S-Adenosylmethionine

Publication Title: 
Journal of Affective Disorders

BACKGROUND: In 2001, the Canadian Psychiatric Association and the Canadian Network for Mood and Anxiety Treatments (CANMAT) partnered to produce evidence-based clinical guidelines for the treatment of depressive disorders. A revision of these guidelines was undertaken by CANMAT in 2008-2009 to reflect advances in the field. There is widespread interest in complementary and alternative medicine (CAM) therapies in the treatment of major depressive disorder (MDD). METHODS: The CANMAT guidelines are based on a question-answer format to enhance accessibility to clinicians.

Author(s): 
Ravindran, Arun V.
Lam, Raymond W.
Filteau, Marie J.
Lespérance, François
Kennedy, Sidney H.
Parikh, Sagar V.
Patten, Scott B.
Canadian Network for Mood and Anxiety Treatments (CANMAT)
Publication Title: 
Journal of Affective Disorders

BACKGROUND: Depressed and anxious patients often combine complementary and alternative medicine (CAM) therapies with conventional pharmacotherapy to self-treat symptoms. The benefits and risks of such combination strategies have not been fully evaluated. This paper evaluates the risk-benefit profile of CAM augmentation to antidepressants in affective conditions. METHODS: PubMed was searched for all available clinical reports published in English up to December 2012. Data were evaluated based on graded levels of evidence for efficacy and safety.

Author(s): 
Ravindran, Arun V.
da Silva, Tricia L.
Publication Title: 
Rheumatology (Oxford, England)

OBJECTIVE: To critically evaluate the evidence regarding complementary and alternative medicines (CAMs) taken orally or applied topically for the treatment of FM. METHODS: Randomized controlled trials of FM using CAMs, in comparison with other treatments or placebo, published in English up to March 2009, were eligible for inclusion. They were identified using systematic searches of bibliographic databases and manual searching of reference lists.

Author(s): 
De Silva, Vijitha
El-Metwally, Ashraf
Ernst, Edzard
Lewith, George
Macfarlane, Gary J.
Arthritis Research Campaign working group on complementary and alternative medicines
Publication Title: 
Biochimica Et Biophysica Acta

This review describes our current understanding of the "traffic lights" that regulate sulfur flow through the methionine bionetwork in liver, which supplies two major homeostatic systems governing cellular methylation and antioxidant potential. Theoretical concepts derived from mathematical modeling of this metabolic nexus provide insights into the properties of this system, some of which seem to be paradoxical at first glance. Cellular needs supported by this network are met by use of parallel metabolic tracks that are differentially controlled by intermediates in the pathway.

Author(s): 
Martinov, M. V.
Vitvitsky, V. M.
Banerjee, R.
Ataullakhanov, F. I.
Publication Title: 
Psychiatria Polska

S-adenosyl L-methionine (SAMe) is the natural, universal methyl group donor, participating in transmethylation reactions, known and commonly used as a dietary supplement since 1952. It plays an important role in the synthesis of neuromediators and melatonin and mechanisms of epigenetic regulation. The aim of this article is to review the literature about possibilities of SAMe application in the therapy of CNS diseases: depression, dementia syndromes, schizophrenia and somatic disorders.

Author(s): 
Krzystanek, Marek
Pa?asz, Artur
Krzystanek, Ewa
Krupka-Matuszczyk, Irea
Wiaderkiewicz, Ryszard
Skowronek, Rafa?
Publication Title: 
Current Opinion in Psychiatry

PURPOSE OF REVIEW: Nutrition exerts a pervasive impact on normal and pathological conditions of the nervous system. One critical pathway is the methionine cycle, in which folate and B12 convert homocysteine to methionine, which is in turn converted to S-adenosyl methionine (SAM; the major methyl donor). As a consequence of methylation, however, SAM is converted to the neurotoxin homocysteine and must be excreted or drawn back into the methionine cycle, which requires additional folate and B12.

Author(s): 
Shea, Thomas B.
Rogers, Eugene
Publication Title: 
Progress in Molecular Biology and Translational Science

Based on postmortem brain studies, our overarching epigenetic hypothesis is that chronic schizophrenia (SZ) is a psychopathological condition involving dysregulation of the dynamic equilibrium among DNA methylation/demethylation network components and the expression of SZ target genes, including GABAergic and glutamatergic genes. SZ has a natural course, starting with a prodromal phase, a first episode that occurs in adolescents or in young adults, and later deterioration over the adult years.

Author(s): 
Guidotti, Alessandro
Dong, Erbo
Tueting, Patricia
Grayson, Dennis R.
Publication Title: 
Journal of Affective Disorders

A growing number of patients with mood disorders are using complementary and alternative medicine (CAM) interventions. In this paper, we review the published scientific evidence on the benefits and risks of CAM for the treatment of patients with bipolar disorder. Since very few studies of CAM have involved patients with bipolar disorder, most available evidence is derived from trials conducted in patients with major depressive disorder. The use of omega-3 fatty acids has been studied in two controlled studies in bipolar disorder while St.

Author(s): 
Andreescu, Carmen
Mulsant, Benoit H.
Emanuel, James E.
Publication Title: 
Journal of Affective Disorders

BACKGROUND: In 2001, the Canadian Psychiatric Association and the Canadian Network for Mood and Anxiety Treatments (CANMAT) partnered to produce evidence-based clinical guidelines for the treatment of depressive disorders. A revision of these guidelines was undertaken by CANMAT in 2008-2009 to reflect advances in the field. There is widespread interest in complementary and alternative medicine (CAM) therapies in the treatment of major depressive disorder (MDD). METHODS: The CANMAT guidelines are based on a question-answer format to enhance accessibility to clinicians.

Author(s): 
Ravindran, Arun V.
Lam, Raymond W.
Filteau, Marie J.
Lespérance, François
Kennedy, Sidney H.
Parikh, Sagar V.
Patten, Scott B.
Canadian Network for Mood and Anxiety Treatments (CANMAT)
Publication Title: 
Journal of Affective Disorders

BACKGROUND: Depressed and anxious patients often combine complementary and alternative medicine (CAM) therapies with conventional pharmacotherapy to self-treat symptoms. The benefits and risks of such combination strategies have not been fully evaluated. This paper evaluates the risk-benefit profile of CAM augmentation to antidepressants in affective conditions. METHODS: PubMed was searched for all available clinical reports published in English up to December 2012. Data were evaluated based on graded levels of evidence for efficacy and safety.

Author(s): 
Ravindran, Arun V.
da Silva, Tricia L.

Pages

Subscribe to RSS - S-Adenosylmethionine