Publication Title: 
PloS One

BACKGROUND: Bias in randomized controlled trials (RCTs) of complementary therapy interventions seems to be associated with specific factors and to potentially distort the studies' conclusions. This systematic review assessed associated factors of risk of bias and consequences for the studies' conclusions in RCTs of yoga as one of the most commonly used complementary therapies. METHODS: Medline/PubMed, Scopus, IndMED and the Cochrane Library were searched through February 2014 for yoga RCTs.

Cramer, Holger
Langhorst, Jost
Dobos, Gustav
Lauche, Romy
Publication Title: 
Nutritional Neuroscience

BACKGROUND: Major depressive disorder is a common, chronic condition that imposes a substantial burden of disability globally. As current treatments are estimated to address only one-third of the disease burden of depressive disorders, there is a need for new approaches to prevent depression or to delay its progression. While in its early stages, converging evidence from laboratory, population research, and clinical trials now suggests that dietary patterns and specific dietary factors may influence the risk for depression.

Opie, R. S.
Itsiopoulos, C.
Parletta, N.
Sanchez-Villegas, A.
Akbaraly, T. N.
Ruusunen, A.
Jacka, F. N.
Publication Title: 
Journal of Cardiology

BACKGROUND: Syncope is one of the most common reasons for emergency department and urgent care clinic visits. The management of syncope continues to be a challenging problem for front-line providers inasmuch as there are a multitude of possible causes for syncope ranging from relatively benign conditions to potentially life-threatening ones. In any event, it is important to identify those syncope patients who are at immediate risk of life-threatening events; these individuals require prompt hospitalization and thorough evaluation.

Puppala, Venkata Krishna
Dickinson, Oana
Benditt, David G.
Publication Title: 
Complementary Therapies in Medicine

BACKGROUND: To date, our programme of systematic reviews has assessed randomised controlled trials (RCTs) of individualised homeopathy separately for risk of bias (RoB) and for model validity of homeopathic treatment (MVHT). OBJECTIVES: The purpose of the present paper was to bring together our published RoB and MVHT findings and, using an approach based on GRADE methods, to merge the quality appraisals of these same RCTs, examining the impact on meta-analysis results. DESIGN: Systematic review with meta-analysis.

Mathie, Robert T.
Van Wassenhoven, Michel
Jacobs, Jennifer
Oberbaum, Menachem
Frye, Joyce
Manchanda, Raj K.
Roniger, Helmut
Dantas, Flávio
Legg, Lynn A.
Clausen, Jürgen
Moss, Sian
Davidson, Jonathan R. T.
Lloyd, Suzanne M.
Ford, Ian
Fisher, Peter
Publication Title: 
PloS One

OBJECTIVE: The safety of bee venom as a therapeutic compound has been extensively studied, resulting in the identification of potential adverse events, which range from trivial skin reactions that usually resolve over several days to life-threating severe immunological responses such as anaphylaxis. In this systematic review, we provide a summary of the types and prevalence of adverse events associated with bee venom therapy. METHODS: We searched the literature using 12 databases from their inception to June 2014, without language restrictions.

Park, Jeong Hwan
Yim, Bo Kyung
Lee, Jun-Hwan
Lee, Sanghun
Kim, Tae-Hun
Publication Title: 

CONTEXT: Lead, mercury, and arsenic intoxication have been associated with the use of Ayurvedic herbal medicine product (HMPs). OBJECTIVES: To determine the prevalence and concentration of heavy metals in Ayurvedic HMPs manufactured in South Asia and sold in Boston-area stores and to compare estimated daily metal ingestion with regulatory standards.

Saper, Robert B.
Kales, Stefanos N.
Paquin, Janet
Burns, Michael J.
Eisenberg, David M.
Davis, Roger B.
Phillips, Russell S.
Publication Title: 

OBJECTIVE: To examine the relative risk and population attributable risk (PAR) of death with dementia of varying type and severity and other risk factors in a population of exceptional longevity. METHODS: Deaths were monitored over 5 years using vital statistics records and newspaper obituaries in 355 individuals with prevalent dementia and 4,328 without in Cache County, UT. Mean age was 83.3 (SD 7.0) years with dementia and 73.7 (SD 6.8) years without. History of coronary artery disease, hypertension, diabetes, and other life-shortening illness was ascertained from interviews.

Tschanz, J. T.
Corcoran, C.
Skoog, I.
Khachaturian, A. S.
Herrick, J.
Hayden, K. M.
Welsh-Bohmer, K. A.
Calvert, T.
Norton, M. C.
Zandi, P.
Breitner, J. C. S.
Cache County Study Group
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To assess the cause of death for centenarians' offspring and controls. DESIGN: Cross-sectional study. SETTING: Community-based, nationwide sample. PARTICIPANTS: Family pedigree information was collected on 295 offspring of centenarians (from 106 families with a parent already enrolled in the nationwide New England Centenarian Study) and on 276 controls (from 82 control families) from 1997 to 2000. Controls were individuals whose parents were born in the same year as the centenarians but at least one of whom died at the average life expectancy.

Terry, Dellara F.
Wilcox, Marsha A.
McCormick, Maegan A.
Pennington, JaeMi Y.
Schoenhofen, Emily A.
Andersen, Stacy L.
Perls, Thomas T.
Publication Title: 
JAMA neurology

IMPORTANCE: Family studies of centenarians and long-lived persons have found substantial familial aggregation of survival to extreme ages; however, the extent to which such familial longevity is characterized by cognitively intact survival is not established. OBJECTIVE: To determine whether families with exceptional longevity are protected against cognitive impairment consistent with Alzheimer disease. DESIGN: Cross-sectional analysis. SETTING: Multisite study in New York, Massachusetts, Pennsylvania, and Denmark.

Cosentino, Stephanie
Schupf, Nicole
Christensen, Kaare
Andersen, Stacy L.
Newman, Anne
Mayeux, Richard
Publication Title: 
Dental Clinics of North America

In the late 1960's, preventive health care began to gain in popularity in the United States and the movement carried over into the 1970's. During this time, sizable decreases in deaths from heart disease, strokes, and accidents have been noted. As a result, the lowest death rate in the history of this country (8.9 per 1000) occurred in both 1975 and 1976. Since 1970, an increase in longevity has been documented and it can be said that Americans are living longer--not just longer but hopefully better!

Cooper, K. H.
Christen, A. G.


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