Receptors, AMPA

Publication Title: 
Molecular Psychiatry

Adenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals. Little is known about human A-to-I editing, but it is thought to constitute one of many molecular mechanisms connecting environmental stimuli and behavioral outputs. Thus, comprehensive exploration of A-to-I RNA editing in human brains may shed light on gene-environment interactions underlying complex behavior in health and disease.

Author(s): 
Eran, A.
Li, J. B.
Vatalaro, K.
McCarthy, J.
Rahimov, F.
Collins, C.
Markianos, K.
Margulies, D. M.
Brown, E. N.
Calvo, S. E.
Kohane, I. S.
Kunkel, L. M.
Publication Title: 
Alcoholism, Clinical and Experimental Research

BACKGROUND: The glutamate system plays a major role in mediating EtOH's effects on brain and behavior, and is implicated in the pathophysiology of alcohol-related disorders. N-methyl-D-aspartate receptor (NMDAR) antagonists such as MK-801 (dizocilpine) interact with EtOH at the behavioral level, but the molecular basis of this interaction is unclear. METHODS: We first characterized the effects of MK-801 treatment on responses to the ataxic (accelerating rotarod), hypothermic and sedative/hypnotic effects of acute EtOH administration in C57BL/6J and 129/SvImJ inbred mice.

Author(s): 
Palachick, Benjamin
Chen, Yi-Chyan
Enoch, Abigail J.
Karlsson, Rose-Marie
Mishina, Masayoshi
Holmes, Andrew
Publication Title: 
Basic & Clinical Pharmacology & Toxicology

The present study was designed to investigate the role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hypnosis and analgesia induced by emulsified inhalation anaesthetics. After having established the mice model of hypnosis and analgesia by intraperitoneally injecting appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we intracerebroventricularly or intrathecally injected different doses of AMPA and then observed the effects on the sleep time using hypnosis test and the tail-withdrawal latency using the tail-withdrawal test.

Author(s): 
Hang, Lihua
Shao, Donghua
Yang, Yinghong
Sun, Wenjin
Dai, Tijun
Zeng, Yinming
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Anesthesiologists among physicians are on the top of the drug abuse list, and the mechanism is unclear. Recent studies suggest occupation-related second-hand exposure to i.v. drugs, including propofol, may play a role. Growing evidence indicates that propofol is one of the choices of drugs being abused. In this study, we show that propofol at minute concentrations increases glutamatergic excitatory synaptic transmission and discharges of dopamine neurons in the ventral tegmental area (VTA).

Author(s): 
Li, Ke-yong
Xiao, Cheng
Xiong, Ming
Delphin, Ellise
Ye, Jiang-Hong
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

NMDA receptor-dependent long-term potentiation (LTP) and depression (LTD) are forms of synaptic plasticity underlying learning and memory that are expressed through increases and decreases, respectively, in dendritic spine size and AMPA receptor (AMPAR) phosphorylation and postsynaptic localization. The A-kinase anchoring protein 79/150 (AKAP79/150) signaling scaffold regulates AMPAR phosphorylation, channel activity, and endosomal trafficking associated with LTP and LTD.

Author(s): 
Keith, Dove J.
Sanderson, Jennifer L.
Gibson, Emily S.
Woolfrey, Kevin M.
Robertson, Holly R.
Olszewski, Kyle
Kang, Rujun
El-Husseini, Alaa
Dell'acqua, Mark L.
Publication Title: 
Experimental Neurology

Caloric restriction (CR) extends life span and ameliorates the aging-related decline in hippocampal-dependent cognitive function. In the present study, we compared subunit levels of NMDA and AMPA types of the glutamate receptor and quantified total synapses and multiple spine bouton (MSB) synapses in hippocampal CA1 from young (10 months), middle-aged (18 months), and old (29 months) Fischer 344xBrown Norway rats that were ad libitum (AL) fed or caloric restricted (CR) from 4 months of age. Each of these parameters has been reported to be a potential contributor to hippocampal function.

Author(s): 
Shi, Lei
Adams, Michelle M.
Linville, M. Constance
Newton, Isabel G.
Forbes, M. Elizabeth
Long, Ashley B.
Riddle, David R.
Brunso-Bechtold, Judy K.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: Recent experimental evidence demonstrating neuronal/synaptic plasticity and, in particular, long-term potentiation (LTP) and long-term depression (LTD) in spinal neurons is reviewed. The implications of these studies for possible mechanistic explanations of low back pain and its remediation by spinal manipulative therapy (SMT) are explored. Brief descriptions of LTP and LTD and elaboration of the key roles of calcium, glutamate, and glutamate receptors in LTP/LTD are provided as separate appendices.

Author(s): 
Boal, Robert W.
Gillette, Richard G.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: Recent experimental evidence demonstrating neuronal/synaptic plasticity and, in particular, long-term potentiation (LTP) and long-term depression (LTD) in spinal neurons is reviewed. The implications of these studies for possible mechanistic explanations of low back pain and its remediation by spinal manipulative therapy (SMT) are explored. Brief descriptions of LTP and LTD and elaboration of the key roles of calcium, glutamate, and glutamate receptors in LTP/LTD are provided as separate appendices.

Author(s): 
Boal, Robert W.
Gillette, Richard G.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The Daming capsule (DMC) is a traditional Chinese medicine used to treat hyperlipoidemia. Both clinic trials and studies on animal models have demonstrated that DMC is beneficial against diabetic symptoms. Impairment of the baroreflex can cause life-threatening arrhythmias and sudden cardiac death in patients with diabetes mellitus (DM). This study was designed to elucidate the effects of DMC on baroreflexes in streptozocin (STZ)-induced diabetic rats with hyperlipoidemia.

Author(s): 
Ai, Jing
Wang, Li-Hong
Zhang, Rong
Qiao, Guo-Fen
Wang, Ning
Sun, Li-hua
Lu, Guan-Yi
Sun, Chao
Yang, Bao-Feng
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