Smad4 Protein

Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: Pancreatic cancer is the fourth cause of death from cancer in the western world. Majority of patients present with advanced unresectable disease responding poorly to most chemotherapeutic agents. Chemotherapy for pancreatic cancer might be improved by adjusting it to individual genetic profiles. We attempt to identify genetic predictors of chemosensitivity to broad classes of anticancer drugs.

Author(s): 
Cui, Yunfeng
Brosnan, Jacqueline A.
Blackford, Amanda L.
Sur, Surojit
Hruban, Ralph H.
Kinzler, Kenneth W.
Vogelstein, Bert
Maitra, Anirban
Diaz, Luis A.
Iacobuzio-Donahue, Christine A.
Eshleman, James R.
Publication Title: 
The Journal of Biological Chemistry

Bone morphogenetic proteins (BMPs) belong to the TGF-beta superfamily and play an important role in development and in many cellular processes. We have found that BMP-2, BMP-6, and BMP-9 induce the most potent osteogenic differentiation of mesenchymal stem cells. Expression profiling analysis has revealed that the Inhibitors of DNA binding/differentiation (Id)-1, Id-2, and Id-3 are among the most significantly up-regulated genes upon BMP-2, BMP-6, or BMP-9 stimulation. Here, we sought to determine the functional role of these Id proteins in BMP-induced osteoblast differentiation.

Author(s): 
Peng, Ying
Kang, Quan
Luo, Qing
Jiang, Wei
Si, Weike
Liu, Bernard A.
Luu, Hue H.
Park, Jong Kyung
Li, Xinmin
Luo, Jeffrey
Montag, Anthony G.
Haydon, Rex C.
He, Tong-Chuan
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: Alterations in Smad4 signaling and its loss cause genomic instability and head and neck squamous cell carcinoma (HNSCC), suggesting that agents that target both Smad4-dependent and -independent pathways could control HNSCC. EXPERIMENTAL DESIGN: Resveratrol efficacy was evaluated against the HNSCC cells FaDu, Cal27, Det562, and Cal27-Smad4 for viability, DNA damage, cell-cycle progression, and apoptosis, as well as γ-H2AX expression, and focus formation (γ-H2AX and Brca1). Resveratrol efficacy was also examined in nude mice for FaDu xenograft growth.

Author(s): 
Tyagi, Alpna
Gu, Mallikarjuna
Takahata, Takenori
Frederick, Barbara
Agarwal, Chapla
Siriwardana, Sunitha
Agarwal, Rajesh
Sclafani, Robert A.
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