Receptors, Antigen, T-Cell, gamma-delta

Publication Title: 
Critical Reviews in Immunology

Many pharmaceutical drugs arc isolated from plants used in traditional medicines, and new plant-derived pharmaceutical drugs continue to be identified. Relevant to this review, different plant-derived agonists for gammadelta T cells are described that impart effector functions upon distinct subsets of these cells. Recently, plant tannins have been defined as one class of gammadelta T cell agonist and appear to preferentially activate the mucosal population. Mucosal gammadelta T cells function to modulate tissue immune responses and induce epithelium repair.

Author(s): 
Holderness, Jeff
Hedges, Jodi F.
Daughenbaugh, Katie
Kimmel, Emily
Graff, Jill
Freedman, Brett
Jutila, Mark A.
Publication Title: 
PloS One

γδ T cells have been postulated to act as a first line of defense against infectious agents, particularly intracellular pathogens, representing an important link between the innate and adaptive immune responses. Human γδ T cells expand in the blood of brucellosis patients and are active against Brucella in vitro. However, the role of γδ T cells in vivo during experimental brucellosis has not been studied. Here we report TCRδ(-/-) mice are more susceptible to B. abortus infection than C57BL/6 mice at one week post-infection as measured by splenic colonization and splenomegaly.

Author(s): 
Skyberg, Jerod A.
Thornburg, Theresa
Rollins, Maryclare
Huarte, Eduardo
Jutila, Mark A.
Pascual, David W.
Publication Title: 
Comparative Immunology, Microbiology and Infectious Diseases

We characterized immune modulating functions of porcine γδ T cell subsets in rotavirus infection using a gnotobiotic pig model of human rotavirus infection and sort-purified lymphocyte autologous co-cultures. We demonstrated that CD2+CD8- and CD2-CD8- γδ T cells have mainly pro-inflammatory function as evident by directly secreting IFN-γ or promoting CD4+ αβ T cell proliferation and IFN-γ production, whereas CD2+CD8+ γδ T cells mainly exert regulatory T cell function by expressing FoxP3, secreting IL-10 and TGF-β or increasing IL-10 and TGF-β production by CD4+ αβ T cells.

Author(s): 
Wen, Ke
Bui, Tammy
Li, Guohua
Liu, Fangning
Li, Yanru
Kocher, Jacob
Yuan, Lijuan
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Solute carrier 11A1 (SLC11A1) is a divalent ion transporter formerly known as the natural resistance-associated macrophage protein (NRAMP1) and the Bcg/Lsh/Ity locus. SLC11A1 was thought to be exclusively expressed in monocyte/macrophages and to have roles in phagosome maturation and cell activation. We characterized the expression of SLC11A1 in the majority of human and bovine γδ T cells and NK cells and in human CD3(+)CD45RO(+) T cells.

Author(s): 
Hedges, Jodi F.
Kimmel, Emily
Snyder, Deann T.
Jerome, Maria
Jutila, Mark A.
Publication Title: 
Cancer immunology, immunotherapy: CII

Polysaccharide K (PSK) is a widely used mushroom extract that has shown anti-tumor and immunomodulatory effects in both preclinical and clinical studies. Therefore, it is important to understand the mechanism of actions of PSK. We recently reported that PSK can activate toll-like receptor 2 and enhances the function of NK cells. The current study was undertaken to study the effect of PSK on gamma delta (γδ) T cells, another important arm of the innate immunity.

Author(s): 
Inatsuka, Carol
Yang, Yi
Gad, Ekram
Rastetter, Lauren
Disis, Mary L.
Lu, Hailing
Publication Title: 
Journal of Neuroimmunology

To explore the hypothesis that gammadelta T cells may regulate activated alphabeta T cells, we studied gammadelta T cell responses to alphabeta T cell clones in Multiple Sclerosis (MS) patients who received attenuated autologous autoreactive T cells. We recently conducted a pilot study of T cell vaccination with myelin basic protein reactive T cells in MS. Since T cell vaccination upregulates the anti-vaccine T cell responses, we evaluated gammadelta T cell reactivity towards the vaccine in the vaccinated patients.

Author(s): 
Stinissen, P.
Zhang, J.
Vandevyver, C.
Hermans, G.
Raus, J.
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