Rejuvenation

Publication Title: 
Aesthetic Surgery Journal

BACKGROUND: Although aesthetic correction of facial aging had long been the exclusive domain of plastic surgeons and dermatologists, alternative nonmedical approaches to facial rejuvenation are becoming more popular, such as facial acupuncture, facial acupressure, and facial exercises. However, the effectiveness of these alternative approaches is still a topic of debate. OBJECTIVES: The authors review the evidence of the effectiveness of facial exercises for facial rejuvenation.

Author(s): 
Van Borsel, John
De Vos, Marie-Camille
Bastiaansen, Karen
Welvaert, Jaira
Lambert, Jo
Publication Title: 
Aesthetic Surgery Journal

BACKGROUND: Although aesthetic correction of facial aging had long been the exclusive domain of plastic surgeons and dermatologists, alternative nonmedical approaches to facial rejuvenation are becoming more popular, such as facial acupuncture, facial acupressure, and facial exercises. However, the effectiveness of these alternative approaches is still a topic of debate. OBJECTIVES: The authors review the evidence of the effectiveness of facial exercises for facial rejuvenation.

Author(s): 
Van Borsel, John
De Vos, Marie-Camille
Bastiaansen, Karen
Welvaert, Jaira
Lambert, Jo
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Shilajit is a multi-component natural occurring mineral substance used in Ayurveda and Siddha systems of medicine which originated in India. Its source can be traced to the mountainous regions, where the hilly tribes first identified its beneficial use. Shilajit is aptly referred to as 'rasayana'/'rasayanam' in Ayurveda and Siddha literature which means rejuvenator because it prevents ailment and enhances the quality of life.

Author(s): 
Wilson, Eugene
Rajamanickam, G. Victor
Dubey, G. Prasad
Klose, Petra
Musial, Frauke
Saha, F. Joyonto
Rampp, Thomas
Michalsen, Andreas
Dobos, Gustav J.
Publication Title: 
Experimental Gerontology

Homeostasis is a key feature of the cellular lifespan. Its maintenance influences the rate of ageing and it is determined by several factors, including efficient proteolysis. The proteasome is the major cellular proteolytic machinery responsible for the degradation of both normal and damaged proteins. Alterations of proteasome function have been recorded in various biological phenomena including ageing and replicative senescence.

Author(s): 
Chondrogianni, Niki
Kapeta, Suzanne
Chinou, Ioanna
Vassilatou, Katerina
Papassideri, Issidora
Gonos, Efstathios S.
Publication Title: 
Current Opinion in Cell Biology

Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a striking increase in a wide range of diseases. The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) opens new avenues for the aging field and has important applications for therapeutic treatments of age-related diseases. Here we review emerging studies on how aging and age-related pathways influence iPSC generation and property.

Author(s): 
Mahmoudi, Salah
Brunet, Anne
Publication Title: 
Aging

Very small embryonic-like stem cells (VSELs) are a population of developmentally early stem cells residing in adult tissues. These rare cells, which are slightly smaller than red blood cells, i) become mobilized during stress situations into peripheral blood, ii) are enriched in the Sca1+Lin-CD45- cell fraction in mice and the CD133+ Lin-CD45- cell fraction in humans, iii) express markers of pluripotent stem cells (e.g., Oct4, Nanog, and SSEA), and iv) display a distinct morphology characterized by a high nuclear/cytoplasmic ratio and undifferentiated chromatin.

Author(s): 
Ratajczak, Mariusz Z.
Shin, Dong-Myung
Liu, Rui
Mierzejewska, Kasia
Ratajczak, Janina
Kucia, Magda
Zuba-Surma, Ewa K.
Publication Title: 
The American Journal of Pathology

Atherosclerosis, hypertension, obesity, diabetic complications, cancer, benign prostate hyperplasia, Alzheimer and Parkinson diseases, age-related macular degeneration, osteoarthritis, osteoporosis, and seborrheic keratosis are strongly associated with aging, implying a common underlying process. Each disease is treated separately and, in most cases, symptomatically. Suppression of aging itself should delay or treat all age-related diseases, thus increasing healthy life span and maximal longevity. But, is it possible to slow down aging?

Author(s): 
Blagosklonny, Mikhail V.
Publication Title: 
The Journal of Investigative Dermatology

Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply 3'-end sequencing for expression quantification ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin aging (collectively termed "skin aging"), and the impact of broadband light (BBL) treatment.

Author(s): 
Chang, Anne Lynn S.
Bitter, Patrick H.
Qu, Kun
Lin, Meihong
Rapicavoli, Nicole A.
Chang, Howard Y.
Publication Title: 
Current Opinion in Cell Biology

The aging rate of an organism depends on the ratio of tissue degeneration to tissue repair. As a consequence, molecular alterations that tip this balance toward degeneration cause accelerated aging. Conversely, interventions can be pursued to reduce tissue degeneration or to increase tissue repair with the aim of delaying the onset of age-associated manifestations. Recent studies on the biology of stem cells in aging have revealed the influence of systemic factors on their functionality and demonstrated the feasibility of reprogramming aged and progeroid cells.

Author(s): 
Freije, JosÈ M. P.
LÛpez-OtÌn, Carlos
Publication Title: 
Current Opinion in Cell Biology

The progressive increase in the elderly population worldwide has resulted in higher numbers of individuals affected by age-associated diseases, such as neurodegenerative and heart diseases, metabolic impairment, or cancer, with the subsequent burden for national health systems. Therapeutic interventions aimed to increase the quality of life at advanced age are visualized as important demands for the future, both at the level of individuals and society.

Author(s): 
de Jesus, Bruno Bernardes
Blasco, Maria A.

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