Receptor Protein-Tyrosine Kinases

Publication Title: 
Open Biology

Multi-cellular organisms need to successfully link cell growth and metabolism to environmental cues during development. Insulin receptor-target of rapamycin (InR-TOR) signalling is a highly conserved pathway that mediates this link. Herein, we describe poly, an essential gene in Drosophila that mediates InR-TOR signalling. Loss of poly results in lethality at the third instar larval stage, but only after a stage of extreme larval longevity.

Author(s): 
Bolukbasi, Ekin
Vass, Sharron
Cobbe, Neville
Nelson, Bryce
Simossis, Victor
Dunbar, Donald R.
Heck, Margarete M. S.
Publication Title: 
Advances in Gerontology = Uspekhi Gerontologii / Rossi?skai?a Akademii?a Nauk, Gerontologicheskoe Obshchestvo

It is well known that dietary restriction (DR) may substantially affect the life span (LS) of various model organisms including Drosophila melanogaster. In our recent studies, it has been revealed that the reduction of the content of main nutrients in larval medium may lead to an increase of flies' LS. Analysis of these data suggested that the most likely candidate for such long-term adaptive changes is insects' epigenome (i.e., persistent changes in the activity of genes that are not related to changes in the DNA structure).

Author(s): 
Va?serman, A. M.
Koliada, A. K.
Zabuga, O. G.
Publication Title: 
Blood

Human protein S is an anticoagulation protein. However, it is unknown whether protein S could regulate the expression and function of macrophage scavenger receptor A (SR-A) in macrophages. Human THP-1 monocytes and peripheral blood monocytes were differentiated into macrophages and then treated with physiological concentrations of human protein S. We found that protein S significantly reduced acetylated low-density lipoprotein (AcLDL) uptake and binding by macrophages and decreased the intracellular cholesteryl ester content.

Author(s): 
Liao, Dan
Wang, Xinwen
Li, Min
Lin, Peter H.
Yao, Qizhi
Chen, Changyi
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