Schistosomiasis

Publication Title: 
The American Journal of Tropical Medicine and Hygiene

The sleeping-time induced by sodium pentobarbital is greatly increased in mice experimentally infected with Schistosoma mansoni. The degree of hypnosis is affected by the female worm burden, probably because the hepatic lesions produced by schistosome eggs cause slow metabolisation of anesthetics.

Author(s): 
Coelho, P. M.
Freire, A. C.
Araujo, F. G.
Pellegrino, J.
Pereira, L. H.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Artemether (ART) is a well-described antimalarial with efficacy against juvenile schistosomes, with 7-day-old schistosomula being particularly susceptible. Both ART-affected worms and parasites developing from irradiated cercariae die at similar times after infection. Our aim was to determine if ART treatment of prepatent schistosomiasis japonica may result in the generation of a protective immune response. Female CBA mice were treated with a single dose of ART at defined time points after percutaneous infection with a virulent Chinese mainland strain of Schistosoma japonicum.

Author(s): 
Bartley, Paul B.
Glanfield, Amber
Li, Yuesheng
Stanisic, Danielle I.
Duke, Mary
Jones, Malcolm K.
McManus, Donald P.
Publication Title: 
Parasites & Vectors

BACKGROUND: Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s. In this article, we conducted a systematic review and meta-analysis to evaluate the antischistosomal efficacy of different medication strategies including monotherapy or combination therapies of these drugs.

Author(s): 
Liu, Rong
Dong, Hui-Fen
Guo, Yi
Zhao, Qin-Ping
Jiang, Ming-Sen
Publication Title: 
PloS One

BACKGROUND: Chemotherapy based on repeated doses of praziquantel is still the most effective control strategy against Schistosomiasis, however artemisinin derivatives emerged as a family of compounds with schistomicide activity. The aim of the present work is to compare the efficacy of artemisinin-based therapies in the treatment and prophylaxis of human schistosomiasis. The design of this work involved a quantitative systematic review and meta-analysis.

Author(s): 
Pérez del Villar, Luis
Burguillo, Francisco J.
López-Abán, Julio
Muro, Antonio
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