Response Elements

Publication Title: 
Journal of Neurochemistry

The human tyrosine hydroxylase (hTH) gene has a 42†bp evolutionarily conserved region designated (CR) II at -7.24†kb, which bears 93% homology to the region we earlier identified as containing the glucocorticoid response element, a 7†bp activator protein-1 (AP-1)-like motif in the rat TH gene. We cloned this hTH-CRII region upstream of minimal basal hTH promoter in luciferase (Luc) reporter vector, and tested glucocorticoid responsiveness in human cell lines.

Author(s): 
Sheela Rani, C. S.
Soto-Pina, Alexandra
Iacovitti, Lorraine
Strong, Randy
Publication Title: 
Genome Biology

BACKGROUND: Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. RESULTS: We examined the effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock. After controlling for blood cell-type composition and lifestyle parameters, cumulative lifetime stress, but not childhood maltreatment or current stress alone, predicted accelerated epigenetic aging in an urban, African American cohort (n?=?392).

Author(s): 
Zannas, Anthony S.
Arloth, Janine
Carrillo-Roa, Tania
Iurato, Stella
Rˆh, Simone
Ressler, Kerry J.
Nemeroff, Charles B.
Smith, Alicia K.
Bradley, Bekh
Heim, Christine
Menke, Andreas
Lange, Jennifer F.
Br¸ckl, Tanja
Ising, Marcus
Wray, Naomi R.
Erhardt, Angelika
Binder, Elisabeth B.
Mehta, Divya
Publication Title: 
PloS One

The present day lifestyle heavily depends on industrial chemicals in the form of agriculture, cosmetics, textiles and medical products. Since the toxicity of the industrial chemicals has been a concern to human health, the need for alternative non-toxic natural products or adjuvants that serve as antidotes are in high demand. We have investigated the effects of Ayurvedic herb Ashwagandha (Withania somnifera) leaf extract on methoxyacetic acid (MAA) induced toxicity.

Author(s): 
Priyandoko, Didik
Ishii, Tetsuro
Kaul, Sunil C.
Wadhwa, Renu
Publication Title: 
International Journal of Oncology

We previously established a bioassay method to screen for compounds that activate the promoter activity of p21(WAF1/CIP1), a potent inhibitor of cyclin-dependent kinases, in a p53-independent manner. As an activator of p21(WAF1/CIP1) promoter activity, we isolated cryptolepine (CLP: 5-methyl indolo (2,3b)-quiniine), an indoloquinoline alkaloid, from the traditional Ayurvedic medicinal plant Sida cordifolia. We show here that CLP induces the expression of p21(WAF1/CIP1) with growth arrest in p53-mutated human osteosarcoma MG63 cells.

Author(s): 
Matsui, Taka-aki
Sowa, Yoshihiro
Murata, Hiroaki
Takagi, Koichi
Nakanishi, Ryoko
Aoki, Shunji
Yoshikawa, Masayuki
Kobayashi, Motomasa
Sakabe, Tomoya
Kubo, Toshikazu
Sakai, Toshiyuki
Publication Title: 
PloS One

The present day lifestyle heavily depends on industrial chemicals in the form of agriculture, cosmetics, textiles and medical products. Since the toxicity of the industrial chemicals has been a concern to human health, the need for alternative non-toxic natural products or adjuvants that serve as antidotes are in high demand. We have investigated the effects of Ayurvedic herb Ashwagandha (Withania somnifera) leaf extract on methoxyacetic acid (MAA) induced toxicity.

Author(s): 
Priyandoko, Didik
Ishii, Tetsuro
Kaul, Sunil C.
Wadhwa, Renu
Publication Title: 
Journal of Agricultural and Food Chemistry

Because the prevailing form of hormone replacement therapy is associated with the development of cancer in breast and endometrial tissues, alternatives are needed for the management of menopausal symptoms. Formulations of Trifolium pratense L. (red clover) are being used to alleviate menopause-associated hot flashes but have shown mixed results in clinical trials. The strobiles of Humulus lupulusL.

Author(s): 
Overk, Cassia R.
Yao, Ping
Chadwick, Lucas R.
Nikolic, Dejan
Sun, Yongkai
Cuendet, Muriel A.
Deng, Yunfan
Hedayat, A. S.
Pauli, Guido F.
Farnsworth, Norman R.
van Breemen, Richard B.
Bolton, Judy L.
Publication Title: 
Circulation Research

The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that is highly expressed in liver, kidney, adrenals, and intestine. FXR may play an important role in the pathogenesis of cardiovascular diseases via regulating the metabolism and transport of cholesterol. In this study, we report that FXR is also expressed in rat pulmonary artery endothelial cells (EC), a "nonclassical" bile acid target tissue.

Author(s): 
He, Fengtian
Li, Jiang
Mu, Ying
Kuruba, Ramalinga
Ma, Zheng
Wilson, Annette
Alber, Sean
Jiang, Yu
Stevens, Troy
Watkins, Simon
Pitt, Bruce
Xie, Wen
Li, Song
Publication Title: 
The Biochemical Journal

CYP3A4 (cytochrome P450 3A4) is involved in the metabolism of more than 50% of drugs and other xenobiotics. The expression of CYP3A4 is induced by many structurally dissimilar compounds. The PXR (pregnane X receptor) is recognized as a key regulator for the induction, and the PXR-directed transactivation of the CYP3A4 gene is achieved through a co-ordinated mechanism of the distal module with the proximal promoter. Recently, a far module was found to support constitutive expression of CYP3A4.

Author(s): 
Liu, Fu-Jun
Song, Xiulong
Yang, Dongfang
Deng, Ruitang
Yan, Bingfang
Publication Title: 
Combinatorial Chemistry & High Throughput Screening

Symptoms associated with menopause can greatly affect the quality of life for women. Botanical dietary supplements have been viewed by the public as safe and effective despite a lack of evidence indicating a urgent necessity to standardize these supplements chemically and biologically.

Author(s): 
Overk, Cassia R.
Yao, Ping
Chen, Shaonong
Deng, Shixing
Imai, Ayano
Main, Matthew
Schinkovitz, Andreas
Farnsworth, Norman R.
Pauli, Guido F.
Bolton, Judy L.
Publication Title: 
Stroke; a Journal of Cerebral Circulation

BACKGROUND AND PURPOSE: Ginkgo biloba extracts are now prescribed in several countries for their reported health benefits, particularly for medicinal properties in the brain. The standardized Ginkgo extract, EGb761, has been reported to protect neurons against oxidative stress, but the underlying mechanisms are not fully understood. METHODS: To characterize the oral consumption of EGb761 in transient ischemia, we performed the middle cerebral artery occlusion (MCAO) filament model in wild-type and heme oxygenase 1 (HO-1) knockouts.

Author(s): 
Saleem, Sofiyan
Zhuang, Hean
Biswal, Shyam
Christen, Yves
Doré, Sylvain

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