Raloxifene

Publication Title: 
Chang Gung Medical Journal

BACKGROUND: The plant Cissus quadrangularis (CQ) is used as an osteoprotective agent in Ayurveda, the Indian system of alternative medicine. The present study was done to validate the anti-osteoporotic role of the petroleum ether extract of CQ on ovariectomy-induced osteoporosis in rats. METHODS: Female wistar rats were divided into five groups of six rats each; (1) The Normal control (NC) group (n=6) received no surgery and no treatment, (2).

Author(s): 
Potu, Bhagath Kumar
Rao, Muddanna S.
Nampurath, Gopalan Kutty
Chamallamudi, Mallikarjuna Rao
Nayak, Soubhagya Ranjan
Thomas, Huban
Publication Title: 
Chang Gung Medical Journal

BACKGROUND: The plant Cissus quadrangularis (CQ) is used as an osteoprotective agent in Ayurveda, the Indian system of alternative medicine. The present study was done to validate the anti-osteoporotic role of the petroleum ether extract of CQ on ovariectomy-induced osteoporosis in rats. METHODS: Female wistar rats were divided into five groups of six rats each; (1) The Normal control (NC) group (n=6) received no surgery and no treatment, (2).

Author(s): 
Potu, Bhagath Kumar
Rao, Muddanna S.
Nampurath, Gopalan Kutty
Chamallamudi, Mallikarjuna Rao
Nayak, Soubhagya Ranjan
Thomas, Huban
Publication Title: 
Glia

Steroidal estrogens can regulate inflammatory immune responses and may be involved in the suppression of multiple sclerosis (MS) during pregnancy. However, the risks and side effects associated with steroidal estrogens may limit their usefulness for long-term MS therapy. Selective estrogen receptor modulators (SERMs) could provide an alternative therapeutic strategy, because they behave as estrogen agonists in some tissues, but are either inert or behave like estrogen antagonists in other tissues.

Author(s): 
Bebo, Bruce F.
Dehghani, Babak
Foster, Scott
Kurniawan, Astrid
Lopez, Francisco J.
Sherman, Larry S.
Publication Title: 
Oncogene

Many estrogen receptor (ER)-positive breast cancers respond well initially to endocrine therapies, but often develop resistance during treatment with selective ER modulators (SERMs) such as tamoxifen. We have reported that the 14-3-3 family member and conserved protein, 14-3-3ζ, is upregulated by tamoxifen and that high expression correlated with an early time to disease recurrence. However, the mechanism by which tamoxifen upregulates 14-3-3ζ and may promote the development of endocrine resistance is not known.

Author(s): 
Bergamaschi, A.
Katzenellenbogen, B. S.
Publication Title: 
Orvosi Hetilap

Due to its incidence and clinical consequences osteoporosis followed by vertebral, hip, and forearm fractures represents an outstanding problem of nowadays' health care. Because of its high mortality rate hip fractures are of special interest. The number of fractures caused by postmenopausal osteoporosis increases with age. Costs of examinations and treatment of women with postmenopausal osteoporosis and fractures are also increasing and represent a significant amount all over the world.

Author(s): 
László, Adám
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