Salmonella Infections

Publication Title: 
PloS One

The immune response is essential for survival by destroying microorganisms and pre-cancerous cells. However, inflammation, one aspect of this response, can result in short- and long-term deleterious side-effects. Mclk1?/? mutant mice can be long-lived despite displaying a hair-trigger inflammatory response and chronically activated macrophages as a result of high mitochondrial ROS generation. Here we ask whether this phenotype is beneficial or simply tolerated. We used models of infection by Salmonella serovars and found that Mclk1?/?

Author(s): 
Wang, Dantong
Wang, Ying
Argyriou, Catherine
CarriËre, Audrey
Malo, Danielle
Hekimi, Siegfried
Publication Title: 
Indian Journal of Experimental Biology

To search for an herbal remedy for protection against and treatment for typhoid fever, a number of plants were screened. Anti-Salmonella activity of Terminalia belerica, an ingredient of Ayurvedic preparation 'triphala' used for treatment of digestive and liver disorders, has been reported. Fruits of T. belerica were extracted with petroleum ether, chloroform, acetone, alcohol and water and efficacy of extracts against Salmonella typhi and Salmonella typhimurium was evaluated. Alcoholic and water extracts of T.

Author(s): 
Madani, A.
Jain, S. K.
Publication Title: 
American Journal of Physiology. Cell Physiology

The Salmonella effector protein SigD is an inositol phosphate phosphatase that inhibits phosphatidylinositol 3-kinase-dependent signaling. Because epidermal growth factor (EGF) inhibits chloride secretion via phosphatidylinositol 3-kinase, we explored whether Salmonella infection might modify the inhibitory effect of EGF. As expected, EGF inhibited chloride secretion induced by carbachol in T(84) epithelial cells. Infection with wild-type (WT) but not sigD(-) mutant S. typhimurium SL1344 decreased CCh-stimulated chloride secretion.

Author(s): 
Bertelsen, Lone S.
Paesold, Günther
Marcus, Sandra L.
Finlay, Brett B.
Eckmann, Lars
Barrett, Kim E.
Publication Title: 
International Immunopharmacology

Yamoa (ground bark of Funtumia elastica tree) is marketed and sold as a dietary supplement with anecdotal therapeutic effects in the treatment of asthma and hay fever. We determined that Yamoa and Yamoa-derived polysaccharides affected innate immunity, in part, by priming gammadelta T cells. Gene expression patterns in purified bovine gammadelta T cells and monocytes induced by Yamoa were similar to those induced by ultrapure lipopolysaccharide (uLPS).

Author(s): 
Graff, Jill C.
Kimmel, Emily M.
Freedman, Brett
Schepetkin, Igor A.
Holderness, Jeff
Quinn, Mark T.
Jutila, Mark A.
Hedges, Jodi F.
Publication Title: 
American Journal of Public Health

In 1987 two Los Angeles County (California) hospitals reported four Latino patients with serious Salmonella arizona (Salmonella subgroup 3) infections who gave a medical history of taking rattlesnake capsules prior to illness. Capsules supplied by the patients or household members grew Salmonella arizona. We reviewed surveillance data for this Salmonella species and conducted a case-control study to determine the magnitude of this public health problem.

Author(s): 
Waterman, S. H.
Juarez, G.
Carr, S. J.
Kilman, L.
Publication Title: 
International Immunopharmacology

Yamoa (ground bark of Funtumia elastica tree) is marketed and sold as a dietary supplement with anecdotal therapeutic effects in the treatment of asthma and hay fever. We determined that Yamoa and Yamoa-derived polysaccharides affected innate immunity, in part, by priming gammadelta T cells. Gene expression patterns in purified bovine gammadelta T cells and monocytes induced by Yamoa were similar to those induced by ultrapure lipopolysaccharide (uLPS).

Author(s): 
Graff, Jill C.
Kimmel, Emily M.
Freedman, Brett
Schepetkin, Igor A.
Holderness, Jeff
Quinn, Mark T.
Jutila, Mark A.
Hedges, Jodi F.
Publication Title: 
BMC gastroenterology

BACKGROUND: Malnutrition affects the immune response, causing a decrease of defence mechanisms and making the host more susceptible to infections. Probiotics can reconstitute the intestinal mucosa and stimulate local and systemic immunity. The aim of this work was evaluate the effects of a probiotic fermented milk as a complement of a re-nutrition diet, on the recovery of the intestinal barrier, and mucosal and systemic immune functions in a murine model of non-severe protein-energy-malnutrition. Its potential protection against Salmonella enterica serovar Typhimurium (S.

Author(s): 
Maldonado Galdeano, Carolina
Novotny Núñez, Ivanna
de Moreno de LeBlanc, Alejandra
Carmuega, Esteban
Weill, Ricardo
Perdigón, Gabriela
Publication Title: 
Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology

A survey for Salmonella carriers in the Chinese army recruits was made. Each isolated strain was identified by conventional biochemical tests, rapid Inolex plates, and for identification serological methods. The rapid Inolex plates could save approximately 24-48 hours for identification. Salmonella was detected in 1.83% of the rectal swabs collected from 1,150 recruits and 50 cooks. Among the 22 isolates 5, 1, 5, and 6 strains were identified as Salmonella groups: B, C1, D and E1 respectively and 5 strains were ungroupable.

Author(s): 
Show, Y. S.
Chao, S. H.
Tai, F. H.
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