Reperfusion Injury

Publication Title: 
Pharmaceutical Biology

CONTEXT: Diabetic nephropathy is one of the important microvascular complications of diabetes; however, the main problem remains is the control of progression of nephropathy in diabetes. Chebulic acid was selected, as tannins from Terminalia chebula are used as antidiabetic, renoprotective, antioxidant, hypotensive and an ?-glucosidase inhibitor. OBJECTIVE: In this study, we evaluated the effect of chebulic acid on ischemia reperfusion induced biochemical alteration in diabetic rats. MATERIALS AND METHODS: Chebulic acid (CA) was isolated from T.

Author(s): 
Silawat, Narendra
Gupta, Vipin Bihari
Publication Title: 
Experimental Gerontology

Dietary or calorie restriction (DR, CR), defined as reduced food intake without malnutrition, imparts many benefits in model organisms. Extended longevity is the most popularized benefit but the least clinically relevant due to the requirement for long-term food restriction. DR also promotes stress resistance and metabolic fitness. Emerging data in experimental models and in humans indicate that these benefits occur rapidly upon initiation of DR, suggesting potential clinical relevance.

Author(s): 
Robertson, Lauren T.
Mitchell, James R.
Publication Title: 
Fundamental & Clinical Pharmacology

Four pre-medication drugs are used to relieve pain, allay anxiety, reduce secretion and enhance hypnosis, were evaluated for their effects on ischemia reperfusion (I/R) injury which is one of the major complications of vascular and transplantation surgery. Right kidney was removed from female rats (210-250 g) 3 weeks before surgical procedure.

Author(s): 
Pazoki-Toroudi, Hamid Reza
Ajami, Marjan
Habibey, Rouhollah
Publication Title: 
Pharmacology, Biochemistry, and Behavior

Free radicals are implicated in causation of cerebral reperfusion injury and chronic cerebral hypoperfusion in rats is associated with functional and histopathological disturbances. Ocimum sanctum (OS), a plant widely used in Ayurveda, has been shown to possess anti-inflammatory, antioxidant and cognition-enhancing properties. In the present study, we investigated the effect of methanolic extract of OS leaves in cerebral reperfusion injury as well as long-term hypoperfusion.

Author(s): 
Yanpallewar, S. U.
Rai, Sunita
Kumar, Mohan
Acharya, S. B.
Publication Title: 
Brain Research Bulletin

Interactions between neurons and astrocytes play a critical role in the central nervous system homeostasis. Cyperus rotundus (family: Cyperaceae), a traditional Indian medicinal herb, used as nervine tonic and nootropic in the Ayurvedic system of medicine. The present study was undertaken to investigate the neuroprotective effect of total oligomeric flavonoids (TOFs), prepared from C. rotundus, in rat model of cerebral ischemia and reperfusion. Male Sprague Dawley rats (290-340g) were subjected to middle cerebral artery occlusion (MCAO) for 2h and reperfusion for 70h.

Author(s): 
Sunil, A. G.
Kesavanarayanan, K. S.
Kalaivani, P.
Sathiya, S.
Ranju, V.
Priya, R. Jyothi
Pramila, B.
Paul, F. D. Solomon
Venkhatesh, J.
Babu, C. Saravana
Publication Title: 
European Journal of Pharmacology

Since flavonoids scavenge reactive oxygen species, they may potentially protect against ischemia/reperfusion injury. This study compared the scavenging capacity of specific flavonoids towards different reactive oxygen species. Whether the differential oxidant scavenging capacity correlated with their protective efficacy in ischemia/reperfusion injury of cardiomyocytes was determined.

Author(s): 
Chang, Wei-Tien
Shao, Zuo-Hui
Yin, Jun-Jie
Mehendale, Sangeeta
Wang, Chong-Zhi
Qin, Yimin
Li, Juan
Chen, Wen-Jone
Chien, Chiang-Ting
Becker, Lance B.
Vanden Hoek, Terry L.
Yuan, Chun-Su
Publication Title: 
Neuroscience

The transcriptional factor Nrf2 has a unique role in various physiological stress conditions, but its contribution to ischemia/reperfusion injury has not been fully explored. Therefore, wildtype (WT) and Nrf2 knockout (Nrf2(-/-)) mice were subjected to 90-min occlusion of the middle cerebral artery (MCA) followed by 24-h reperfusion to elucidate Nrf2 contribution in protecting against ischemia/reperfusion injury. Infarct volume, represented as percent of hemispheric volume, was significantly (P<0.05) larger in Nrf2(-/-) mice than in WT mice (30.8+/-6.1 vs. 17.0+/-5.1%).

Author(s): 
Shah, Z. A.
Li, R.-C.
Thimmulappa, R. K.
Kensler, T. W.
Yamamoto, M.
Biswal, S.
Doré, S.
Publication Title: 
Stroke; a Journal of Cerebral Circulation

BACKGROUND AND PURPOSE: Ginkgo biloba extracts are now prescribed in several countries for their reported health benefits, particularly for medicinal properties in the brain. The standardized Ginkgo extract, EGb761, has been reported to protect neurons against oxidative stress, but the underlying mechanisms are not fully understood. METHODS: To characterize the oral consumption of EGb761 in transient ischemia, we performed the middle cerebral artery occlusion (MCAO) filament model in wild-type and heme oxygenase 1 (HO-1) knockouts.

Author(s): 
Saleem, Sofiyan
Zhuang, Hean
Biswal, Shyam
Christen, Yves
Doré, Sylvain
Publication Title: 
BMC biology

BACKGROUND: We have recently shown that delta-opioid receptors (DORs) play an important role in neuroprotection from hypoxic injury via the regulation of extracellular signaling-regulated kinase (ERK) and cytochrome c release. Since ERK and cytochrome c are differentially involved in caspase signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion, we considered if DOR activation protects the ischemic brain by attenuating oxidative injury.

Author(s): 
Yang, Yilin
Xia, Xiwei
Zhang, Yi
Wang, Qiang
Li, Lu
Luo, Guanghua
Xia, Ying
Publication Title: 
Journal of Biomedical Science

Perinatal taurine depletion and high sugar diets blunted baroreflex function and heightens sympathetic nerve activity in adult rats. Cardiac ischemia/reperfusion also produces these disorders and taurine treatment appears to improve these effects. This study tests the hypothesis that perinatal taurine exposure predisposes recovery from reperfusion injury in rats on either a basal or high sugar diet.

Author(s): 
Kulthinee, Supaporn
Wyss, J. Michael
Jirakulsomchok, Dusit
Roysommuti, Sanya

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