Rotarod Performance Test

Publication Title: 
Physiology & Behavior

Ketogenic diets are high in fat and low in carbohydrates, and have long been used as an anticonvulsant therapy for drug-intractable and pediatric epilepsy. Additionally, ketogenic diets have been shown to provide neuroprotective effects against acute and chronic brain injury, including beneficial effects in various rodent models of neurodegeneration. Huntington's disease is a progressive neurodegenerative disease characterized by neurological, behavioral and metabolic dysfunction, and ketogenic diets have been shown to increase energy molecules and mitochondrial function.

Author(s): 
Ruskin, David N.
Ross, Jessica L.
Kawamura, Masahito
Ruiz, Tiffany L.
Geiger, Jonathan D.
Masino, Susan A.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

Target of rapamycin inhibition by rapamycin feeding has previously been shown to extend life in genetically heterogeneous mice. To examine whether it similarly affected mouse health, we fed encapsulated rapamycin or a control diet to C57BL/6Nia mice of both sexes starting at 19 months of age. We performed a range of health assessments 6 and 12 months later. Rapamycin feeding significantly reduced mTOR activity in most but not all tissues.

Author(s): 
Zhang, Yiqiang
Bokov, Alex
Gelfond, John
Soto, Vanessa
Ikeno, Yuji
Hubbard, Gene
Diaz, Vivian
Sloane, Lauren
Maslin, Keith
Treaster, Stephen
RÈndon, Samantha
Van Remmen, Holly
Ward, Walter
Javors, Martin
Richardson, Arlan
Austad, Steven N.
Fischer, Kathleen
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Recent studies have identified impairments in neural induction and in striatal and cortical neurogenesis in Huntington's disease (HD) knock-in mouse models and associated embryonic stem cell lines. However, the potential role of these developmental alterations for HD pathogenesis and progression is currently unknown. To address this issue, we used BACHD:CAG-Cre(ERT2) mice, which carry mutant huntingtin (mHtt) modified to harbor a floxed exon 1 containing the pathogenic polyglutamine expansion (Q97).

Author(s): 
Molero, Aldrin E.
Arteaga-Bracho, Eduardo E.
Chen, Christopher H.
Gulinello, Maria
Winchester, Michael L.
Pichamoorthy, Nandini
Gokhan, Solen
Khodakhah, Kamran
Mehler, Mark F.
Publication Title: 
Brain Research

The present study investigated whether the differential sensitivity of selectively bred gamma-hydroxybutyric acid (GHB)-sensitive (GHB-S) and GHB-resistant (GHB-R) rats to GHB- and baclofen-induced sedation/hypnosis generalized to the motor incoordinating effect of the two drugs. To this aim, GHB-S and GHB-R rats were tested on a Rota-Rod after the acute administration of GHB (100-500 mg/kg, i.p.) and baclofen (1.25-5 mg/kg, i.p.).

Author(s): 
Lobina, Carla
Colombo, Giancarlo
Gessa, Gian Luigi
Carai, Mauro A. M.
Publication Title: 
Pharmaceutical Biology

CONTEXT: Fruits of Ternstroemia sylvatica Schltdl. and Cham. (Theaceae) are used in Mexican traditional medicine to alleviate anxiety, sleep disorders and seizures; however, the active principles have not been identified. OBJECTIVE: To identify the neuroactive principles of T. sylvatica fruits using neuropharmacological tests on mice. MATERIALS AND METHODS: The methanol and aqueous extracts of pericarp or seeds of T. sylvatica fruits were intraperitoneally administered (1-562?mg/kg, single doses) to mice.

Author(s): 
Balderas-López, José Luis
Alfaro-Romero, Alejandro
Monroy, Amor
López-Villafranco, Ma Edith
Rivero-Cruz, José Fausto
Navarrete, Andrés
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: The oleo gum resin of Gardenia lucida is commonly employed in traditional medicine to treat multiple ailments, including epilepsy and mania. The essential oil isolated from it was screened for CNS activities to check if it is responsible for the claims made regarding the traditional use of the oleo gum resin. MATERIALS AND METHODS: The hypnotic and anticonvulsant activity was assessed by pentobarbitone induced hypnosis and convulsant models-Maximum electroshock (MES) and Pentylene tetrazole (PTZ) respectively.

Author(s): 
Shareef, Mohammad Zubair
Yellu, Narsimha Reddy
Achanta, Venkata Narsimha Appa Rao
Publication Title: 
The European Journal of Neuroscience

How external stimuli prevent the onset of sleep has been little studied. This is usually considered to be a non-specific type of phenomenon. However, the hypnotic drug dexmedetomidine, an agonist at ?2 adrenergic receptors, has unusual properties that make it useful for investigating this question. Dexmedetomidine is considered to produce an 'arousable' sleep-like state, so that patients or animals given dexmedetomidine become alert following modest stimulation.

Author(s): 
Gelegen, Cigdem
Gent, Thomas C.
Ferretti, Valentina
Zhang, Zhe
Yustos, Raquel
Lan, Fei
Yang, Qianzi
Overington, Dorothy W. U.
Vyssotski, Alexei L.
van Lith, Hein A.
Wisden, William
Franks, Nicholas P.
Publication Title: 
Biochemical and Biophysical Research Communications

Tob (transducer of ErbB-2) is a negative cell cycle regulator with anti-proliferative activity in peripheral tissues. Our previous study identified Tob as a protein involved in hippocampus-dependent memory consolidation (M.L. Jin, X.M. Wang, Y.Y. Tu, X.H. Zhang, X. Gao, N. Guo, Z.Q. Xie, G.P. Zhao, N.H. Jing, B.M. Li, Y.Yu, The negative cell cycle regulator, Tob (Transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory, Neuroscience 131 (2005) 647-659).

Author(s): 
Wang, Xin-Ming
Gao, Xiang
Zhang, Xue-Han
Tu, Yan-yang
Jin, Mei-Lei
Zhao, Guo-Ping
Yu, Lei
Jing, Nai-He
Li, Bao-Ming
Publication Title: 
Neurochemistry International

Lanthionines are novel neurotrophic and neuroprotective small molecules that show promise for the treatment of neurodegenerative diseases. In particular, a recently developed, cell permeable lanthionine derivative known as LKE (lanthionine ketimine 5-ethyl ester) promotes neurite growth at low nanomolar concentrations. LKE also has neuroprotective, anti-apoptotic, and anti-inflammatory properties. Its therapeutic potential in cerebral ischemia and its mechanisms of neurotrophic action remain to be fully elucidated.

Author(s): 
Nada, Shadia E.
Tulsulkar, Jatin
Raghavan, Aparna
Hensley, Kenneth
Shah, Zahoor A.
Publication Title: 
Biological & Pharmaceutical Bulletin

The acetate (FA), hexanic (FH), hydroalcoholic (FHA) and precipitated hydroalcoholic (FHAppt) fractions from the root of Petiveria alliacea L. were evaluated for antinociceptive effect using the abdominal constriction induced by acetic acid, hot-plate, formalin tests. The open field and rota rod tests were used to evaluate psychomotor function and myorelaxant activity. The fractions were administered intraperitoneally in mice at doses of 100 and 200 mg/kg. Inhibitions of abdominal constrictions were observed with all doses of the fractions, as compared to control.

Author(s): 
Gomes, Patrícia Bezerra
Oliveira, Maria Mirele da Silva
Nogueira, Carlos Renato Alves
Noronha, Emmanuelle Coelho
Carneiro, Lyvia Maria Vasconcelos
Bezerra, José Noberto Sousa
Neto, Manoel Andrade
Vasconcelos, Silvania Maria Mendes
Fonteles, Marta Maria França
Viana, Glauce Socorro Barros
de Sousa, Francisca Clea Florenço

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