Selenium

Publication Title: 
International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics

BACKGROUND: The use of complementary and alternative medicine (CAM) by patients and physicians has increased markedly in recent years. Many case reports, case series, and uncontrolled trials of varying quality have been completed; however, there is now a slowly increasing number of randomized controlled trials (RCTs) examining the use of CAM. OBJECTIVES: To identify, survey, and review RCTs investigating the use of CAM for infertility treatment. SEARCH STRATEGY: The MEDLINE and Cochrane databases were electronically searched.

Author(s): 
Clark, Natalie A.
Will, Matthew
Moravek, Molly B.
Fisseha, Senait
Publication Title: 
Molecular Nutrition & Food Research

Prostate cancer is the second most common cancer in men worldwide. Despite the global importance of this cancer, until recently little was known about risk factors apart from the well-established factors: age, family history and country of birth. The large worldwide variation in prostate cancer risk and increased risk in migrants moving from low to high risk countries provides strong support for modifiable environmental factors.

Author(s): 
Itsiopoulos, Catherine
Hodge, Allison
Kaimakamis, Mary
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Pretreatment of male rats with phenobarbital markedly depressed the duration of pentobarbital hypnosis and stimulated the hepatic microsomal metabolism of ethylmorphine and aniline. Following selenium treatment there was a prolongation of pentobarbital hypnosis and an inhibition of metabolism of ethylmorphine with no effect on that of aniline. When phenobarbital and selenium were administered simultaneously, the opposing effects on the duration of pentobarbital hypnosis cancelled each other.

Author(s): 
Schnell, R. C.
Early, J. L.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Three days after pretreatment of rats of both sexes with sodium selenite (2.4 mg Se/kg, ip) the duration of pentobarbital-induced hypnosis was potentiated in males but not females. Similar treatment with selenium led to a significant inhibition of ethylmorphine demethylase activity by hepatic microsomal enzymes obtained from male but not female rats. Selenium treatment did not alter the activity of aniline hydroxylase in animals of either sex.

Author(s): 
Schnell, R. C.
Early, J. L.
Publication Title: 
Experientia
Author(s): 
Schnell, R. C.
Early, J. L.
Publication Title: 
The Journal of Nutritional Biochemistry

The present studies characterized the influence of dietary selenium (Na2SeO3) on the duration of pentobarbital (PB) induced hypnosis (sleep) in the rat. Rats were fed semipurified diets varying from 0.01 to 2.0 mg Se/kg for up to 4 weeks. Consumption of diets containing 1.0 and 2.0 mg Se/kg significantly prolonged PB induced hypnosis. Hepatic selenium, but not hepatic glutathione peroxidase activity, correlated with the length of PB induced hypnosis. The prolongation of hypnosis caused by diets containing 1.0 mg Se/kg was substantially reduced or eliminated by repeated exposure to PB.

Author(s): 
Debski, Bogdan
Milner, John A.
Publication Title: 
The American Journal of Clinical Nutrition

Young female mice were fed torula-yeast-based diets deficient in vitamin E or selenium or supplemented with cod-liver oil to determine the effect of host antioxidant status on the therapeutic efficacy of the Chinese traditional antimalarial drug qinghaosu (QHS), a sesquiterpene endoperoxide. Vitamin E deficiency enhanced the antimalarial action of QHS against Plasmodium yoelii, both in terms of decreased parasitemia and improved survival but Se deficiency did not.

Author(s): 
Levander, O. A.
Ager, A. L.
Morris, V. C.
May, R. G.
Publication Title: 
The Medical Journal of Malaysia

Neem, Azadirachta indica, is a plant from the family Meliaceae, known as "Pokok Semambu" in Malay community. It has been extensively used in India as traditional Ayurvedic and folklore minedicine for the treatment of various diseases. This study aimed to determine the distribution of selenium in the liver of rats during hepatocarcinogenesis when neem aqueous extract and dietary selenium was supplemented.

Author(s): 
Hanachi, P.
Loh, L. N.
Fauziah, O.
Rafiuz, Z. H.
Tee, S. T.
Lye, C. W.
Lam, T. P.
Publication Title: 
Cancer

BACKGROUND: To the authors' knowledge, few studies have been conducted to date regarding dietary selenium and the potential gene-nutrient interactions with single-nucleotide polymorphisms (SNPs) in different pathways on the risk of esophageal cancer.

Author(s): 
Cai, Lin
You, Nai-Chieh Yuko
Lu, Hua
Mu, Li-Na
Lu, Qing-Yi
Yu, Shun-Zhang
Le, Anh D.
Marshall, James
Heber, David
Zhang, Zuo-Feng
Publication Title: 
Molecular Nutrition & Food Research

Selenium (Se) is a potent nutritional antioxidant that carries out biological effects through its incorporation into selenoproteins. Given the crucial roles that selenoproteins play in regulating reactive oxygen species (ROS) and redox status in nearly all tissues, it is not surprising that dietary Se strongly influences inflammation and immune responses. The notion that Se "boosts" the immune system has been supported by studies involving aging immunity or protection against certain pathogens.

Author(s): 
Hoffmann, Peter R.
Berry, Marla J.

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