Salacia

Publication Title: 
Bioscience, Biotechnology, and Biochemistry

Kothala himbutu is a traditional Ayurvedic medicinal plant used to treat diabetes. We aimed to evaluate the safety of an aqueous extract of Kothala himbutu stem (KTE) in normal mice. The mice were divided into two groups: one was administered KTE and the other distilled water for 3 weeks. During the test period, the groups showed no significant differences in body weight gain or plasma parameters, such as fasting blood glucose level, oral glucose tolerance test, or aspartate transaminase (AST) or alanine transaminase (ALT) activity.

Author(s): 
Im, Ryanghyok
Mano, Hiroshi
Nakatani, Sachie
Shimizu, Jun
Wada, Masahiro
Publication Title: 
BMC research notes

BACKGROUND: Salacia reticulata (SR) is a plant native to Sri Lanka. In ayurvedic medicine, SR bark preparations, taken orally, are considered effective in the treatment of rheumatism and diabetes. We investigated the ability of SR leaves (SRL) to inhibit in vitro the interleukin-1β (IL-1β)-activated proliferation of synoviocyte-like cells derived from rheumatoid arthritis model mice. FINDINGS: Inflammatory synovial tissues were harvested from type II collagen antibody-induced arthritic mice. From these tissues, a synoviocyte-like cell line was established and named MTS-C H7.

Author(s): 
Sekiguchi, Yuusuke
Mano, Hiroshi
Nakatani, Sachie
Shimizu, Jun
Kobata, Kenji
Wada, Masahiro
Publication Title: 
Toxicology and Applied Pharmacology

Salacia oblonga (SO) root is an Ayurvedic medicine with anti-diabetic and anti-obese properties. Peroxisome proliferator-activated receptor (PPAR)-alpha, a nuclear receptor, plays an important role in maintaining the homeostasis of lipid metabolism.

Author(s): 
Huang, Tom Hsun-Wei
Peng, Gang
Li, George Qian
Yamahara, Johji
Roufogalis, Basil D.
Li, Yuhao
Publication Title: 
Toxicology and Applied Pharmacology

Excess cardiac triglyceride accumulation in diabetes and obesity induces lipotoxicity, which predisposes the myocytes to death. On the other hand, increased cardiac fatty acid (FA) oxidation plays a role in the development of myocardial dysfunction in diabetes. PPAR-alpha plays an important role in maintaining homeostasis of lipid metabolism.

Author(s): 
Huang, Tom Hsun-Wei
Yang, Qinglin
Harada, Masaki
Uberai, Jasna
Radford, Jane
Li, George Q.
Yamahara, Johji
Roufogalis, Basil D.
Li, Yuhao
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Salacia oblonga has been used for thousands of years in Ayurvedic medicine for the oral treatment of diabetes. The root extract has been shown to inhibit the activity of intestinal alpha-glucosidases, therefore S. oblonga holds potential as a natural method to mitigate the blood glucose response for people with diabetes. As part of a safety evaluation of novel ingredients for use in blood glucose control, the potential genotoxicity of a S.

Author(s): 
Flammang, A. M.
Erexson, G. L.
Mecchi, M. S.
Murli, H.
Publication Title: 
Diabetes, Obesity & Metabolism

AIMS: We investigated the effect of the water extract of Salacia oblonga (SOE), an ayurvedic antidiabetic and antiobesity medicine, on obesity and diabetes-associated cardiac hypertrophy and discuss the role of modulation of cardiac angiotensin II type 1 receptor (AT(1)) expression in the effect. METHODS: SOE (100 mg/kg) was given orally to male Zucker diabetic fatty (ZDF) rats for 7 weeks. At the end-point of the treatment, the hearts and left ventricles were weighed, cardiomyocyte cross-sectional areas were measured, and cardiac gene profiles were analysed.

Author(s): 
Huang, T. H.
He, L.
Qin, Q.
Yang, Q.
Peng, G.
Harada, M.
Qi, Y.
Yamahara, J.
Roufogalis, B. D.
Li, Y.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Activation of peroxisome proliferator-activated receptor (PPAR)-alpha by natural and synthetic chemicals induces hepatic hypertrophy. An aqueous extract of Salacia oblonga root (SOW) is an Ayurvedic medicine with anti-diabetic and anti-obesity properties. In the present study, it was found that SOW (100, 300 and 900mg/kg, once daily by oral gavage over a 28 day period) elicited dose-related increases in liver weight (LW) by 1.6%, 13.4% and 42.5%, respectively, and in the ratio of LW to body weight by 8.8%, 16.7% and 40.2%, respectively, in male rats.

Author(s): 
Rong, Xianglu
Kim, Moon Sun
Su, Ning
Wen, Suping
Matsuo, Yukimi
Yamahara, Johji
Murray, Michael
Li, Yuhao
Publication Title: 
Life Sciences

In many traditional schools of medicine it is claimed that a balanced modulation of several targets can provide a superior therapeutic effect and decrease in side effect profile compared to a single action from a single selective ligand, especially in the treatment of certain chronic and complex diseases, such as diabetes and obesity. Diabetes and obesity have a multi-factorial basis involving both genetic and environmental risk factors. A wide array of medicinal plants and their active constituents play a role in the prevention and treatment of diabetes.

Author(s): 
Li, Yuhao
Huang, Tom Hsun-Wei
Yamahara, Johji
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Kothala himbutu (Salacia reticulata) is a medicinal plant that has been used in Ayurvedic system of Indian and Sri Lankan traditional medicine to treat diabetes. AIM OF THE STUDY: This study aimed to clarify the mechanism(s) by which aqueous extracts of Kothala himbutu (KTE) stems decreases fasting blood glucose levels.

Author(s): 
Im, Ryanghyok
Mano, Hiroshi
Matsuura, Tomokazu
Nakatani, Sachie
Shimizu, Jun
Wada, Masahiro
Publication Title: 
Bioscience, Biotechnology, and Biochemistry

Kothala himbutu is a traditional Ayurvedic medicinal plant used to treat diabetes. We aimed to evaluate the safety of an aqueous extract of Kothala himbutu stem (KTE) in normal mice. The mice were divided into two groups: one was administered KTE and the other distilled water for 3 weeks. During the test period, the groups showed no significant differences in body weight gain or plasma parameters, such as fasting blood glucose level, oral glucose tolerance test, or aspartate transaminase (AST) or alanine transaminase (ALT) activity.

Author(s): 
Im, Ryanghyok
Mano, Hiroshi
Nakatani, Sachie
Shimizu, Jun
Wada, Masahiro

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