Receptors, Adrenergic, alpha-2

Publication Title: 
Neuro Endocrinology Letters

OBJECTIVES: Increasing evidences support the importance of epigenetic control in schizophrenia pathogenesis. One of the enzymes involved in DNA methylation process through homocysteine metabolism is methylenetetrahydrofolate reductase (MTHFR). The most extensively studied variant in the MTHFR gene is the C677T polymorphism, resulting in reduced enzyme activity and elevated homocysteine level. METHODS: In sample of 192 schizophrenics and 213 healthy controls an increasing risk of schizophrenia associated with MTHFR 677 CT+TT genotype was found (OR=1.6, p=0.021).

Author(s): 
Lochman, Jan
PlesnÌk, Ji?Ì
Janout, VladimÌr
Povov·, Jana
MÌöek, Ivan
Dvo?·kov·, Dagmar
äer˝, Omar
Publication Title: 
The European Journal of Neuroscience

How external stimuli prevent the onset of sleep has been little studied. This is usually considered to be a non-specific type of phenomenon. However, the hypnotic drug dexmedetomidine, an agonist at ?2 adrenergic receptors, has unusual properties that make it useful for investigating this question. Dexmedetomidine is considered to produce an 'arousable' sleep-like state, so that patients or animals given dexmedetomidine become alert following modest stimulation.

Author(s): 
Gelegen, Cigdem
Gent, Thomas C.
Ferretti, Valentina
Zhang, Zhe
Yustos, Raquel
Lan, Fei
Yang, Qianzi
Overington, Dorothy W. U.
Vyssotski, Alexei L.
van Lith, Hein A.
Wisden, William
Franks, Nicholas P.
Publication Title: 
PloS One

Acute stress affects cellular integrity in many tissues including the liver, but its underlying mechanism is still unclear. The aim of the present study was to investigate the potential involvement of catecholamines and adrenoceptors in the regulation of acute restraint stress-induced liver injury. Restraint was achieved by placing mice in restraint tubes.

Author(s): 
Zhu, Qing
Gu, Liwei
Wang, Yimei
Jia, Li
Zhao, Zengming
Peng, Shuangqing
Lei, Linsheng
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Ephedra species of plants have both beneficial and adverse effects primarily associated with the presence of ephedrine alkaloids. Few reports have appeared that examine the direct actions of ephedrine alkaloids on human subtypes of adrenergic receptors (ARs). In the present study, ephedrine alkaloids were evaluated for their binding affinities on human alpha(1A)-, alpha(1B)-, alpha(1D)-, alpha(2A)-, alpha(2B)-, and alpha(2C)-AR subtypes expressed in HEK and Chinese hamster ovary cells.

Author(s): 
Ma, Guoyi
Bavadekar, Supriya A.
Davis, Yolande M.
Lalchandani, Shilpa G.
Nagmani, Rangaswamy
Schaneberg, Brian T.
Khan, Ikhlas A.
Feller, Dennis R.
Publication Title: 
British Journal of Anaesthesia

BACKGROUND: Although acupuncture analgesia is well documented, its mechanisms have not been thoroughly clarified. We previously showed that electroacupuncture (EA) activates supraspinal serotonin- and norepinephrine-containing neurones that project to the spinal cord. This study investigates the involvement of spinal alpha(2)-adrenoceptors (α2-ARs) and 5-hydroxytryptamine (serotonin) receptors (5-HTRs) in EA effects on an inflammatory pain rat model.

Author(s): 
Zhang, Y.
Zhang, R. X.
Zhang, M.
Shen, X. Y.
Li, A.
Xin, J.
Ren, K.
Berman, B. M.
Tan, M.
Lao, L.
Publication Title: 
NeuroImage

BACKGROUND/AIMS: Alterations in noradrenergic (NE) signaling have been implicated in the pathophysiology of irritable bowel syndrome (IBS), and adrenergic receptors are potential treatment targets. METHODS: To characterize central NE signaling in IBS, 11 patients and 11 healthy controls (HCs) were studied 3 times during an auditory oddball vigilance task after double-blind ingestion of the α2-adrenoreceptor (α2AR) antagonist yohimbine (YOH), the α2AR agonist clonidine (CLO), or placebo (PLA).

Author(s): 
Berman, Steven
Suyenobu, Brandall
Naliboff, Bruce D.
Bueller, Joshua
Stains, Jean
Wong, Heng
Mandelkern, Mark
Fitzgerald, Leah
Ohning, Gordon
Gupta, Arpana
Labus, Jennifer S.
Tillisch, Kirsten
Mayer, Emeran A.
Publication Title: 
Neuroscience Letters

Dexmedetomidine, a selective alpha 2-adrenoceptor (α2AR) agonist, has provided significant analgesia in neuropathic pain. However, its underlying molecular mechanism has not been fully elucidated. In the present study, we found that intrathecal administration of dexmedetomidine alleviated mechanical allodynia induced by chronic constriction injury (CCI), and pretreatment with BRL44408 significantly reversed the dexmedetomidine-induced anti-nociceptive effect.

Author(s): 
Li, Shuang-Shuang
Zhang, Wei-Shi
Ji, Dong
Zhou, Ya-Lan
Li, Hui
Yang, Jia-Le
Xiong, Yuan-Chang
Zhang, Yu-Qiu
Xu, Hua
Publication Title: 
British Journal of Anaesthesia

BACKGROUND: Although acupuncture analgesia is well documented, its mechanisms have not been thoroughly clarified. We previously showed that electroacupuncture (EA) activates supraspinal serotonin- and norepinephrine-containing neurones that project to the spinal cord. This study investigates the involvement of spinal alpha(2)-adrenoceptors (α2-ARs) and 5-hydroxytryptamine (serotonin) receptors (5-HTRs) in EA effects on an inflammatory pain rat model.

Author(s): 
Zhang, Y.
Zhang, R. X.
Zhang, M.
Shen, X. Y.
Li, A.
Xin, J.
Ren, K.
Berman, B. M.
Tan, M.
Lao, L.
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