Random Allocation

Publication Title: 
Journal of Clinical Epidemiology

BACKGROUND: Systematic reviewers generally evaluate randomized controlled trials (RCTs) based on the published reports. We evaluated whether the description of methods in the published reports is an accurate and complete reflection of study procedures used. METHODS: The authors of 51 RCTs included in a systematic review of acupuncture for chronic pain were sent a brief survey that included questions related to the following three important study quality dimensions: (1) generation of allocation sequence, (2) allocation concealment, and (3) blinding of outcomes assessor.

Manheimer, Eric
Ezzo, Jeanette
Hadhazy, Victoria
Berman, Brian
Publication Title: 
Pharmaceutical Biology

CONTEXT: Terminalia chebula Retz. (Combretaceae) is a medium-sized tree that grows in the wild throughout India. T. chebula has been extensively used in Ayurveda, Unani, and homoeopathic medicine. The fruit has been used as a traditional medicine for a household remedy against various human ailments. Traditionally T. chebula is used to cure chronic ulcer, gastritis, and stomach cancers. OBJECTIVE: The present study is to evaluate the antiulcer effect of hydroalcoholic (70%) extract of Terminalia chebula fruit.

Sharma, Praveen
Prakash, T.
Kotresha, D.
Ansari, Md Asif
Sahrm, Uday Raj
Kumar, Bimlesh
Debnath, Jeevan
Goli, Divakar
Publication Title: 
Alternative Therapies in Health and Medicine

CONTEXT: In India, vaidyas (Ayurvedic physicians) traditionally administer triphala and its constituents as therapeutic agents for promoting digestion and satiety. OBJECTIVE: The research team performed the present study to investigate the effects of triphala and its constituents (T bellirica [bibhitaki], T chebula [haritaki], and E officinalis [amalaki]) on the dietary induction of obesity (diet-induced obesity [DIO]), and other symptoms of visceral obesity syndrome, in mice fed a high-fat diet (HFD).

Gurjar, Shaifali
Pal, Anuradha
Kapur, Suman
Publication Title: 
Biological & Pharmaceutical Bulletin

Avian pathogenic Escherichia coli (APEC) causes inflammation in multiple organs of chickens called avian colibacillosis, and results in serious economic loss to the chicken industry. Polyphenolic compounds possess a wide range of physiological activities that may contribute to their beneficial effects against inflammation-related diseases. In this study, the curative effect and mechanism of action of the polyphenolic extracts from Punica granatum L. and Terminalia chebula Retz. in chickens challenged with APEC were studied.

Zhong, Xinlu
Shi, Yaran
Chen, Jiajia
Xu, Jianqing
Wang, Lei
Beier, Ross C.
Hou, Xiaolin
Liu, Fenghua
Publication Title: 
Child Development

Six match-to-sample picture/object selection experiments were designed to explore children's knowledge about superordinate words (e.g., "food") and how they acquire this knowledge. Three factors were found to influence the learning and extension of superordinate words in 3- to 5-year-old children (N = 230): The number of standards (one versus two), the type of standards presented (from different basic-level categories versus from the same basic-level category), and the nature of the object representations used (pictures versus objects).

Liu, J.
Golinkoff, R. M.
Sak, K.
Publication Title: 
Journal of Pharmacokinetics and Pharmacodynamics

Despite the impact of red blood cell (RBC) Life-spans in some disease areas such as diabetes or anemia of chronic kidney disease, there is no consensus on how to quantitatively best describe the process. Several models have been proposed to explain the elimination process of RBCs: random destruction process, homogeneous life-span model, or a series of 4-transit compartment model. The aim of this work was to explore the different models that have been proposed in literature, and modifications to those.

LledÛ-GarcÌa, RocÌo
Kalicki, Robert M.
Uehlinger, Dominik E.
Karlsson, Mats O.
Publication Title: 
Journal of Proteome Research

Long-term restriction of energy intake without malnutrition is a robust intervention that has been shown to prolong life and delay age-related morbidity. A 1H NMR-based metabonomic strategy was used to monitor urinary metabolic profiles throughout the lifetimes of control-fed and diet-restricted dogs. Urinary metabolic trajectories were constructed for each dog, and metabolic variation was found to be predominantly influenced by age. Urinary excretion of creatinine increased with age, reaching a maximum between ages 5 and 9 years and declining thereafter.

Wang, Yulan
Lawler, Dennis
Larson, Brian
Ramadan, Ziad
Kochhar, Sunil
Holmes, Elaine
Nicholson, Jeremy K.
Publication Title: 
Poultry Science

There is current interest in increasing human vitamin D dietary intake without having to modify human eating habits. One method to increase human dietary vitamin D intake is to generate eggs with increased concentrations of vitamin D through high-concentration vitamin D feeding in the diets of laying hens. Although eggs can be produced with high concentrations of vitamin D, the consequences of these diets on hen performance and egg quality have not been validated.

Persia, M. E.
Higgins, M.
Wang, T.
Trample, D.
Bobeck, E. A.
Publication Title: 
Molecular Psychiatry

Postpartum depression (PPD) affects ?10-18% of women in the general population and results in serious consequences to both the mother and offspring. We hypothesized that predisposition to PPD risk is due to an altered sensitivity to estrogen-mediated epigenetic changes that act in a cell autonomous manner detectable in the blood. We investigated estrogen-mediated epigenetic reprogramming events in the hippocampus and risk to PPD using a cross-species translational design.

Guintivano, J.
Arad, M.
Gould, T. D.
Payne, J. L.
Kaminsky, Z. A.
Publication Title: 
East African Medical Journal

OBJECTIVE: To assess prescribing practice of Primary Health Care (PHC) workers in church owned health care facilities using WHO drug use indicators. DESIGN: A cross-sectional study in which twenty primary health care facilities were randomly selected. Prescribing indicators were obtained by analysing outpatient records retrospectively for the past 14 months between January 1997 and February 1998. This period was chosen because of compete records of outpatient attendances. Patient care and facility indicators were recorded prospectively during the study period.

Massele, A. Y.
Nsimba, S. E.
Rimoy, G.


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