Sciatic Nerve

Publication Title: 
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas M�dicas E Biol�gicas / Sociedade Brasileira De Biof�sica ... [et Al.]

Terpineol, a volatile terpenoid alcohol of low toxicity, is widely used in the perfumery industry. It is an important chemical constituent of the essential oil of many plants with widespread applications in folk medicine and in aromatherapy. The effects of terpineol on the compound action potential (CAP) of rat sciatic nerve were studied. Terpineol induced a dose-dependent blockade of the CAP. At 100 microM, terpineol had no demonstrable effect.

Author(s): 
Moreira, M. R.
Cruz, G. M.
Lopes, M. S.
Albuquerque, A. A.
Leal-Cardoso, J. H.
Publication Title: 
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas M�dicas E Biol�gicas / Sociedade Brasileira De Biof�sica ... [et Al.]

Estragole, a relatively nontoxic terpenoid ether, is an important constituent of many essential oils with widespread applications in folk medicine and aromatherapy and known to have potent local anesthetic activity. We investigated the effects of estragole on the compound action potential (CAP) of the rat sciatic nerve. The experiments were carried out on sciatic nerves dissected from Wistar rats.

Author(s): 
Leal-Cardoso, J. H.
Matos-Brito, B. G.
Lopes-Junior, J. E. G.
Viana-Cardoso, K. V.
Sampaio-Freitas, A. B.
Brasil, R. O.
Coelho-de-Souza, A. N.
Albuquerque, A. a. C.
Publication Title: 
The Journal of Pharmacy and Pharmacology

Axonal regeneration is important for functional recovery following nerve damage. Centella asiatica Urban herb, also known as Hydrocotyle asiatica L., has been used in Ayurvedic medicine for centuries as a nerve tonic. Here, we show that Centella asiatica ethanolic extract (100 microg mL-1) elicits a marked increase in neurite outgrowth in human SH-SY5Y cells in the presence of nerve growth factor (NGF). However, a water extract of Centella was ineffective at 100 microg mL-1.

Author(s): 
Soumyanath, Amala
Zhong, Yong-Ping
Gold, Sandra A.
Yu, XiaoLin
Koop, Dennis R.
Bourdette, Dennis
Gold, Bruce G.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally, Acorus calamus has been used for the treatment and management of headache, migraine, body ache and severe inflammatory pain in the Unani, Ayurveda and Indian system of medicine. AIM OF THE STUDY: Present study focuses on the evaluation of saponin rich extract of Acorus calamus (SRE-AC) in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain and neuronal functional changes in rats.

Author(s): 
Muthuraman, Arunachalam
Singh, Nirmal
Publication Title: 
Pharmaceutical Biology

CONTEXT: Guggulipid is a neutral fraction of ethyl acetate extract of gum resin of the tree Commiphora mukul Engl. (Burseraceae) and used in Ayurvedic medicine for treatment of neurological disorders. OBJECTIVES: The present study was undertaken to assess the antiallodynic and antihyperalgesic activities of guggulipid in rats. MATERIALS AND METHODS: The screening study included the CCI and L5-L6 SNL models of neuropathic pain. Guggulipid (100 and 50 mg/kg) or saline was administered intraperitoneally in a blinded, randomized manner from postoperative day (POD) 7 to 13.

Author(s): 
Goyal, Sachin
Khilnani, Gurudas
Singhvi, Indrajeet
Singla, Shivali
Khilnani, Ajeet K.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

In diabetes, activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is an important effector of oxidative-nitrosative injury, which contributes to the development of experimental diabetic peripheral neuropathy (DPN). However, the potential toxicity of complete PARP inhibition necessitates the utilization of weaker PARP inhibitors with additional therapeutic properties. Nicotinamide (vitamin B3) is a weak PARP inhibitor, antioxidant, and calcium modulator and can improve energy status and inhibit cell death in ischemic tissues.

Author(s): 
Stevens, M. J.
Li, F.
Drel, V. R.
Abatan, O. I.
Kim, H.
Burnett, D.
Larkin, D.
Obrosova, I. G.
Publication Title: 
International Journal of Molecular Medicine

We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabetic peripheral neuropathy.

Author(s): 
Watcho, Pierre
Stavniichuk, Roman
Tane, Pierre
Shevalye, Hanna
Maksimchyk, Yury
Pacher, Pal
Obrosova, Irina G.
Publication Title: 
Brain Research

Earlier research has demonstrated that hyperbaric oxygen (HBO2) can produce an antinociceptive effect in models of acute pain. Recent studies have revealed that HBO2 can produce pain relief in animal models of chronic pain as well. The purpose of the present investigation was to ascertain whether HBO2 treatment might suppress allodynia in rats with neuropathic pain and whether this effect might be blocked by the opioid antagonist naltrexone (NTX).

Author(s): 
Gibbons, Carlee R.
Liu, Shulin
Zhang, Yangmiao
Sayre, Casey L.
Levitch, Briana R.
Moehlmann, Sarah B.
Shirachi, Donald Y.
Quock, Raymond M.
Publication Title: 
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]

Terpineol, a volatile terpenoid alcohol of low toxicity, is widely used in the perfumery industry. It is an important chemical constituent of the essential oil of many plants with widespread applications in folk medicine and in aromatherapy. The effects of terpineol on the compound action potential (CAP) of rat sciatic nerve were studied. Terpineol induced a dose-dependent blockade of the CAP. At 100 microM, terpineol had no demonstrable effect.

Author(s): 
Moreira, M. R.
Cruz, G. M.
Lopes, M. S.
Albuquerque, A. A.
Leal-Cardoso, J. H.
Publication Title: 
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]

Estragole, a relatively nontoxic terpenoid ether, is an important constituent of many essential oils with widespread applications in folk medicine and aromatherapy and known to have potent local anesthetic activity. We investigated the effects of estragole on the compound action potential (CAP) of the rat sciatic nerve. The experiments were carried out on sciatic nerves dissected from Wistar rats.

Author(s): 
Leal-Cardoso, J. H.
Matos-Brito, B. G.
Lopes-Junior, J. E. G.
Viana-Cardoso, K. V.
Sampaio-Freitas, A. B.
Brasil, R. O.
Coelho-de-Souza, A. N.
Albuquerque, A. a. C.

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