Radiopharmaceuticals

Publication Title: 
The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry

OBJECTIVE: The objective of this study was to determine the effects of a 14-day healthy longevity lifestyle program on cognition and cerebral metabolism in people with mild age-related memory complaints.

Author(s): 
Small, Gary W.
Silverman, Daniel H. S.
Siddarth, Prabha
Ercoli, Linda M.
Miller, Karen J.
Lavretsky, Helen
Wright, Benjamin C.
Bookheimer, Susan Y.
Barrio, Jorge R.
Phelps, Michael E.
Publication Title: 
Parkinsonism & Related Disorders

The stable 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian (HP) rhesus monkey model of Parkinson's disease (PD) has been frequently used to test preclinical experimental therapeutics targeted to treat patients with advanced PD who suffer from motor fluctuations and drug-induced dyskinesias. We retrospectively analyzed data from 17 stable HP rhesus monkeys treated long-term with chronic intermittent dosing of levodopa (LD) in an attempt to induce choreoathetoid and dystonic dyskinesias.

Author(s): 
Lieu, Christopher A.
Deogaonkar, Milind
Bakay, Roy A. E.
Subramanian, Thyagarajan
Publication Title: 
NeuroImage

Time of arrival (TOA) of a bolus of contrast agent to the tissue voxel is a reference time point critical for the Early Time Points Perfusion Imaging Method (ET) to make relative cerebral blood flow (rCBF) maps. Due to the low contrast to noise (CNR) condition at TOA, other useful reference time points known as relative time of arrival data points (rTOA) are investigated. Candidate rTOA's include the time to reach the maximum derivative, the maximum second derivative, and the maximum fractional derivative.

Author(s): 
Kwong, Kenneth K.
Wu, Ona
Chan, Suk-Tak
Nelissen, Koen
Kholodov, Mykhaylo
Chesler, David A.
Publication Title: 
The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry

OBJECTIVES: To determine whether psychological well-being in people with mild cognitive impairment (MCI), a risk state for Alzheimer disease (AD), is associated with in vivo measures of brain pathology. METHODS: Cross-sectional clinical assessments and positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[F18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), a molecule that binds to plaques and tangles, were performed on middle-aged and older adults at a university research institute.

Author(s): 
Chen, Stephen T.
Siddarth, Prabha
Saito, Nathan Y.
Rueda, Flori
Haight, Taylor
Ercoli, Linda M.
Miller, Karen J.
Lavretsky, Helen
Barrio, Jorge R.
Bookheimer, Susan Y.
Small, Gary W.
Merrill, David A.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: The aim of this 2-study research project was to measure the physiologic effect of the M technique (see Appendix for description) on the brain using single photon emission computed tomography (SPECT) and compare it to conventional massage therapy. METHODS: In the first study, 4 participants received 1 M technique session. Each participant was injected through the intravenous cannula (IV) with 7 mCi (99m)Tc and scanned using SPECT before the M technique session, and then was injected with 25 mCi (99m)Tc through the IV and scanned using SPECT after the M technique session.

Author(s): 
Buckle, Jane
Newberg, Andrew
Wintering, Nancy
Hutton, Ellyn
Lido, Catherine
Farrar, John T.
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: Experienced practitioners of yoga have been shown to alter brain function, but this case series measured cerebral blood flow before and after a 12-week training program in Iyengar yoga (IY) for naïve subjects. METHODS: On the first day, each of the 4 subjects listened to the teacher speaking on the history and background of the yoga program while they were injected with 250 MBq of (99m)Tc-bicisate and received a single photon emission computed tomography scan (pre-program baseline).

Author(s): 
Cohen, Debbie L.
Wintering, Nancy
Tolles, Victoria
Townsend, Raymond R.
Farrar, John T.
Galantino, Mary Lou
Newberg, Andrew B.
Publication Title: 
Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

The purpose of this study was to propose and validate a method for the noninvasive measurement of cerebral metabolic rate of glucose (CMRGlc) by fluorodeoxyglucose (FDG) PET with a standardized input function (SIF) and an autoradiographic method. METHODS: Plasma input functions, measured by intermittent arterial blood samplings after the intravenous injection of FDG, in 44 patients who had fasted for at least 6 h, were used to generate the SIF.

Author(s): 
Tsuchida, T.
Sadato, N.
Yonekura, Y.
Nakamura, S.
Takahashi, N.
Sugimoto, K.
Waki, A.
Yamamoto, K.
Hayashi, N.
Ishii, Y.
Publication Title: 
Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine

The aims of this study were to determine whether body weight or body surface area (BSA) should be used for noninvasive measurement of the cerebral metabolic rate of glucose (CMRGlc) by FDG PET with a standardized input function (SIF) and an autoradiographic method and to validate the procedure in a large population from different PET centers. METHODS: Plasma input functions measured by intermittent arterial blood sampling after intravenous injection of FDG, in 101 patients from 1 institution who were fasting for at least 4 h, were used to generate the SIF.

Author(s): 
Shiozaki, T.
Sadato, N.
Senda, M.
Ishii, K.
Tsuchida, T.
Yonekura, Y.
Fukuda, H.
Konishi, J.
Publication Title: 
International Journal of Obesity (2005)

OBJECTIVE: Food intake is regulated by factors that modulate caloric requirements as well as food's reinforcing properties. In this study, we measured brain glucose utilization to an olfactory stimulus (bacon scent), and we examined the role of food restriction and genetic predisposition to obesity on such brain metabolic activity. METHODS: Zucker obese (Ob) and lean (Le) rats were divided into four groups: (1) Ob ad-libitum fed, (2) Ob food restricted (70% of ad libitum), (3) Le ad-libitum fed and (4) Le food restricted.

Author(s): 
Thanos, P. K.
Michaelides, M.
Gispert, J.-D.
Pascau, J.
Soto-Montenegro, M. L.
Desco, M.
Wang, R.
Wang, G.-J.
Volkow, N. D.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

BACKGROUND: Cervical spine manipulation is one of the many interventions practiced by health professionals to treat musculoskeletal disorders of the cervical spine. Although serious consequences of manipulation have been documented, the incidence is thought to be rare. More frequently, there may be minor transient side effects after manipulation of the cervical spine, such as headache, dizziness, and nausea. One of the hypothesis is that these side effects are caused by ischemia in the areas perfused by the vertebral arteries.

Author(s): 
Cagnie, Barbara
Jacobs, Filip
Barbaix, Erik
Vinck, Elke
Dierckx, Rudi
Cambier, Dirk

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