Salvia miltiorrhiza

Publication Title: 
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA

OBJECTIVE: To investigate the effect of Danhong injection on the cardiovascular, the respiratory, and the nervous systems in animals. METHODS: Using the pressure transducer, tension transducer and subcutaneous electrodes connected to a multifunctional signal processor, the femoral artery pressure, respiratory curve and electrocardiogram were recorded, respectively, in dogs before and after administration of Danhong injection. The effect of the injection on spontaneous activities was observed in mice using a multifunctional mouse activity recorder.

Author(s): 
Tai, Ming-Hui
Liu, Lan-Mei
Ma, Ren-Qiang
Li, Xue
Pang, Jian-Xin
Xu, Jiang-Ping
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

This study investigated the effect of Danshen on the pharmacodynamic-pharmacokinetic (PD-PK) effects of midazolam, a model CYP3A probe substrate. The effects of acute and 3-day Danshen treatment on the pharmacokinetics of a low dose midazolam (10 mg/kg, i.p.) were determined in vivo in the rat. Danshen (200 mg/kg, i.p.) treatment decreased midazolam clearance by 16%, with increases in the AUC by 22% and the half-life by 14%. 3-Day Danshen treatment (200 mg/kg/day, i.p.) for 3 days decreased the clearance, with increases in the T(1/2) and AUC.

Author(s): 
Wang, Xin
Lee, Wayne Y. W.
Zhou, Xuelin
Or, Penelope M. Y.
Yeung, John H. K.
Publication Title: 
Bioscience Trends

Hepatitis B induced by hepatitis B virus (HBV) remains a major public health problem worldwide. Although several antiviral drugs have been approved for hepatitis B, they cause significant dose-dependent side-effects (interferon-alpha) and drug resistance (lamivudine, etc.). Safe and potent new anti-HBV drugs are urgently needed. Traditional Chinese medicine (TCM) is an established segment of the health care system in China and widely used for hepatitis B in China and many parts of the world.

Author(s): 
Cui, Xiaoyan
Wang, Yueling
Kokudo, Norihiro
Fang, Dingzhi
Tang, Wei
Publication Title: 
Hepatobiliary & pancreatic diseases international: HBPD INT

OBJECTIVE: To determine the effect of Salviae miltiorrhizae on cirrhosis and portal hypertension by inhibiting nitric oxide synthase type II (NOSII) in rats. METHODS: Real time RT-PCR was used to detect the expression of NOSII mRNA. The enzymatic activity of nitric oxide synthase and the circulating levels of nitric oxide (NO), systemic and portal hemodynamics, and quantification of cirrhosis were measured with highly sensitive methods. Traditional Chinese medicine was utilized to treat cirrhotic rats and the function of NO was evaluated.

Author(s): 
Wang, Hai
Chen, Xiao-Ping
Qiu, Fa-Zu
Publication Title: 
Chemical & Pharmaceutical Bulletin

The multi-component fingerprinting method of Radix Salviae Miltiorrhizae (Root of Salvia miltiorrhiza BGE.), an important and popular medicinal herb in traditional Chinese medicine, was studied using reverse-phase HPLC and LC-MS-MS. Extract containing both the water-soluble phenolic compounds and nonpolar diterpenoid compounds known to be the herb's main bioactive components was prepared by a two-step extractive procedure.

Author(s): 
Hu, Ping
Liang, Qiong-Lin
Luo, Guo-an
Zhao, Zhong-Zhen
Jiang, Zhi-Hong
Publication Title: 
Journal of Chromatographic Science

Fufang Danshen (FFDS) is a famous typical Chinese complex prescription, which is mainly composed of Radix Salvia miltiorrhiza Bunge (SM) and Radix Panax notoginseng (PN). An HPLC method is developed to analyze SM, PN, and FFDS effectively; the effective analysis is achieved by using a gradient elution procedure with a mobile phase consisting of acetonitrile and 0.025% aqueous phosphoric acid (v/v). Through this method, 33 peaks in FFDS are clearly exhibited, and the components that make up the 33 peaks in FFDS are evaluated.

Author(s): 
Zeng, Guifeng
Liu, Jianxun
Wang, Longxing
Xu, Qing
Xiao, Hongbin
Liang, Xinmiao
Publication Title: 
Molecular Cancer Therapeutics

The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques.

Author(s): 
Efferth, Thomas
Kahl, Stefan
Paulus, Kerstin
Adams, Michael
Rauh, Rolf
Boechzelt, Herbert
Hao, Xiaojiang
Kaina, Bernd
Bauer, Rudolf
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

BACKGROUND AND OBJECTIVES: Many randomized controlled trials (RCTs) were conducted to evaluate the efficacy of DanShen (Salvia miltiorrhizae, an herbal medicine) on ischemic vascular diseases (IVD). However, there has been no systematic evaluation of the quality of DanShen RCTs so far. The aims of this study were (1) to assess the quality of DanShen RCTs on IVD published in mainland China from 1998 to 2007 and (2) to explore the factors correlating with the quality. DESIGN: A number of Chinese databases were searched, and most of DanShen RCTs on IVD were collected.

Author(s): 
Yu, Shicheng
Zhong, Baoliang
Zheng, Minghua
Xiao, Fangyi
Dong, Zhibing
Zhang, Huaiqing
Publication Title: 
Chemical & Pharmaceutical Bulletin

The fingerprint technique has been studied frequently as a useful strategy for quality of traditional Chinese medicine. A novel potency fingerprint that can quantitatively analyze the antioxidant activity of individual constituent and provide the total antioxidant activities of the samples has been developed by high-performance liquid chromatography coupled with ultraviolet and pyrogallol-luminol chemiluminescence detection (HPLC-diode array detection (DAD)-PLD).

Author(s): 
Chang, Yan-Xu
Yan, Dong-Mei
Chen, Lin-Lin
Ding, Xiao-Ping
Qi, Jin
Kang, Li-Yuan
Zhang, Bo-li
Yu, Bo-Yang
Publication Title: 
Bioscience Trends

Hepatitis B induced by hepatitis B virus (HBV) remains a major public health problem worldwide. Although several antiviral drugs have been approved for hepatitis B, they cause significant dose-dependent side-effects (interferon-alpha) and drug resistance (lamivudine, etc.). Safe and potent new anti-HBV drugs are urgently needed. Traditional Chinese medicine (TCM) is an established segment of the health care system in China and widely used for hepatitis B in China and many parts of the world.

Author(s): 
Cui, Xiaoyan
Wang, Yueling
Kokudo, Norihiro
Fang, Dingzhi
Tang, Wei

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