South Africa

Publication Title: 
BMC public health

BACKGROUND: Traditional medicine use has been reported is common among individuals with moderate and advanced HIV disease. The aim of this cross-sectional study was to assess the use of Traditional Complementary and Alternative Medicine (TCAM) for HIV patients prior to initiating antiretroviral therapy in three public hospitals in KwaZulu-Natal, South Africa. METHODS: Using systematic sampling, 618 HIV-positive patients were selected from outpatient departments from three hospitals and interviewed with a questionnaire.

Author(s): 
Peltzer, Karl
Preez, Natalie Friend-du
Ramlagan, Shandir
Fomundam, Henry
Publication Title: 
Journal of Religion and Health

The purpose of this qualitative study was to explore spirituality as a characteristic of family resilience in Xhosa-speaking families in South Africa. A parent, and in some cases an adolescent, represented each of the 51 families that participated. Participants were expected to respond to three open-ended questions regarding their family and identify factors or strengths that had recently helped their family. The results indicate that spirituality is an important coping resource.

Author(s): 
Greeff, Abraham P.
Loubser, Karla
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Adherence to antiretroviral medication in the treatment of HIV is critical, both to maximize efficacy and to minimize the emergence of drug resistance. The aim of this prospective study in three public hospitals in KwaZulu-Natal, South Africa, is to assess the use of Traditional Complementary and Alternative Medicine (TCAM) by HIV patients and its effect on antiretroviral (ARV) adherence 6 months after initiating ARVs.

Author(s): 
Peltzer, Karl
Friend-du Preez, Natalie
Ramlagan, Shandir
Fomundam, Henry
Anderson, Jane
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

The aim of this prospective study (20 months) was to assess HIV patients' use of Traditional, Complementary and Alternative Medicine (TCAM) and its effect on ARV adherence at three public hospitals in KwaZulu-Natal, South Africa. Seven hundred and thirty-five (29.8% male and 70.2% female) patients who consecutively attended three HIV clinics completed assessments prior to ARV initiation, 519 after 6 months, 557 after 12 and 499 after 20 months on antiretroviral therapy (ART).

Author(s): 
Peltzer, Karl
Preez, Natalie Friend-du
Ramlagan, Shandir
Fomundam, Henry
Anderson, Jane
Chanetsa, Lucia
Publication Title: 
AIDS care

Abstract Depressive symptoms are highly prevalent, underdiagnosed, and undertreated in people living with HIV/AIDS (PLWH), and are associated with poorer health outcomes. This randomized controlled trial examined the effects of the HIV/AIDS Symptom Management Manual self-care symptom management strategies compared with a nutrition manual on depressive symptoms in an international sample of PLWH. The sample consisted of a sub-group (N=222) of participants in a larger study symptom management study who reported depressive symptoms.

Author(s): 
Eller, Lucille S.
Kirksey, Kenn M.
Nicholas, Patrice K.
Corless, Inge B.
Holzemer, William L.
Wantland, Dean J.
Willard, Suzanne S.
Robinson, Linda
Hamilton, Mary Jane
Sefcik, Elizabeth F.
Moezzi, Shahnaz
Mendez, Marta Rivero
Rosa, Maria
Human, Sarie
Publication Title: 
Journal of Natural Products

Four new cycloartane glycosides, sutherlandiosides A-D (1-4), were isolated from the South African folk medicine Sutherlandia frutescens and their structures established by spectroscopic methods and X-ray crystallography as 1 S,3 R,24S,25-tetrahydroxy-7S,10S-epoxy-9,10- seco-9,19-cyclolanost-9(11)-ene 25-O-beta-D-glucopyranoside (1), 3R,7S,24S,25-tetrahydroxycycloartan-1-one 25-O-beta-D-glucopyranoside (2), 3R,24S,25-trihydroxycycloartane-1,11-dione 25-O-beta-D-glucopyranoside (3), and 7S,24S,25-trihydroxycycloart-2-en-1-one 25-O-beta-D-glucoyranoside (4).

Author(s): 
Fu, Xiang
Li, Xing-Cong
Smillie, Troy J.
Carvalho, Paulo
Mabusela, Wilfred
Syce, James
Johnson, Quinton
Folk, William
Avery, Mitchell A.
Khan, Ikhlas A.
Publication Title: 
Seminars in Nephrology

Before the era of highly active antiretroviral therapy, more than 40% of human immunodeficiency virus (HIV)-infected children experienced renal complications. In sub-Saharan Africa, approximately 2.1 million children are infected with HIV-1. In the absence of antiretroviral therapy, young African children frequently died of AIDS-related complications before renal diseases could be manifested or diagnosed. As antiretroviral therapy has become more available, and their survival has increased, our experience in treating kidney disease in HIV-infected children has improved.

Author(s): 
McCulloch, Mignon I.
Ray, Patricio E.
Publication Title: 
Journal of Acquired Immune Deficiency Syndromes (1999)

BACKGROUND: Drug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell entry, either as a consequence of natural viral evolution or HAART use, may compromise the efficacy of CCR5 antagonists as alternative antiviral therapy. METHODS: We sequenced the pol gene of viruses from 45 individuals failing at least 6 months of HAART in Durban, South Africa, to determine the prevalence and patterns of drug-resistance mutations.

Author(s): 
Singh, Ashika
Sunpath, Henry
Green, Taryn N.
Padayachi, Nagavelli
Hiramen, Keshni
Lie, Yolanda
Anton, Elizabeth D.
Murphy, Richard
Reeves, Jacqueline D.
Kuritzkes, Daniel R.
Ndung'u, Thumbi
Publication Title: 
AIDS research and human retroviruses

HIV-1 drug resistance monitoring in resource-poor settings is crucial due to limited drug alternatives. Recent reports of the increased prevalence of CXCR4 usage in subtype C infections may have implications for CCR5 antagonists in therapy. We investigated the prevalence of drug resistance mutations and CXCR4 coreceptor utilization of viruses from HIV-1 subtype C-infected children. Fifty-one children with virological failure during highly active antiretroviral therapy (HAART) and 43 HAART-naive children were recruited.

Author(s): 
Green, Taryn N.
Archary, Mohendran
Gordon, Michelle L.
Padayachi, Nagavelli
Lie, Yolanda
Anton, Elizabeth D.
Reeves, Jacqueline D.
Grobler, Anneke
Bobat, Raziya
Coovadia, Hoosen
Ndung'u, Thumbi
Publication Title: 
African journal of traditional, complementary, and alternative medicines: AJTCAM / African Networks on Ethnomedicines

Previous studies have reported that majority of antiretroviral (ARV) treatment-naïve patients use traditional medicine (TM). Given that TM use is ubiquitous in South Africa especially for chronic conditions, there is a potential for ARV non-adherence and serious drug interactions among patients with HIV/AIDs who use TM. The motivating factors for TM use in HIV/AIDS patients on ARV and prophylaxis treatment have not been well defined in South Africa.

Author(s): 
Hughes, G. D.
Puoane, T. R.
Clark, B. L.
Wondwossen, T. L.
Johnson, Q.
Folk, W.

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