Ribonucleotide Reductases

Publication Title: 
Age (Dordrecht, Netherlands)

Dietary restriction (DR) increases lifespan in a range of evolutionarily distinct species. The polyphenol resveratrol may be a dietary mimetic of some effects of DR. The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing.

Author(s): 
Wakeling, Luisa A.
Ions, Laura J.
Ford, Dianne
Publication Title: 
Age (Dordrecht, Netherlands)

Dietary restriction (DR) increases lifespan in a range of evolutionarily distinct species. The polyphenol resveratrol may be a dietary mimetic of some effects of DR. The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing.

Author(s): 
Wakeling, Luisa A.
Ions, Laura J.
Ford, Dianne
Publication Title: 
Age (Dordrecht, Netherlands)

Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation. Resveratrol increases metabolic rate, insulin sensitivity, mitochondrial biogenesis and physical endurance, and reduces fat accumulation in mice. In addition, resveratrol may be a powerful agent to prevent age-associated neurodegeneration and to improve cognitive deficits in Alzheimer's disease (AD). Moreover, different findings support the view that longevity in mice could be promoted by CR.

Author(s): 
Porquet, David
Casades˙s, Gemma
Bayod, Sergi
Vicente, Alberto
Canudas, Anna M.
Vilaplana, Jordi
PelegrÌ, Carme
Sanfeliu, Coral
Camins, Antoni
Pall‡s, MercË
del Valle, Jaume
Publication Title: 
Cell Cycle (Georgetown, Tex.)

In many organisms, attenuation of growth signaling by caloric restriction or mutational inactivation of growth signaling pathways extends lifespan and protects against cancer and other age-related diseases. The focus of many efforts to understand these effects has been on the induction of oxidative stress defenses that inhibit cellular senescence and cell death. Here we show that in the model organism S.

Author(s): 
Weinberger, Martin
Sampaio-Marques, Belém
Ludovico, Paula
Burhans, William C.
Publication Title: 
Cell Cycle (Georgetown, Tex.)

In many organisms, attenuation of growth signaling by caloric restriction or mutational inactivation of growth signaling pathways extends lifespan and protects against cancer and other age-related diseases. The focus of many efforts to understand these effects has been on the induction of oxidative stress defenses that inhibit cellular senescence and cell death. Here we show that in the model organism S.

Author(s): 
Weinberger, Martin
Sampaio-Marques, Belém
Ludovico, Paula
Burhans, William C.
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