Reagent Kits, Diagnostic

Publication Title: 
PloS One

BACKGROUND: While WHO recently recommended universal parasitological confirmation of suspected malaria prior to treatment, debate has continued as to whether wide-scale use of rapid diagnostic tests (RDTs) can achieve this goal. Adherence of health service personnel to RDT results has been poor in some settings, with little impact on anti-malarial drug consumption. The Senegal national malaria control programme introduced universal parasite-based diagnosis using malaria RDTs from late 2007 in all public health facilities.

Author(s): 
Thiam, Sylla
Thior, Moussa
Faye, Babacar
Ndiop, Medoune
Diouf, Mamadou Lamine
Diouf, Mame Birame
Diallo, Ibrahima
Fall, Fatou Ba
Ndiaye, Jean Louis
Albertini, Audrey
Lee, Evan
Jorgensen, Pernille
Gaye, Oumar
Bell, David
Publication Title: 
Health Policy and Planning

In Uganda, as in many parts of Africa, the majority of the population seek treatment for malaria in drug shops as their first point of care; however, parasitological diagnosis is not usually offered in these outlets. Rapid diagnostic tests (RDTs) for malaria have attracted interest in recent years as a tool to improve malaria diagnosis, since they have proved accurate and easy to perform with minimal training. Although RDTs could feasibly be performed by drug shop vendors, it is not known how much customers would be willing to pay for an RDT if offered in these settings.

Author(s): 
Hansen, Kristian Schultz
Pedrazzoli, Debora
Mbonye, Anthony
Clarke, Siân
Cundill, Bonnie
Magnussen, Pascal
Yeung, Shunmay
Publication Title: 
Parasites & Vectors

BACKGROUND: Treatment of confirmed malaria patients with Artemisinin-based Combination Therapy (ACT) at remote areas is the goal of many anti-malaria programs. Introduction of effective and affordable malaria Rapid Diagnosis Test (RDT) in remote areas could be an alternative tool for malaria case management. This study aimed to assess performance of the OptiMAL dipstick for rapid malaria diagnosis in children under five. METHODS: Malaria symptomatic and asymptomatic children were recruited in a passive manner in two community clinics (CCs).

Author(s): 
Diarra, Amidou
Nébié, Issa
Tiono, Alfred
Sanon, Souleymane
Soulama, Issiaka
Ouédraogo, Alphonse
Gansané, Adama
Yaro, Jean B.
Ouédraogo, Espérance
Traoré, Alfred S.
Sirima, Sodiomon B.
Publication Title: 
PloS One

INTRODUCTION: The World Health Organization Guidelines for the Treatment of Malaria, in 2006 and 2010, recommend parasitological confirmation of malaria before commencing treatment. Although microscopy has been the mainstay of malaria diagnostics, the magnitude of diagnostic scale up required to follow the Guidelines suggests that rapid diagnostic tests (RDTs) will be a large component.

Author(s): 
Zhao, Jinkou
Lama, Marcel
Korenromp, Eline
Aylward, Patrick
Shargie, Estifanos
Filler, Scott
Komatsu, Ryuichi
Atun, Rifat
Publication Title: 
PloS One

BACKGROUND: Despite the benefits of malaria diagnosis, most presumed malaria episodes are never tested. A primary reason is the absence of diagnostic tests in retail establishments, where many patients seek care. Malaria rapid diagnostic tests (RDTs) in drug shops hold promise for guiding appropriate treatment. However, retail providers generally lack awareness of RDTs and training to administer them. Further, unsubsidized RDTs may be unaffordable to patients and unattractive to retailers.

Author(s): 
Cohen, Jessica
Fink, Günther
Berg, Katrina
Aber, Flavia
Jordan, Matthew
Maloney, Kathleen
Dickens, William
Publication Title: 
Malaria Journal

BACKGROUND: Malaria rapid diagnostic tests (RDT) are used for diagnostic purpose in malaria-endemic areas where reliable microscopy is not available. Persistence of the antigenaemia causes over-diagnosis and may limit the usefulness of the RDT in monitoring treatment. In this study, the usefulness of histidine-rich protein-2 (HRP2) and pan-specific or species-specific Plasmodium lactate dehydrogenase (pLDH) in treatment monitoring of uncomplicated falciparum malaria was carried out in an endemic setting in Myanmar.

Author(s): 
Nyunt, Myat H.
Kyaw, Myat P.
Win, Kyu K.
Myint, Khin M.
Nyunt, Khin M.
Publication Title: 
Implementation science: IS

BACKGROUND: Parasitological confirmation is now recommended for all cases of suspected malaria. The roll-out of rapid diagnostic tests (RDTs) is hoped to enable this goal in low resource settings through point of care testing. However, simply making RDTs available has not led to high uptake of the tests or adherence to results by clinicians, with malaria continuing to be overdiagnosed in many settings.

Author(s): 
Chandler, Clare I. R.
Meta, Judith
Ponzo, Célia
Nasuwa, Fortunata
Kessy, John
Mbakilwa, Hilda
Haaland, Ane
Reyburn, Hugh
Publication Title: 
Planta Medica

Although there are inherent and recognized limitations of in vitro screening methodologies to assess conventional drug-drug interactions (DDIs) per industry guidelines and those adopted by independent laboratories, further limitations are being appreciated which are unique to the evaluation of botanical products and potential DDIs in which they may participate.

Author(s): 
Markowitz, John S.
Zhu, Hao-Jie
Publication Title: 
Planta Medica

Although there are inherent and recognized limitations of in vitro screening methodologies to assess conventional drug-drug interactions (DDIs) per industry guidelines and those adopted by independent laboratories, further limitations are being appreciated which are unique to the evaluation of botanical products and potential DDIs in which they may participate.

Author(s): 
Markowitz, John S.
Zhu, Hao-Jie

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