Sapogenins

Publication Title: 
Journal of AOAC International

Because Ayurvedic herbal preparations contain a myriad of compounds in complex matrixes, it is difficult to establish quality control standards for raw materials and to standardize finished Ayurvedic drugs. A novel, accurate, and valid fingerprint method was developed using HPLC for quality control of a traditional Ayurvedic Arjuna churna formulation, which is used as a cardiotonic drug.

Author(s): 
Chitlange, Sohan S.
Kulkarni, Prajakta S.
Patil, Dada
Patwardhan, Bhushan
Nanda, Rabindra K.
Publication Title: 
The American Journal of Chinese Medicine

Colorectal cancer remains one of the most prevalent cancer and a leading cause of cancer related death in the US. Many currently used chemotherapeutic agents are derived from botanicals. Identifying herbal sources, including those from ginseng family, to develop better anti-cancer therapies remains an essential step in advancing the treatment of the cancer. In this article, potential roles of ginseng herbs, especially American ginseng and notoginseng, in colorectal cancer therapeutics are presented.

Author(s): 
Wang, Chong-Zhi
Yuan, Chun-Su
Publication Title: 
Anti-Cancer Drugs

Protopanaxadiol (PPD), an aglycon of ginseng saponins, has shown anticancer activity in earlier studies. Here, we have reported the semisynthesis of nine PPD derivatives with acetyl substitutions. Subsequently, the antiproliferative effects of these nine analogs on different human cancer cell lines have been investigated. Compounds 1, 3, and 5 showed more significant and more potent antiproliferative activity compared with PPD and other derivatives.

Author(s): 
Du, Guang-Jian
Dai, Qing
Williams, Stainley
Wang, Chong-Zhi
Yuan, Chun-Su
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Protopanaxadiol (PPD) is a triterpenoid that can be prepared from steamed ginseng. PPD possesses anticancer potential via caspase-dependent apoptosis. Whether paraptosis, a type of the caspase-independent cell death, is also induced by PPD has not been evaluated. METHODS: Cell death, the cell cycle and intracellular reactive oxygen species (ROS) were analyzed by flow cytometry after staining with annexin V/PI, PI/RNase or H2DCFDA. We observed morphological changes by crystal violet staining assay. Mitochondrial swelling was measured by ultraviolet-visible spectrophotometry.

Author(s): 
Wang, Chong-Zhi
Li, Binghui
Wen, Xiao-Dong
Zhang, Zhiyu
Yu, Chunhao
Calway, Tyler D.
He, Tong-Chuan
Du, Wei
Yuan, Chun-Su
Publication Title: 
Oncology Reports

Plant-derived active constituents and their semi-synthetic or synthetic analogs have served as major sources of anticancer drugs. 20(S)-protopanaxadiol (PPD) is a metabolite of ginseng saponin of both American ginseng (Panax quinquefolius L.) and Asian ginseng (Panax ginseng C.A. Meyer). We previously demonstrated that ginsenoside Rg3, a glucoside precursor of PPD, exhibits anti-proliferative effects on HCT116 cells and reduces tumor size in a xenograft model.

Author(s): 
Gao, Jian-Li
Lv, Gui-Yuan
He, Bai-Cheng
Zhang, Bing-Qiang
Zhang, Hongyu
Wang, Ning
Wang, Chong-Zhi
Du, Wei
Yuan, Chun-Su
He, Tong-Chuan
Publication Title: 
Mutagenesis

A majority of potential radioprotective synthetic compounds have demonstrated limited clinical application owing to their inherent toxicity, and thus, the seeking of naturally occurring herbal products, such as ginseng, for their radioprotective capability has become an attractive alternative. In general, ginseng refers to the roots of the species of the genus Panax. As a medicinal herb, ginseng has been widely used in traditional Chinese medicine for its wide spectrum of medicinal effects, such as tonic, immunomodulatory, antimutagenic, adaptogenic and antiaging activities.

Author(s): 
Lee, Tung-Kwang
Johnke, Roberta M.
Allison, Ron R.
O'Brien, Kevin F.
Dobbs, Larry J.
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