randomized clinical trials

Publication Title: 
Complementary Therapies in Medicine

BACKGROUND: There is no curative treatment for chronic fatigue syndrome (CFS). Traditional Chinese medicine (TCM) is widely used in the treatment of CFS in China. OBJECTIVE: To evaluate the effectiveness and safety of TCM for CFS. METHODS: The protocol of this review is registered at PROSPERO. We searched six main databases for randomized clinical trials (RCTs) on TCM for CFS from their inception to September 2013. The Cochrane risk of bias tool was used to assess the methodological quality. We used RevMan 5.1 to synthesize the results.

Author(s): 
Wang, Yu-Yi
Li, Xin-Xue
Liu, Jian-Ping
Luo, Hui
Ma, Li-Xin
Alraek, Terje
Publication Title: 
International Journal of Epidemiology

BACKGROUND: Blinding patients in clinical trials is a key methodological procedure, but the expected degree of bias due to nonblinded patients on estimated treatment effects is unknown. METHODS: Systematic review of randomized clinical trials with one sub-study (i.e. experimental vs control) involving blinded patients and another, otherwise identical, sub-study involving nonblinded patients. Within each trial, we compared the difference in effect sizes (i.e. standardized mean differences) between the sub-studies.

Author(s): 
Hróbjartsson, Asbjørn
Emanuelsson, Frida
Skou Thomsen, Ann Sofia
Hilden, Jørgen
Brorson, Stig
Publication Title: 
Complementary Therapies in Medicine

BACKGROUND: There is no curative treatment for chronic fatigue syndrome (CFS). Traditional Chinese medicine (TCM) is widely used in the treatment of CFS in China. OBJECTIVE: To evaluate the effectiveness and safety of TCM for CFS. METHODS: The protocol of this review is registered at PROSPERO. We searched six main databases for randomized clinical trials (RCTs) on TCM for CFS from their inception to September 2013. The Cochrane risk of bias tool was used to assess the methodological quality. We used RevMan 5.1 to synthesize the results.

Author(s): 
Wang, Yu-Yi
Li, Xin-Xue
Liu, Jian-Ping
Luo, Hui
Ma, Li-Xin
Alraek, Terje
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