Scutellaria baicalensis

Publication Title: 
PloS One

The number of fully active antibiotic options that treat nosocomial infections due to multidrug-resistant Acinetobacter baumannii (A. baumannii) is extremely limited. Magnolia officinalis, Mahonia bealei, Rabdosia rubescens, Rosa rugosa, Rubus chingii, Scutellaria baicalensis, and Terminalia chebula plant extracts were previously shown to have growth inhibitory activity against a multidrug-resistant clinical strain of A. baumannii.

Author(s): 
Miyasaki, Yoko
Rabenstein, John D.
Rhea, Joshua
Crouch, Marie-Laure
Mocek, Ulla M.
Kittell, Patricia Emmett
Morgan, Margie A.
Nichols, Wesley Stephen
Van Benschoten, M. M.
Hardy, William David
Liu, George Y.
Publication Title: 
Cancer Research

Scutellaria baicalensis is a widely used Chinese herbal medicine that has been used historically in anti-inflammatory and anticancer therapy. The purpose of this study is to verify its anticancer activity on head and neck squamous cell carcinoma (HNSCC) in vitro and in vivo and to investigate its effect on cyclooxygenase-2 (COX-2), which converts arachidonic acid to prostaglandin E(2) (PGE(2)) and is highly expressed in HNSCC.

Author(s): 
Zhang, David Y.
Wu, Josephine
Ye, Fei
Xue, Li
Jiang, Shiquan
Yi, Jizu
Zhang, Wandi
Wei, Huachen
Sung, Max
Wang, Wayne
Li, Xiaoping
Publication Title: 
The Journal of Pharmacy and Pharmacology

Ritonavir, a protease inhibitor drug, is commonly used in AIDS therapy. As with other chemotherapeutic drugs that cause gastrointestinal adverse effects, ritonavir treatment is associated with significant nausea and vomiting. This study investigated whether Scutellaria baicalensis, and its active flavonoid constituent, baicalein, attenuate the gastrointestinal effects of ritonavir. The effects of herb administration were evaluated in ritonavir-treated rats using a rat pica model, which simulates nausea and vomiting in humans.

Author(s): 
Mehendale, Sangeeta
Aung, Han
Wang, Chong-Zhi
Tong, Robin
Foo, Adela
Xie, Jing-Tian
Yuan, Chun-Su
Publication Title: 
Journal of Inorganic Biochemistry

Baicalein and baicalin, the major bioactive compounds found in the Chinese herb Scutellaria baicalensis, have been shown to be effective against cancer, bacterial infections and oxidative stress diseases. However, little is known about their mechanisms of action. To probe whether iron homeostasis modulation may play a role in their bioactivity, we have investigated their iron binding characteristics under physiologically relevant conditions.

Author(s): 
Perez, Carlos A.
Wei, Yibin
Guo, Maolin
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Based on our previous observation, the whole Scutellaria baicalensis extract (SbE) did not show significant breast cancer cell inhibitory effect. In this study, we isolated a baicalin-deprived-fraction (SbF1) of Scutellaria baicalensis, and baicalin-fraction (SbF3), and evaluated their anti-breast cancer properties using MCF-7 cells. The content of four flavonoids in extract/fractions were determined using high performance liquid chromatography. Analytical data showed that in SbF1, the major constituents are baicalein and wogonin, while SbF3 only contains baicalin.

Author(s): 
Wang, Chong-Zhi
Li, Xiao-Li
Wang, Qian-Fei
Mehendale, Sangeeta R.
Yuan, Chun-Su
Publication Title: 
Biochimica Et Biophysica Acta

Scutellaria baicalensis (SB) and SB-derived polyphenols possess anti-proliferative activities in several cancers, including pancreatic cancer (PaCa). However, the precise molecular mechanisms have not been fully defined. SB extract and SB-derived polyphenols (wogonin, baicalin, and baicalein) were used to determine their anti-proliferative mechanisms. Baicalein significantly inhibited the proliferation of PaCa cell lines in a dose-dependent manner, whereas wogonin and baicalin exhibited a much less robust effect.

Author(s): 
Takahashi, Hiroki
Chen, Monica C.
Pham, Hung
Angst, Eliane
King, Jonathan C.
Park, Jenny
Brovman, Ethan Y.
Ishiguro, Hideyuki
Harris, Diane M.
Reber, Howard A.
Hines, Oscar J.
Gukovskaya, Anna S.
Go, Vay Liang W.
Eibl, Guido
Publication Title: 
Journal of Cellular Biochemistry

The cardiotoxicity of doxorubicin limits its clinical use in the treatment of a variety of malignancies. Previous studies suggest that doxorubicin-associated cardiotoxicity is mediated by reactive oxygen species (ROS)-induced apoptosis. We therefore investigated if baicalein, a natural antioxidant component of Scutellaria baicalensis, could attenuate ROS generation and cell death induced by doxorubicin. Using an established chick cardiomyocyte model, doxorubicin (10 µM) increased cell death in a concentration- and time-dependent manner.

Author(s): 
Chang, Wei-Tien
Li, Jing
Haung, Hsien-Hao
Liu, Huiping
Han, Mei
Ramachandran, Srinivasan
Li, Chang-Qing
Sharp, Willard W.
Hamann, Kimm J.
Yuan, Chun-Su
Hoek, Terry L. Vanden
Shao, Zuo-Hui
Publication Title: 
The American Journal of Chinese Medicine

Ischemic heart disease (IHD) is one of the leading causes of death in Western countries. Prevention rather than treatment of heart disease can significantly improve patients' quality of life and reduce health care costs. Flavonoids are widely distributed in vegetables, fruits and herbal medicines. Regularly consuming botanicals, especially those containing flavonoids, has been associated with a reduction in cardiovascualar disease; thus, it is important to investigate how flavonoids improve cardiac resistance to heart disease and their related mechanisms of action.

Author(s): 
Wang, Chong-Zhi
Mehendale, Sangeeta R.
Calway, Tyler
Yuan, Chun-Su
Publication Title: 
Pancreas

OBJECTIVES: Scutellaria baicalensis has been a subject of research interest due to its potential multiple therapeutic benefits. This study was to examine the distribution of baicalein, wogonin, oroxylin A and their glucuronide/sulfate-conjugated metabolites in plasma, colon, small intestine, lung, liver, pancreas, kidney, and prostate tissues and in pancreatic tumor in a xenograft animal model. In addition, we examined metabolic stability of baicalin in these tissues.

Author(s): 
Lu, Qing-Yi
Zhang, Lifeng
Moro, Aune
Chen, Monica C.
Harris, Diane M.
Eibl, Guido
Go, Vay-Liang W.
Publication Title: 
International Journal of Oncology

Scutellaria baicalensis extract (SbE) has been shown to exert chemopreventive effects on several types of cancer. Baicalin, a hydrophilic flavonoid found in SbE, may have opposing effects that decrease the antitumor potential of SbE against colorectal cancer. In this study, after removing baicalin, we prepared an aglycone-rich fraction (ARF) of SbE and evaluated its anti-proliferative activity and mechanisms of action. The flavonoids found in ARF, baicalin fraction (BF) and SbE were determined by high-performance liquid chromatography (HPLC).

Author(s): 
Wang, Chong-Zhi
Calway, Tyler D.
Wen, Xiao-Dong
Smith, Jacob
Yu, Chunhao
Wang, Yunwei
Mehendale, Sangeeta R.
Yuan, Chun-Su

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