Publication Title: 
PloS One

The number of fully active antibiotic options that treat nosocomial infections due to multidrug-resistant Acinetobacter baumannii (A. baumannii) is extremely limited. Magnolia officinalis, Mahonia bealei, Rabdosia rubescens, Rosa rugosa, Rubus chingii, Scutellaria baicalensis, and Terminalia chebula plant extracts were previously shown to have growth inhibitory activity against a multidrug-resistant clinical strain of A. baumannii.

Miyasaki, Yoko
Rabenstein, John D.
Rhea, Joshua
Crouch, Marie-Laure
Mocek, Ulla M.
Kittell, Patricia Emmett
Morgan, Margie A.
Nichols, Wesley Stephen
Van Benschoten, M. M.
Hardy, William David
Liu, George Y.
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

Drug discovery from complex mixture like Chinese herbs is a challenge and extensive false positives make the obtainment of specific bioactive compounds difficult. In the present study, a novel sample preparation method was proposed to rapidly reveal the specific bioactive compounds from complex mixtures using ?-glucosidase as a case. Firstly, aqueous and methanol extracts of 500 traditional Chinese medicines were carried out with the aim of finding new sources of ?-glucosidase inhibitors.

Li, D. Q.
Zhao, J.
Xie, J.
Li, S. P.
Publication Title: 
Indian Journal of Experimental Biology

Rosa damascena has been found to act on central nervous system including brain. It inhibits the reactivity of the hypothalamous and pituitary systems in rat. In traditional medicine hypnotic effect of Rose is also suggested. In the present study hypnotic effect of ethanolic, aqueous and chloroformic extracts of R. damascena was investigated in mice. Hypnotic method was based on potentiation of pentobarbital induced sleeping time by extracts. Three doses of extracts (100, 500 and 1000 mg/kg) were injected i.p.

Rakhshandah, H.
Hosseini, M.
Publication Title: 
Natural Product Communications

One increasingly popular type of alternative therapy is aromatherapy, but scientific validation in this field is still rare. The aim of this study was to investigate the effect of rose oil (Rosa damascena Mill, Rosaceae) on human autonomic parameters and emotional responses in healthy subjects after transdermal absorption. In order to exclude any olfactory stimulation the inhalation of the fragrances was prevented by breathing masks. Forty healthy volunteers participated in the experiments. Five autonomic parameters, i.e.

Hongratanaworakit, Tapanee
Publication Title: 
Die Pharmazie

Essential oils are ingredients of cosmetic and health care products as well as massage oil used in aromatherapy. There is no doubt that essential oils and their components are able to permeate human skin. But information is rare dealing with percutanous absorption of essential oils in more detail. In this paper we investigated the in vitro skin permeation of monoterpenes and phenylpropanoids applied in pure rose oil and in form of neat single substances. We found that the application form had an exceeding influence on the skin permeation behaviour of the compounds.

Schmitt, S.
Schaefer, U.
Sporer, F.
Reichling, J.
Publication Title: 
Forschende Komplement�rmedizin (2006)

BACKGROUND: Rose oil is the essential oil extracted from the petals of the damask rose. It is an ingredient of cosmetic as well as health care products and it is used in folk medicine and in aromatherapy. It is well known that essential oils are able to permeate the skin whereas the lipophilic properties of the compounds as well as the application site have an influence on their permeation behaviour. In this paper, we investigated the influence of the application site on the permeation of rose oil.

Schmitt, Sonja
Sch�fer, Ulrich F.
D�bler, Leonhard
Reichling, J�rgen
Publication Title: 
Complementary Therapies in Clinical Practice

OBJECTIVES: The aim of this study was to determine if aromatherapy improves anxiety and/or depression in the high risk postpartum woman and to provide a complementary therapy tool for healthcare practitioners. DESIGN: The pilot study was observational with repeated measures. SETTING: Private consultation room in a Women's center of a large Indianapolis hospital. SUBJECTS: 28 women, 0-18 months postpartum. INTERVENTIONS: The treatment groups were randomized to either the inhalation group or the aromatherapy hand m'technique.

Conrad, Pam
Adams, Cindy
Publication Title: 
Complementary Therapies in Clinical Practice

OBJECTIVE: Sleep disorders are common among patients hospitalized in coronary care unit (CCU). This study aimed to investigate the effect of Rosa damascene aromatherapy on sleep quality of patients hospitalized in CCU. METHODS: In this randomized controlled trial, 60 patients who met the inclusion criteria were conveniently sampled and randomly allocated to the experimental and control groups. Patients in the control group received routine care. In the experimental group, patients received routine care and Rosa damascene aromatherapy for three subsequent nights.

Hajibagheri, Ali
Babaii, Atye
Adib-Hajbaghery, Mohsen
Publication Title: 

Rosa damascena, or Damask rose, is a rose hybrid commonly harvested for rose oil used in perfumery and for rose water used to flavor food. The petal extract of R. damascena was recently found to decrease Drosophila melanogaster mortality without impairing reproductive fitness or metabolic rate. Here, we report that R. damascena extended both mean and maximum lifespan of the fly. The extract also protected against oxidative stress in flies, predominantly in females.

Schriner, Samuel E.
Katoozi, Niki S.
Pham, Kevin Q.
Gazarian, Maral
Zarban, Asghar
Jafari, Mahtab
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

The aim of this study was to investigate the metabolic effects of a dietary supplement of powdered rose hip to C57BL/6J mice fed a high-fat diet (HFD). Two different study protocols were used; rose hip was fed together with HFD to lean mice for 20 wk (prevention study) and to obese mice for 10 wk (intervention study). Parameters related to obesity and glucose tolerance were monitored, and livers were examined for lipids and expression of genes and proteins related to lipid metabolism and gluconeogenesis.

Andersson, Ulrika
Henriksson, Emma
Ström, Kristoffer
Alenfall, Jan
Göransson, Olga
Holm, Cecilia


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