Splenomegaly

Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Many countries in Africa, including Sierra Leone, have adopted artemisinin-based combination therapy as first-line therapy for treatment of patients with malaria. Because laboratory testing is often unavailable in rural areas, the cost-benefit and viability of this approach may depend on accurately diagnosing malaria by using clinical criteria. We assessed the accuracy of syndromic diagnosis for malaria in three peripheral health units in rural Sierra Leone and determined factors that were associated with an accurate malaria diagnosis.

Author(s): 
Nnedu, Obinna N.
Rimel, Bryan
Terry, Carey
Jalloh-Vos, Heidi
Baryon, Brima
Bausch, Daniel G.
Publication Title: 
Digestive Diseases and Sciences

The multifunctional pattern recognition scavenger receptors, SR-A and CD36, are predominantly expressed by lamina propria macrophages and considered important in innate immunity. We examined the role of these receptors in the pathophysiology of inflammatory bowel disease. Colitis was induced in wild type (WT), SRA(-/-), CD36(-/-), and SR-A/CD36 double deficient mice by administering DSS. DSS-induced moderately severe colitis in WT mice was manifested by weight loss, reduced hematocrit, and pathology.

Author(s): 
Oz, Helieh S.
Zhong, Jian
de Villiers, Willem J. S.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Allogeneic hematopoietic cell transplantation (HCT) is widely used to treat patients with life-threatening malignant and nonmalignant hematological diseases. However, allogeneic HCT often is accompanied by severe and lethal complications from graft-versus-host disease (GVHD), in which activated donor T cells recognize histocompatibility antigenic mismatches and cause significant toxicity in the recipient. In the current study, we tested the hypothesis that activation of cannabinoid receptors on donor-derived T cells may prevent GVHD.

Author(s): 
Pandey, Rupal
Hegde, Venkatesh L.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Publication Title: 
Blood

Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells. We show here that Δ(12)-PGJ(3), a novel and naturally produced CyPG from the dietary fish-oil ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA; 20:5) alleviates the development of leukemia in 2 well-studied murine models of leukemia.

Author(s): 
Hegde, Shailaja
Kaushal, Naveen
Ravindra, Kodihalli C.
Chiaro, Christopher
Hafer, Kelsey T.
Gandhi, Ujjawal H.
Thompson, Jerry T.
van den Heuvel, John P.
Kennett, Mary J.
Hankey, Pamela
Paulson, Robert F.
Prabhu, K. Sandeep
Publication Title: 
American Journal of Physiology. Gastrointestinal and Liver Physiology

Dietary iron is particularly critical during periods of rapid growth such as in neonatal development. Human and rodent studies have indicated that iron deficiency or excess during this critical stage of development can have significant long- and short-term consequences. Since the requirement for iron changes during development, the availability of adequate iron is critical for the differentiation and maturation of individual organs participating in iron homeostasis.

Author(s): 
Hegde, Narasimha V.
Unger, Erica L.
Jensen, Gordon L.
Hankey, Pamela A.
Paulson, Robert F.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the clinical features of primary biliary cirrhosis (PBC) and its treatment by integrated traditional Chinese and western medicine. METHODS: 16 PBC patients were observed. Ursodeoxycholic acid (UDCA) was used in the dose of 13 to 15 mg.kg(-1).d(-1), with some traditional Chinese herb prescription. Results (1) The proportion of women to men was 15:1, the mean age was 52.5 years. AMA-M2 was positive in 14 subjects (87.5%). Biliary tract enzymes and ESR were elevated in all subjects. The ratio of hypercholesterolemia (CHOL) and abnormality in IgM was high (62.5%).

Author(s): 
Jiang, Jian
He, Miao
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