Schistosomiasis japonica

Publication Title: 
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases

In this paper, the effect of Schistosoma japonicum infection on liver drug-metabolizing enzymes of mice was studied. The prolongation of hypnosis duration of sodium pentobarbital in vivo and the inhibition of liver aniline hydroxylase (AH), aminopyrine N-demethylase (APD) as well as cytochrome P-450 (Cyt P-450) in vitro were observed in mice infected with 20, 40 and 60 cercariae of S. japonicum after 6 weeks.

Author(s): 
Wang, J.
Qiu, Z. Y.
Xie, W.
Wu, Y. Y.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

Mice infected with 100 and 50 Schistosoma japonicum cercariae for 7 and 35 d respectively were treated with im artemether 100 mg.kg-1.d-1 or arteether 100 and 300 mg.kg-1.d-1 for 2 d. The mice were killed at different intervals within 28 d after medication and the livers were sectioned for histological and histochemical observations. The results showed that both artemether and arteether caused degeneration in the tegument, intestine and genital gland of the hepatic-shifted worms.

Author(s): 
Yin, J. W.
Yang, Y. Q.
Xiao, S. H.
Li, Y.
Jiang, H. J.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

Artemether (beta-methyl ether of artemisinin) first synthesized by Shanghai Institute of Materia Medica, Chinese Academy of Sciences(1), appears in colorless crystal and is more lipid-soluble than artemisinin. When artemether was given ig or im to mice infected with Schistosoma japonicum for 32-35 d at the dosage of 1/10-1/2 LD50. Its effects in the two administration routes were similar.

Author(s): 
You, J. Q.
Mei, J. Y.
Xiao, S. H.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

The first single dose of praziquantel (Pra) was given ig to mice on the day of infection with Schistosoma japonicum cercariae, or 7 d, 14 d, and 21 d after infection. Afterwards, the same dose of Pra was given once at 1-3 wk intervals for 2-3 times. The prophylactic effect was estimated by the reduction of average number of total and female worms, the number of mice without female worm, and the gross change of the liver.

Author(s): 
Xiao, S. H.
You, J. Q.
Mei, J. Y.
Jiao, P. Y.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

Artemether (Art, beta-methyl ether of artemisinin) first synthesized by Shanghai Institute of Materia Medica, Chinese Academy of Sciences, is effective against not only malaria but also schistosomiasis. When rabbits infected with Schistosoma japonicum cercariae for 7 d were treated ig with Art 10 mg.kg-1, the total worm reduction rates were 74.6-76.7%. If Art (10 mg.kg-1) was given once weekly after the first treatment for 3-4 times, the total worm reduction rate was > 98%, and most of the rabbits were free from female worms.

Author(s): 
Xiao, S. H.
You, J. Q.
Mei, J. Y.
Jiao, P. Y.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

To study the histopathological change of the liver of the hosts treated with artemether (Art) or praziquantel (Pra) in early stage after infection with Schistosoma japonicum cercariae. METHODS: Dogs infected once with schistosome cercariae were treated ig with Art 10 mg.kg-1 or Art capsule (ArtC) 15 mg.kg-1 on d 7, or praziquantel (Pra) 30-40 mg.kg-1 on d 21 after infection, followed by the repeated dosing once every 1 or 2 wk for 2-4 times.

Author(s): 
Xiao, S. H.
Yang, Y. Q.
Zhang, C. W.
You, J. Q.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the effect of artemether (Art) on glyceraldehyde-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), and pyruvate kinase (PK) of S japanicum. METHODS: Mice infected with schistosome cercariae for 32-38 d were treated ig with Art 100-300 mg.kg-1 and killed 24-72 h after medication for collection of schistosomes. The activities of GAPDH, PGK, and PK of the worms were determined by measuring the formation of NADH or consumption of NAD. The lactate content of the worms was also measured.

Author(s): 
Xiao, S. H.
You, J. Q.
Guo, H. F.
Jiao, P. Y.
Mei, J. Y.
Yao, M. Y.
Feng, Z.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the effect of artemether (Art) for prevention of schistosomal infection. METHODS: Rabbits with single infection or reinfection with Schistosoma japonicum cercariae were treated intramuscularly (i.m.) or intragastrically (i.g.) with Art 5 -20 mg.kg-1 on d 7-15 after the first infection, followed by various regimens. RESULTS: When rabbits were injected i.m. Art 7.5 mg.kg-1 (i.e., one half of the effective dose given i.g. on d 7) followed by once every week for twice, the female worm reduction rate was only 42%. In infected rabbits treated i.g.

Author(s): 
Xiao, S. H.
You, J. Q.
Mei, J. Y.
Jiao, P. Y.
Guo, H. F.
Feng, Z.
Publication Title: 
Bulletin of the World Health Organization

OBJECTIVE: To evaluate the safety and efficacy of combining artemether (AM) and praziquantel (PZQ) in different regimens for treating acute schistosomiasis japonica. METHODS: We undertook a randomized, double-blind, placebo-controlled trial within four specialized schistosomiasis hospitals in the Dongting Lake region, Hunan province, China, between May 2003 and December 2005.

Author(s): 
Hou, Xun-Ya
McManus, Donald P.
Gray, Darren J.
Balen, Julie
Luo, Xin-Song
He, Yong-Kang
Ellis, Magda
Williams, Gail M.
Li, Yue-Sheng
Publication Title: 
Journal of Biomedicine & Biotechnology

In chronic infectious diseases, such as schistosomiasis, pathogen growth and immunopathology are affected by the induction of a proper balanced Th1/Th2 response to the pathogen and by antigen-triggered activation-induced T cell death. Here, by using S. japonicum infection or schistosome antigens-immunized mouse model, or antigens in vitro stimulation, we report that during the early stage of S.

Author(s): 
Xu, Xinyu
Wen, Xiaoyun
Chi, Ying
He, Lei
Zhou, Sha
Wang, Xuefeng
Zhao, Jiaqing
Liu, Feng
Su, Chuan

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