Spectrophotometry, Ultraviolet

Publication Title: 
Phytochemical analysis: PCA

Triphala is an anti-oxidant-rich herbal formulation containing fruits of Emblica officinalis, Terminalia chebula and T. belerica in equal proportions. The preparation is frequently used in Ayurvedic medicine to treat diseases such as anaemia, jaundice, constipation, asthma, fever and chronic ulcers. Anti-mutagenic effects of the polyphenolic fractions isolated from Triphala have been reported, thus indicating that the phenols present in the formulation might be responsible for its therapeutic efficacy.

Author(s): 
Singh, D. P.
Govindarajan, R.
Rawat, A. K. S.
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

Biologically inspired experimental process in synthesising nanoparticles is of great interest in present scenario. Biosynthesis of nanoparticles is considered to be one of the best green techniques in synthesising metal nanoparticles. Here, an in situ green biogenic synthesis of gold nanoparticles using aqueous extracts of Terminalia chebula as reducing and stabilizing agent is reported. Gold nanoparticles were confirmed by surface plasmon resonance in the range of 535 nm using UV-visible spectrometry.

Author(s): 
Kumar, Kesarla Mohan
Mandal, Badal Kumar
Sinha, Madhulika
Krishnakumar, Varadhan
Publication Title: 
Planta Medica

Terminalia species are a rich source of tannins. Many preparations of these species are used in traditional medicine and have many different ethnobotanical applications. A simple UHPLC method was developed for the simultaneous analysis of such hydrolysable tannins and triterpene saponins from the fruit rinds of different species of Terminalia (T. chebula, T. arjuna, T. bellirica) and Phyllantus emblica. A separation by LC was achieved using a reversed-phase column and a water/acetonitrile mobile phase, both containing formic acid, using a gradient system and a temperature of 40°C.

Author(s): 
Avula, Bharathi
Wang, Yan-Hong
Wang, Mei
Shen, Yun-Heng
Khan, Ikhlas A.
Publication Title: 
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy

A green one step facile synthesis of graphene nanosheets by Terminalia chebula (T. chebula) extract mediated reduction of graphite oxide (GO) is reported in this work. This method avoids the use of harmful toxic reducing agents. The comparative results of various characterizations of GO and T. chebula reduced graphene oxide (TCG) provide a strong indication of the exclusion of oxygen containing groups from graphene oxide and successive stabilization of the formed reduced graphene oxide (RGO).

Author(s): 
Maddinedi, Sireesh Babu
Mandal, Badal Kumar
Vankayala, Raviraj
Kalluru, Poliraju
Pamanji, Sreedhara Reddy
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Telomerase is a ribonucleoprotein (RNP) required for maintenance of telomeres. Although up-regulated telomerase activity is closely linked to the cellular immortality characteristic of late stage carcinogenesis, recently, mutations in the telomerase RNA gene in humans have been associated with dyskeratosis congenita and aplastic anemia, both typified by impaired haemopoietic function. These mutations include base changes in a highly conserved putative telomerase RNA pseudoknot.

Author(s): 
Comolli, Luis R.
Smirnov, Ivan
Xu, Lifeng
Blackburn, Elizabeth H.
James, Thomas L.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Ro 42-1611 (arteflene) is a synthetic endoperoxide antimalarial. The antimalarial activity of endoperoxides is attributed to iron(II)-mediated generation of carbon-centered radicals. An alpha, beta-unsaturated ketone (enone; 4-[2',4' bis(trifluoromethyl)phenyl]-3-buten-2-one), obtained from arteflene by reaction with iron(II), was identified previously as the stable product of a reaction that, by inference, also yields a cyclohexyl radical. The activation of arteflene in vivo has been characterized with particular reference to enone formation.

Author(s): 
Bishop, L. P.
Maggs, J. L.
O'Neill, P. M.
Park, B. K.
Publication Title: 
Antimicrobial Agents and Chemotherapy

The immediate efficacies of two oral dosage regimens of artemisinin were investigated in 77 male and female adult Vietnamese falciparum malaria patients randomly assigned to treatment with either 500 mg of artemisinin daily for 5 days (group A; n = 40) or artemisinin at a dose of 100 mg per day for 2 days, with the dose increased to 250 mg per day for 2 consecutive days and with a final dose of 500 mg on the fifth day (group B; n = 37). Parasitemia was monitored every 4 h.

Author(s): 
Gordi, Toufigh
Huong, Dinh Xuan
Hai, Trinh Ngoc
Nieu, Nguyen Thi
Ashton, Michael
Publication Title: 
Antimicrobial Agents and Chemotherapy

Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

Author(s): 
Newton, Paul N.
van Vugt, Michèle
Teja-Isavadharm, Paktiya
Siriyanonda, Duangsuda
Rasameesoroj, Maneerat
Teerapong, Pramote
Ruangveerayuth, Ronatrai
Slight, Thra
Nosten, François
Suputtamongkol, Yupin
Looareesuwan, Sornchai
White, Nicholas J.
Publication Title: 
Antimicrobial Agents and Chemotherapy

The effect of mefloquine on artesunate pharmacokinetics was assessed in 20 volunteers given artesunate for 3 days, followed > or =21 days later by combination therapy for 3 days. The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction.

Author(s): 
Davis, Timothy M. E.
England, Michelle
Dunlop, Anne-Marie
Page-Sharp, Madhu
Cambon, Nathalie
Keller, Thomas G.
Heidecker, János L.
Ilett, Kenneth F.
Publication Title: 
Journal of Vector Borne Diseases

BACKGROUND & OBJECTIVES: Resistance to conventional antimalarials triggered off new policies to circumvent the devastating consequences of malaria especially in the trans-Saharan Africa. The use of artemisinin-based combinations as first line drug in treatment of uncomplicated malaria was then advocated and adopted by the World Health Organization (WHO). In Nigeria, this new policy has witnessed a surge in the number of circulating brands of such combinations.

Author(s): 
Esimone, C. O.
Omeje, E. O.
Okoye, F. B. C.
Obonga, W. O.
Onah, B. U.

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