Receptors, Adrenergic, alpha-1

Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

Epigenetic regulation may be involved in the pathophysiology of mental disorders, such as schizophrenia and bipolar disorder, and in the pharmacological action of drugs. Characterizing the epigenetic effects of drugs is an important step to optimal treatment. We performed comprehensive and gene-specific DNA methylation analyses of quetiapine using human neuroblastoma cells. Human neuroblastoma cells were cultured with quetiapine for 8 days, and DNA methylation analysis was performed using Infinium HumanMethylation27 BeadChip. A total of 1173 genes showed altered DNA methylation.

Author(s): 
Sugawara, Hiroko
Bundo, Miki
Asai, Tatsuro
Sunaga, Fumiko
Ueda, Junko
Ishigooka, Jun
Kasai, Kiyoto
Kato, Tadafumi
Iwamoto, Kazuya
Publication Title: 
PloS One

Acute stress affects cellular integrity in many tissues including the liver, but its underlying mechanism is still unclear. The aim of the present study was to investigate the potential involvement of catecholamines and adrenoceptors in the regulation of acute restraint stress-induced liver injury. Restraint was achieved by placing mice in restraint tubes.

Author(s): 
Zhu, Qing
Gu, Liwei
Wang, Yimei
Jia, Li
Zhao, Zengming
Peng, Shuangqing
Lei, Linsheng
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Ephedra species of plants have both beneficial and adverse effects primarily associated with the presence of ephedrine alkaloids. Few reports have appeared that examine the direct actions of ephedrine alkaloids on human subtypes of adrenergic receptors (ARs). In the present study, ephedrine alkaloids were evaluated for their binding affinities on human alpha(1A)-, alpha(1B)-, alpha(1D)-, alpha(2A)-, alpha(2B)-, and alpha(2C)-AR subtypes expressed in HEK and Chinese hamster ovary cells.

Author(s): 
Ma, Guoyi
Bavadekar, Supriya A.
Davis, Yolande M.
Lalchandani, Shilpa G.
Nagmani, Rangaswamy
Schaneberg, Brian T.
Khan, Ikhlas A.
Feller, Dennis R.
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Ischemic preconditioning (PC) has been proposed as an endogenous form of protection against-ischemia reperfusion injury. We have shown that PC does not prevent postischemic dysfunction in the aging heart. This phenomenon could be due to the reduction of cardiac norepinephrine release, and it has also been previously demonstrated that age-related decrease of norepinephrine release from cardiac adrenergic nerves may be restored by caloric restriction.

Author(s): 
Abete, Pasquale
Testa, Gianluca
Ferrara, Nicola
de Santis, Domenico
Capaccio, Pina
Viati, Luisa
Calabrese, Claudio
Cacciatore, Francesco
Longobardi, Giancarlo
Condorelli, Mario
Napoli, Claudio
Rengo, Franco
Publication Title: 
Chinese Medical Journal

BACKGROUND: Chronic heart failure (CHF) had been characterized as an activated sympathetic system leading to the alteration of adrenergic receptor (AR) levels in the heart. Thus far, not much research has been done with regard to traditional Chinese medical treatment for CHF. We investigated the effect of Shexiangbaoxin pills (SXBXP) on the function of the heart and the expression of a(1)-AR and b-AR subtypes in the messenger RNA (mRNA) levels and protein levels of non-infarction left ventricular tissue from rats with CHF induced by myocardial infarction.

Author(s): 
Li, Yan-Fang
Cao, Fang-Fang
Liu, Fei
Bai, Xue-Yuan
Lu, Yang
Publication Title: 
Reproductive biology and endocrinology: RB&E

BACKGROUND: Estradiol valerate (EV)-induced polycystic ovaries (PCO) in rats is associated with an increase in ovarian sympathetic outflow. Low-frequency (2 Hz) electro-acupuncture (EA) has been shown to modulate sympathetic markers as well as ovarian blood flow as a reflex response via the ovarian sympathetic nerves, in rats with EV-induced PCO. METHODS: In the present study, we further tested the hypothesis that repeated 2 Hz EA treatments modulate ovarian sympathetic outflow in rats with PCO, induced by a single i.m.

Author(s): 
Manni, Luigi
Lundeberg, Thomas
Holmäng, Agneta
Aloe, Luigi
Stener-Victorin, Elisabet
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