Sensory Receptor Cells

Publication Title: 
PLoS genetics

Ethosuximide is a medication used to treat seizure disorders in humans, and we previously demonstrated that ethosuximide can delay age-related changes and extend the lifespan of the nematode Caenorhabditis elegans. The mechanism of action of ethosuximide in lifespan extension is unknown, and elucidating how ethosuximide functions is important for defining endogenous processes that influence lifespan and for exploring the potential of ethosuximide as a therapeutic for age-related diseases.

Author(s): 
Collins, James J.
Evason, Kimberley
Pickett, Christopher L.
Schneider, Daniel L.
Kornfeld, Kerry
Publication Title: 
Experimental Gerontology

Severe mitochondria deficiency leads to a number of devastating degenerative disorders, yet, mild mitochondrial dysfunction in different species, including the nematode Caenorhabditis elegans, can have pro-longevity effects. This apparent paradox indicates that cellular adaptation to partial mitochondrial stress can induce beneficial responses, but how this is achieved is largely unknown. Complete absence of frataxin, the mitochondrial protein defective in patients with Friedreich's ataxia, is lethal in C.

Author(s): 
Schiavi, Alfonso
Torgovnick, Alessandro
Kell, Alison
Megalou, Evgenia
Castelein, Natascha
Guccini, Ilaria
Marzocchella, Laura
Gelino, Sara
Hansen, Malene
Malisan, Florence
CondÚ, Ivano
Bei, Roberto
Rea, Shane L.
Braeckman, Bart P.
Tavernarakis, Nektarios
Testi, Roberto
Ventura, Natascia
Publication Title: 
Experimental Gerontology

Severe mitochondria deficiency leads to a number of devastating degenerative disorders, yet, mild mitochondrial dysfunction in different species, including the nematode Caenorhabditis elegans, can have pro-longevity effects. This apparent paradox indicates that cellular adaptation to partial mitochondrial stress can induce beneficial responses, but how this is achieved is largely unknown. Complete absence of frataxin, the mitochondrial protein defective in patients with Friedreich's ataxia, is lethal in C.

Author(s): 
Schiavi, Alfonso
Torgovnick, Alessandro
Kell, Alison
Megalou, Evgenia
Castelein, Natascha
Guccini, Ilaria
Marzocchella, Laura
Gelino, Sara
Hansen, Malene
Malisan, Florence
CondÚ, Ivano
Bei, Roberto
Rea, Shane L.
Braeckman, Bart P.
Tavernarakis, Nektarios
Testi, Roberto
Ventura, Natascia
Publication Title: 
Journal of Dental Research

Odontoblasts are dentin-secreting cells that survive for the whole life of a healthy tooth. Once teeth are completely erupted, odontoblasts transform into a mature stage that allows for their functional conservation for decades, while maintaining the capacity for secondary and reactionary dentin secretion. Odontoblasts are also critically involved in the transmission of sensory stimuli from the dentin-pulp complex and in the cellular defense against pathogens. Their longevity is sustained by an elaborate autophagic-lysosomal system that ensures organelle and protein renewal.

Author(s): 
Couve, E.
Osorio, R.
Schmachtenberg, O.
Publication Title: 
Annual Review of Genetics

The molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between C. elegans and its microbial environment may influence the aging and longevity of this simple host organism.

Author(s): 
Kim, Dennis H.
Publication Title: 
The Spanish Journal of Psychology

The authors of the present article based their assumption on the concept that the sensory systems are the "windows to the brain" through which various functions of the human organism can be controlled. Comprehension of the fundamental mechanisms of the optimization of the sensory systems, brain, and cardiac functions has increased based on the prolonged sensory flows using conscious and unconscious aromatherapy and multimodal sensory activation.

Author(s): 
Bykov, Anatolij T.
Malyarenko, Tatyana N.
Malyarenko, Yurij E.
Terentjev, Vladimir P.
Dyuzhikov, Alexandr A.
Publication Title: 
Acta Clinica Croatica

Nasal mucosa is innervated by multiple subsets of nociceptive, parasympathetic and sympathetic nerves. These play carefully coordinated roles in regulating glandular, vascular and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs.

Author(s): 
Baraniuk, James N.
Merck, Samantha J.
Publication Title: 
Human Brain Mapping

The concept that specific acupuncture points have salubrious effects on distant target organ systems is a salient feature of Traditional Chinese Medicine (TCM). In this study, we used a multiple-session experiment to test whether electroacupuncture stimulation at two TCM vision-related acupoints, UB 60 and GB 37, located on the leg, could produce fMRI signal changes in the occipital regions of the brain, and the specificity of this effect when compared with stimulation at an adjacent non-acupoint (NAP). Six normal, acupuncture naive subjects completed the study.

Author(s): 
Kong, Jian
Kaptchuk, Ted J.
Webb, Julia Megan
Kong, Jiang-Ti
Sasaki, Yuka
Polich, Ginger R.
Vangel, Mark G.
Kwong, Kenneth
Rosen, Bruce
Gollub, Randy L.
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

Chronic fatigue syndrome (CFS) is characterized by debilitating fatigue, often accompanied by widespread muscle pain that meets criteria for fibromyalgia syndrome (FMS). Symptoms become markedly worse after exercise. Previous studies implicated dysregulation of the sympathetic nervous system (SNS), and immune system (IS) in CFS and FMS.

Author(s): 
Light, Alan R.
White, Andrea T.
Hughen, Ronald W.
Light, Kathleen C.
Publication Title: 
Cells, Tissues, Organs

Chronic musculoskeletal pain, including low back pain, is a worldwide debilitating condition; however, the mechanisms that underlie its development remain poorly understood. Pathological neuroplastic changes in the sensory innervation of connective tissue may contribute to the development of nonspecific chronic low back pain. Progress in understanding such potentially important abnormalities is hampered by limited knowledge of connective tissue's normal sensory innervation.

Author(s): 
Corey, Sarah M.
Vizzard, Margaret A.
Badger, Gary J.
Langevin, Helene M.

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