Skin Aging

Publication Title: 
Phytotherapy research: PTR

The ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK-N/F cells with 60.5 +/- 3.8% at a concentration of 50 microg/ml. In addition, the T. chebula extract exhibited a significant cytoprotective effect against UVB-induced oxidative damage.

Na, MinKyun
Bae, KiHwan
Kang, Sam Sik
Min, Byung Sun
Yoo, Jae Kuk
Kamiryo, Yuko
Senoo, Yu-ichiro
Yokoo, Seiichi
Miwa, Nobuhiko
Publication Title: 
Pharmaceutical Biology

CONTEXT: The Thai Lanna region has its own folklores and wisdoms in various fields such as traditional medicines. The galls of Terminalia chebula Retz. (Combretaceae) frequently appear in many Thai Lanna medicinal plant recipes for promoting longevity. OBJECTIVES: To investigate the in vitro anti-aging activities of the extracts from 15 plants including T. chebula gall selected from the Thai medicinal plant recipes that have been traditionally used for longevity.

Manosroi, Aranya
Jantrawut, Pensak
Akihisa, Toshihiro
Manosroi, Worapaka
Manosroi, Jiradej
Publication Title: 
Pharmaceutical Biology

CONTEXT: The galls of Terminalia chebula Retz. (Combretaceae) frequently appear in many Thai Lanna medicinal plant recipes for promotion of longevity. OBJECTIVE: The objective of this study was to evaluate the skin anti-aging of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from T. chebula galls. METHOD: The semi-purified fraction containing phenolic compounds including gallic acid isolated from T.

Manosroi, Aranya
Jantrawut, Pensak
Akihisa, Toshihiro
Manosroi, Worapaka
Manosroi, Jiradej
Publication Title: 
Oxidative Medicine and Cellular Longevity

The exposure to ultraviolet radiations (UVR) is the key source of skin sunburn; it may produce harmful entities, reactive oxygen species (ROS), leading to aging. The skin can be treated and protected from the injurious effects of ROS by using various pharmaceutical formulations, such as cream. Cream can be loaded with antioxidants to quench ROS leading to photo-protective effects. Moreover, modern medicines depend on ethnobotanicals for protection or treatment of human diseases. This review article summarizes various in vivo antioxidant studies on herbal creams loaded with phyto-extracts.

Jadoon, Saima
Karim, Sabiha
Bin Asad, Muhammad Hassham Hassan
Akram, Muhammad Rouf
Khan, Abida Kalsoom
Malik, Arif
Chen, Chunye
Murtaza, Ghulam
Publication Title: 
Aging Cell

Cellular senescence is a defense mechanism in response to molecular damage which accumulates with aging. Correspondingly, the number of senescent cells has been reported to be greater in older than in younger subjects and furthermore associates with age-related pathologies. Inter-individual differences exist in the rate at which a person ages (biological age). Here, we studied whether younger biological age is related to fewer senescent cells in middle-aged individuals with the propensity for longevity, using p16INK4a as a marker for cellular senescence.

Waaijer, MariÎtte E. C.
Parish, William E.
Strongitharm, Barbara H.
van Heemst, Diana
Slagboom, Pieternella E.
de Craen, Anton J. M.
Sedivy, John M.
Westendorp, Rudi G. J.
Gunn, David A.
Maier, Andrea B.
Publication Title: 
Human Molecular Genetics

The CISD2 gene, which is an evolutionarily conserved novel gene, encodes a transmembrane protein primarily associated with the mitochondrial outer membrane. Significantly, the CISD2 gene is located within the candidate region on chromosome 4q where a genetic component for human longevity has been mapped. Previously, we have shown that Cisd2 deficiency shortens lifespan resulting in premature aging in mice. Additionally, an age-dependent decrease in Cisd2 expression has been detected during normal aging.

Wu, Chia-Yu
Chen, Yi-Fan
Wang, Chih-Hao
Kao, Cheng-Heng
Zhuang, Hui-Wen
Chen, Chih-Cheng
Chen, Liang-Kung
Kirby, Ralph
Wei, Yau-Huei
Tsai, Shih-Feng
Tsai, Ting-Fen
Publication Title: 
The Journal of Investigative Dermatology

Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply 3'-end sequencing for expression quantification ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin aging (collectively termed "skin aging"), and the impact of broadband light (BBL) treatment.

Chang, Anne Lynn S.
Bitter, Patrick H.
Qu, Kun
Lin, Meihong
Rapicavoli, Nicole A.
Chang, Howard Y.
Publication Title: 
Archives of Dermatological Research

Sirtuins are a family of seven proteins in humans (SIRT1-SIRT7) that are involved in multiple cellular processes relevant to dermatology. The role of sirtuins in other organ systems is established. However, the importance of these proteins in dermatology is less defined. Recently, sirtuins gained international attention because of their role as "longevity proteins" that may extend and enhance human life.

Serravallo, Melissa
Jagdeo, Jared
Glick, Sharon A.
Siegel, Daniel M.
Brody, Neil I.
Publication Title: 
Journal of Cosmetic Dermatology

OBJECTIVES: To evaluate the effects of the aroma of essential oil of lavender against placebo on subjects' pain perceptions and levels of anxiety when undergoing elective cosmetic facial injections of botulinum toxin type A (BOTOX(�) COSMETIC) for the correction of glabellar wrinkles. METHODS: Subjects (N=30) who had not previously received any cosmetic facial injections were randomized to essential oil of lavender aroma exposure or to placebo during elective cosmetic facial injections of BOTOX(�) (12 U) for the correction of glabellar wrinkles.

Grunebaum, Lisa Danielle
Murdock, Jennifer
Castanedo-Tardan, Mari Paz
Baumann, Leslie S.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

Turmeric (the rhizomes of Curcuma longa L., Zingiberacease) is widely used as a dietary pigment and spice, and has been traditionally used for the treatment of inflammation, skin wounds and hepatic disorders in Ayurvedic, Unani and Chinese medicine. Although the topical application or oral administration of turmeric is used to improve skin trouble, there is no evidence to support this effect. The aim of this study was to clarify whether turmeric prevents chronic ultraviolet B (UVB)-irradiated skin damage.

Sumiyoshi, Maho
Kimura, Yoshiyuki


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