Receptors, Serotonin, 5-HT3

Publication Title: 
Depression and Anxiety

BACKGROUND: Serotonin 3A receptor (5-HT3A R) is associated at the genetic and epigenetic levels with a variety of psychiatric disorders and interacts with early-life stress such as childhood maltreatment. We studied the impact of childhood maltreatment on the methylation status of the 5-HT3A R and its association with clinical severity outcomes in relation with a functional genetic polymorphism.

Author(s): 
Perroud, Nader
Zewdie, Seblewongel
Stenz, Ludwig
Adouan, Wafae
Bavamian, Sabine
Prada, Paco
Nicastro, Rosetta
Hasler, Roland
Nallet, Audrey
Piguet, Camille
Paoloni-Giacobino, Ariane
Aubry, Jean-Michel
Dayer, Alexandre
Publication Title: 
European Journal of Pharmacology

Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate (TG41) enhanced the binding both of gamma-aminobutyric acid (GABA) and of flunitrazepam to rat cerebral cortical membranes. Electrophysiological recordings from Xenopus oocytes expressing various recombinant GABA(A) receptor subtypes revealed that TG41 enhanced the function of all receptor subunit combinations tested. The potency of TG41 at receptors containing alpha1, beta2, and gamma2L subunits was greater than that of alphaxalone, etomidate, propofol, or pentobarbital.

Author(s): 
Mascia, Maria Paola
Asproni, Battistina
Busonero, Fabio
Talani, Giuseppe
Maciocco, Elisabetta
Pau, Amedeo
Cerri, Riccardo
Sanna, Enrico
Biggio, Giovanni
Publication Title: 
Pharmacological reports: PR

In the present study, we investigated the role of 5-hydroxytryptamine type 3 (5-HT(3)) receptors in hypnosis and analgesia induced by emulsified sevoflurane. A mouse model of hypnosis and analgesia was established by an intraperitoneal or subcutaneous injection of emulsified sevoflurane.We intracerebroventricularly (i.c.v.) or intrathecally (i.t.) administered YM-31636, a 5-HT(3) receptor agonist, to mice and observed sleep time during hypnosis.

Author(s): 
Hang, Li-Hua
Shao, Dong-Hua
Wang, Hong
Yang, Jian-Ping
Publication Title: 
Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre

OBJECTIVE: The present study was undertaken to evaluate the antinociceptive effects of an ayurvedic polyherbal formulation in rats and mice employing the tail immersion test and acetic acid-induced writhing test, respectively.

Author(s): 
Chandrasekar, S. B.
Divakar, Kalyani
Pawar, A. T.
Goli, Divakar
Harisha, R.
Bhanumathy, M.
Sushma, G.
Shivaprasad, H. N.
Publication Title: 
Neurochemical Research

Bacopa monniera is a well-known medhya-rasayana (memory enhancing and rejuvenating) plant in Indian traditional medical system of Ayurveda. The effect of a standardized extract of Bacopa monniera (BESEB CDRI-08) on serotonergic receptors and its influence on other neurotransmitters during hippocampal-dependent learning was evaluated in the present study.

Author(s): 
Rajan, Koilmani Emmanuvel
Singh, Hemant K.
Parkavi, Arunagiri
Charles, Prisila Dulcy
Publication Title: 
Alcoholism, Clinical and Experimental Research

This report of the proceedings of a symposium presented at the 2005 annual meeting of the Research Society on Alcoholism highlights the actions of ethanol on purinergic (P2XRs) and 5-hydroxytryptamine3 (5-HT3Rs) receptors. Both P2XRs and 5-HT3Rs, are modulated by pharmacologically relevant concentrations of ethanol, with inhibition or stimulation of P2XR subtypes and stimulation of 5-HT3Rs, respectively. With regard to ethanol-modulatory actions, these 2 distinctly different receptor classes have been studied to a much lesser extent than other LGICs. The organizers and chairs were Daryl L.

Author(s): 
Davies, Daryl L.
Asatryan, Liana
Kuo, Sacha T.
Woodward, John J.
King, Brian F.
Alkana, Ronald L.
Xiao, Cheng
Ye, Jiang Hong
Sun, Hui
Zhang, Li
Hu, Xiang-Qun
Hayrapetyan, Volodya
Lovinger, David M.
Machu, Tina K.
Publication Title: 
Alimentary Pharmacology & Therapeutics

BACKGROUND: The importance of bi-directional brain-gut interactions in gastrointestinal illness is increasingly being recognized, most prominently in the area of functional gastrointestinal disorders. Numerous current and emerging therapies aimed at normalizing brain-gut interactions are a focus of interest, particularly for irritable bowel syndrome and functional dyspepsia. METHODS: A literature search was completed for preclinical and clinical studies related to central modulation of gastrointestinal functions and published in English between 1980 and 2006.

Author(s): 
Mayer, E. A.
Tillisch, K.
Bradesi, S.
Publication Title: 
Gastroenterology

BACKGROUND & AIMS: 5-Hydroxytryptamine (5-HT)3 receptor (5-HT3R) antagonists are effective in treating patients with irritable bowel syndrome (IBS) and have anxiolytic effects. Their therapeutic effects are related, in part, to reducing amygdala engagement during expected visceral pain. A single nucleotide polymorphism in HTR3A, c.-42C>T;(C178T; rs1062613), is associated with altered reactivity of the amygdala during emotional face processing in healthy subjects (controls).

Author(s): 
Kilpatrick, Lisa A.
Labus, Jennifer S.
Coveleskie, Kristen
Hammer, Christian
Rappold, Gudrun
Tillisch, Kirsten
Bueller, Joshua A.
Suyenobu, Brandall
Jarcho, Johana M.
McRoberts, Jim A.
Niesler, Beate
Mayer, Emeran A.
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