, J.
Alder, B.
Fullerton, M.
Funder, J. W.
Publication Title: 
Hepatobiliary & pancreatic diseases international: HBPD INT

BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPAR-gamma) and nuclear factor kappa B (NF-kappaB) play important roles in liver fibrosis. This study aimed to investigate the effects of Dan-shao-hua-xian, a preparation of traditional Chinese medicine, on the expression of PPAR-gamma and NF-kappaB in the fibrotic livers of rats.

Wang, He-Yan
Cheng, Ming-Liang


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