Reference Values

Publication Title: 
Psychosomatic Medicine

BACKGROUND: Leukocyte telomere shortening can serve as a biomarker of aging, as telomere length (TL) can decline with age and shortening is positively associated with morbidity and mortality. It is therefore important to identify psychological and behavioral factors linked to accelerated telomere shortening. Stress and poorer metabolic health (greater adiposity, insulin resistance, and cortisol) correlate with shorter telomeres.

Author(s): 
Kiefer, Amy
Lin, Jue
Blackburn, Elizabeth
Epel, Elissa
Publication Title: 
Psychoneuroendocrinology

Allostatic load, the physiological accumulation of the effects of chronic stressors, has been associated with multiple adverse health outcomes. Flattened diurnal cortisol rhythmicity is one of the prototypes of allostatic load, and has been shown to predict shorter survival among women with metastatic breast cancer. The current study compared diurnal cortisol slope in 17 breast cancer patients and 31 controls, and tested associations with variables previously found to be related to cortisol regulation, i.e, abdominal adiposity, perceived stress, social support, and explicit memory.

Author(s): 
Abercrombie, Heather C.
Giese-Davis, Janine
Sephton, Sandra
Epel, Elissa S.
Turner-Cobb, Julie M.
Spiegel, David
Publication Title: 
Psychosomatic Medicine

BACKGROUND: Leukocyte telomere shortening can serve as a biomarker of aging, as telomere length (TL) can decline with age and shortening is positively associated with morbidity and mortality. It is therefore important to identify psychological and behavioral factors linked to accelerated telomere shortening. Stress and poorer metabolic health (greater adiposity, insulin resistance, and cortisol) correlate with shorter telomeres.

Author(s): 
Kiefer, Amy
Lin, Jue
Blackburn, Elizabeth
Epel, Elissa
Publication Title: 
Psychoneuroendocrinology

We previously reported that psychological stress is linked to and possibly accelerates cellular aging, as reflected by lower PBMC telomerase and shortened telomeres. Psychological stress is a major risk factor for cardiovascular disease (CVD), with multiple behavioral and physiological mediators. Telomere shortness has been associated with CVD, but the relationship between low telomerase activity, a potential precursor to telomere shortening, and CVD risk factors has not been examined in humans.

Author(s): 
Epel, Elissa S.
Lin, Jue
Wilhelm, Frank H.
Wolkowitz, Owen M.
Cawthon, Richard
Adler, Nancy E.
Dolbier, Christyn
Mendes, Wendy B.
Blackburn, Elizabeth H.
Publication Title: 
Molecular Psychiatry

Epigenetic genome modifications such as DNA methylation appear to be involved in various diseases. Here, we suggest that the levels of DNA methylation at the BssHII methylation-sensitive restriction enzyme sites in the human REELIN (RELN) gene in the forebrain vary among individuals. Interestingly, although a statistically significant correlation between the levels of DNA methylation in RELN and age was detected in healthy individuals, no such correlations were seen in either schizophrenic or bipolar patients.

Author(s): 
Tamura, Y.
Kunugi, H.
Ohashi, J.
Hohjoh, H.
Publication Title: 
Psychoneuroendocrinology

Disturbances of volume regulating peptides like vasopressin and atrial natriuretic peptide (ANP) have been described in early abstinent patients. Aim of the present study was to evaluate possible alterations of the promoter-related DNA methylation of the ANP and vasopressin precursor genes and the related mRNA-expression of these genes in early alcohol withdrawal. We analyzed blood samples of 57 healthy controls and of 111 patients suffering from alcohol dependence that were admitted for detoxification treatment.

Author(s): 
Hillemacher, Thomas
Frieling, Helge
Luber, Katja
Yazici, Ayfer
Muschler, Marc A. N.
Lenz, Bernd
Wilhelm, Julia
Kornhuber, Johannes
Bleich, Stefan
Publication Title: 
Journal of Affective Disorders

BACKGROUND: Bipolar disorder is a complex disorder hypothesized to involve an interaction of multiple susceptibility genes and environmental factors. The environmental factors may be mediated via epigenetic mechanisms such as DNA methylation. Since a different extent of DNA methylation has recently been reported in lymphoblastoid cells derived from monozygotic twins discordant for bipolar disorder, we hypothesized that bipolar patients exhibit a different extent of leukocyte global DNA methylation compared with healthy controls.

Author(s): 
Bromberg, A.
Bersudsky, Y.
Levine, J.
Agam, G.
Publication Title: 
Translational Psychiatry

Chromosome 22q11.2 deletion syndrome (22q11DS) is the most common microdeletion syndrome in humans. It is typified by highly variable symptoms, which might be explained by epigenetic regulation of genes in the interval. Using computational algorithms, our laboratory previously predicted that DiGeorge critical region 6 (DGCR6), which lies within the deletion interval, is imprinted in humans. Expression and epigenetic regulation of this gene have not, however, been examined in 22q11DS subjects.

Author(s): 
Das Chakraborty, R.
Chakraborty, D.
Bernal, A. J.
Schoch, K.
Howard, T. D.
Ip, E. H.
Hooper, S. R.
Keshavan, M. S.
Jirtle, R. L.
Shashi, V.
Publication Title: 
Journal of Crohn's & Colitis

BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) are heterogeneous disorders with complex aetiology. Quantitative genetic studies suggest that only a small proportion of the disease variance observed in IBD is accounted for by genetic variation, indicating a potential role for differential epigenetic regulation in disease aetiology. The aim of this study was to assess genome-wide DNA methylation changes specifically associated with ulcerative colitis (UC), Crohn's disease (CD) and IBD activity.

Author(s): 
McDermott, Edel
Ryan, Elizabeth J.
Tosetto, Miriam
Gibson, David
Burrage, Joe
Keegan, Denise
Byrne, Kathryn
Crowe, Eimear
Sexton, Gillian
Malone, Kevin
Harris, R. Alan
Kellermayer, Richard
Mill, Jonathan
Cullen, Garret
Doherty, Glen A.
Mulcahy, Hugh
Murphy, Therese M.
Publication Title: 
The Diabetes Educator

PURPOSE: The purpose of this randomized controlled trial is to determine the effectiveness of an intervention led by promotoras (community lay workers) on the glycemic control, diabetes knowledge, and diabetes health beliefs of Mexican Americans with type 2 diabetes living in a major city on the Texas-Mexico border. METHODS: One hundred fifty Mexican American participants were recruited at a Catholic faith-based clinic and randomized into 2 groups. Personal characteristics, acculturation, baseline A1C level, diabetes knowledge, and diabetes health beliefs were measured.

Author(s): 
Lujan, Josefina
Ostwald, Sharon K.
Ortiz, Melchor

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