Schistosomiasis haematobia

Publication Title: 
The Journal of Infectious Diseases

Recently, artemisinin derivatives have been shown to be efficacious in chemoprophylaxis of and chemotherapy for Schistosoma japonicum and S. mansoni infections. Therefore, a double-blind, randomized, placebo-controlled study was carried out to investigate the efficacy and tolerability of artesunate plus placebo and the combination of artesunate and praziquantel in the treatment of S. haematobium infections in Gabon.

Author(s): 
Borrmann, S.
Szlezák, N.
Faucher, J. F.
Matsiegui, P. B.
Neubauer, R.
Binder, R. K.
Lell, B.
Kremsner, P. G.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Artemether is an efficacious antimalarial drug that also displays antischistosomal properties. Laboratory studies have found that artemether curtails the development of adult worms of Schistosoma japonicum, S. mansoni and S. haematobium, and thus prevents morbidity. These findings have been confirmed in clinical trials for the former two parasites; administered orally once every 2-3 weeks, artemether significantly reduced the incidence and intensity of patent infections. Here, we present the first randomized, double-blind, placebo-controlled trial of artemether against S.

Author(s): 
N'Goran, Eliézer K.
Utzinger, Jürg
Gnaka, Henri N.
Yapi, Ahoa
N'Guessan, Nicaise A.
Kigbafori, Silué D.
Lengeler, Christian
Chollet, Jacques
Shuhua, Xiao
Tanner, Marcel
Publication Title: 
PloS One

BACKGROUND: This study was conducted to determine the efficacy of the antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma haematobium in school aged children. METHODOLOGY/PRINCIPAL FINDINGS: The study was conducted in Djalakorodji, a peri-urban area of Bamako, Mali, using a double blind setup in which As+SMP was compared with praziquantel (PZQ). Urine samples were examined for Schistosoma haematobium on days -1, 0, 28 and 29.

Author(s): 
Sissoko, Mahamadou S.
Dabo, Abdoulaye
Traoré, Hamidou
Diallo, Mouctar
Traoré, Boubacar
Konaté, Drissa
Niaré, Boubacar
Diakité, Moussa
Kamaté, Bourama
Traoré, Abdrahamane
Bathily, Aboudramane
Tapily, Amadou
Touré, Ousmane B.
Cauwenbergh, Sarah
Jansen, Herwig F.
Doumbo, Ogobara K.
Publication Title: 
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

BACKGROUND: Morbidity control of schistosomiasis relies on a single drug, praziquantel. The antimalarial drug mefloquine possesses interesting antischistosomal properties, yet no clinical studies have been performed. METHODS: We conducted a randomized, exploratory open-label trial to assess the efficacy and safety of mefloquine (25 mg/kg), artesunate (3 doses of 4 mg/kg), mefloquine-artesunate (3 doses of 100 mg artesunate plus 250 mg mefloquine), and praziquantel (40 mg/kg) against Schistosoma haematobium.

Author(s): 
Keiser, Jennifer
N'Guessan, Nicaise A.
Adoubryn, Koffi D.
Silué, Kigbafori D.
Vounatsou, Penelope
Hatz, Christoph
Utzinger, Jürg
N'Goran, Eliézer K.
Publication Title: 
Pathogens and Global Health

OBJECTIVE: Efficacy of artemisinin derivatives alone or in combination compared to praziquantel alone for the treatment of urinary schistosomiasis in schoolchildren. METHODS: Randomized clinical trials comparing praziquantel with artemisinin derivatives in the treatment of urinary schistosomiasis in schoolchildren were included. Medline, EMBASE, LILACS, CENTRAL, African Index Medicus, and Scielo were searched. We also analyzed the abstracts of the main conferences on infectious diseases and tropical medicine during the years 2009-2011. Google Scholar and OpenSIGLE were also searched.

Author(s): 
Wikman-Jorgensen, Philip Erik
Henríquez-Camacho, César Augusto
Serrano-Villar, Sergio
Pérez-Molina, Jose Antonio
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Urinary schistosomiasis is caused by an intravascular infection with parasitic Schistosoma haematobium worms. The adult worms typically migrate to the venous plexus of the human bladder and excrete eggs which the infected person passes in their urine. Chronic infection can cause substantial morbidity and long-term complications as the eggs become trapped in human tissues causing inflammation and fibrosis. We summarised evidence of drugs active against the infection. This is new edition of a review first published in 1997.

Author(s): 
Kramer, Christine V.
Zhang, Fan
Sinclair, David
Olliaro, Piero L.
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