Publication Title: 
Reproductive Toxicology (Elmsford, N.Y.)

Our interest in development of hyaluronidase inhibitors as male antifertility agents led to identification of Terminalia chebula (T. chebula) plant with hyaluronidase (HAase) inhibitory activity of human spermatozoa ( approximately 93% inhibition) and rat caudal epididymal spermatozoa ( approximately 86% inhibition) in vitro at 30 mg/ml.

Srivastav, Archana
Chandra, Abhishek
Singh, Madhulika
Jamal, Farrukh
Rastogi, Preeti
Rajendran, Siron Mani
Bansode, Falgun Wanganuji
Lakshmi, Vijai
Publication Title: 
Mutation Research

Sperm DNA fragmentation (SDF) is not a static seminal parameter, since the longevity of sperm DNA decreases progressively with time following ejaculation or thawing. While the dynamics of SDF is a species-specific characteristic, in the case of humans, there is still significant variation within patients.

Santiso, Rebeca
Tamayo, MarÌa
Gos·lvez, Jaime
Johnston, Steve
MariÒo, Alfonso
Fern·ndez, Carlos
Losada, Carlos
Fern·ndez, JosÈ Luis
Publication Title: 
Journal of Assisted Reproduction and Genetics

PURPOSE: To study the effect of supplementing biotin to sperm preparation medium on the motility of frozen-thawed spermatozoa. METHODS: Semen samples of men attending the University infertility clinic (n?=?105) were cryopreserved using glycerol-egg yolk-citrate buffered cryoprotective medium in liquid nitrogen. After a period of two weeks, the semen samples were thawed and the motile spermatozoa were extracted by swim-up technique using Earle's balanced salt solution (EBSS) medium supplemented with either biotin (10 nM) or pentoxifylline (1 mM).

Kalthur, Guruprasad
Salian, Sujith R.
Keyvanifard, Farid
Sreedharan, Shyam
Thomas, Jeena S.
Kumar, Pratap
Adiga, Satish K.
Publication Title: 
Molecular Psychiatry

Epigenetic studies of DNA and histone modifications represent a new and important activity in molecular investigations of human disease. Our previous epigenome-wide scan identified numerous DNA methylation differences in post-mortem brain samples from individuals affected with major psychosis. In this article, we present the results of fine mapping DNA methylation differences at the human leukocyte antigen (HLA) complex group 9 gene (HCG9) in bipolar disorder (BPD).

Kaminsky, Z.
Tochigi, M.
Jia, P.
Pal, M.
Mill, J.
Kwan, A.
Ioshikhes, I.
Vincent, J. B.
Kennedy, J. L.
Strauss, J.
Pai, S.
Wang, S.-C.
Petronis, A.
Publication Title: 
Journal of Opioid Management

OBJECTIVE: The OPRM1 gene was studied for DNA methylation in opioid dependence and possible paternal contribution to epigenetic inheritance of altered methylation profiles. PARTICIPANTS AND METHODS: DNA was extracted from blood and sperm from 13 male opioid addicts and 21 male control subjects. DNA methylation was determined by pyrosequencing in 24 CpG sites at the OPRM1 promoter region. RESULTS: The authors found significantly increased overall methylation in blood DNA from addicted subjects (Kruskal-Wallis [K-W] p = 0.013).

Chorbov, Vesselin M.
Todorov, Alexandre A.
Lynskey, Michael T.
Cicero, Theodore J.
Publication Title: 
Biological Psychiatry

BACKGROUND: Major depressive disorder (MDD) exhibits numerous clinical and molecular features that are consistent with putative epigenetic misregulation. Despite growing interest in epigenetic studies of psychiatric diseases, the methodologies guiding such studies have not been well defined. METHODS: We performed DNA modification analysis in white blood cells from monozygotic twins discordant for MDD, in brain prefrontal cortex, and germline (sperm) samples from affected individuals and control subjects (total N = 304) using 8.1K CpG island microarrays and fine mapping.

Oh, Gabriel
Wang, Sun-Chong
Pal, Mrinal
Chen, Zheng Fei
Khare, Tarang
Tochigi, Mamoru
Ng, Catherine
Yang, Yeqing A.
Kwan, Andrew
Kaminsky, Zachary A.
Mill, Jonathan
Gunasinghe, Cerisse
Tackett, Jennifer L.
Gottesman, Irving I.
Willemsen, Gonneke
de Geus, Eco J. C.
Vink, Jacqueline M.
Slagboom, P. Eline
Wray, Naomi R.
Heath, Andrew C.
Montgomery, Grant W.
Turecki, Gustavo
Martin, Nicholas G.
Boomsma, Dorret I.
McGuffin, Peter
Kustra, Rafal
Petronis, Art
Publication Title: 
International Journal of Epidemiology

BACKGROUND: Epigenetic mechanisms such as altered DNA methylation have been suggested to play a role in autism, beginning with the classical association of Prader-Willi syndrome, an imprinting disorder, with autistic features. OBJECTIVES: Here we tested for the relationship of paternal sperm DNA methylation with autism risk in offspring, examining an enriched-risk cohort of fathers of autistic children.

Feinberg, Jason I.
Bakulski, Kelly M.
Jaffe, Andrew E.
Tryggvadottir, Rakel
Brown, Shannon C.
Goldman, Lynn R.
Croen, Lisa A.
Hertz-Picciotto, Irva
Newschaffer, Craig J.
Fallin, M. Daniele
Feinberg, Andrew P.
Publication Title: 
Journal of Medical Ethics

There has been a troublesome anomaly in the UK between cash payment to men for sperm donation and the effective assumption that women will pay to donate eggs. Some commentators, including Donald Evans in this journal, have argued that the anomaly should be resolved by treating women on the same terms as men. But this argument ignores important difficulties about property in the body, particularly in relation to gametes.

Dickenson, D. L.
Publication Title: 
Asian Journal of Andrology

Sperm donation in China is different from that in other countries due to cultural, social and political factors. This research presents the current status of sperm donation in Mainland China and highlights some problems. Between January 2003 and December 2009, 19 471 sperm donors were screened totally and 6467 donors (33.2%) were recruited. The primary reasons for non-recruitment were either inadequate semen parameters (55.0%) or positive results for sexually transmitted diseases (7.9%).

Ping, Ping
Zhu, Wen-Bing
Zhang, Xin-Zong
Li, Yu-Shan
Wang, Quan-Xian
Cao, Xiao-Rong
Liu, Yong
Dai, Hui-Li
Huang, Yi-Ran
Li, Zheng
Publication Title: 
Human Reproduction Update

BACKGROUND This systematic review aimed first to integrate the current body of knowledge on the demographic, institutional and psychosocial information on sperm donors, and second to provide insight into the actual experiences of men who donate and the attitudes towards potential donation. METHODS Electronic databases (PUBMED, CINAHL, PsycINFO, Embase and Web of Science) were searched with no date restriction using a specific search strategy followed by a snowball strategy.

Van den Broeck, U.
Vandermeeren, M.
Vanderschueren, D.
Enzlin, P.
Demyttenaere, K.
D'Hooghe, T.


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