Stem Cell Factor

Publication Title: 
Cell Reports

Intermittent fasting is one of the most effective dietary restriction regimens that extend life span in C. elegans and mammals. Fasting-stimulus responses are key to the longevity response; however, the mechanisms that sense and transduce the fasting stimulus remain largely unknown. Through a comprehensive transcriptome analysis in C. elegans, we find that along with the FOXO transcription factor DAF-16, AP-1 (JUN-1/FOS-1) plays a central role in fasting-induced transcriptional changes. KGB-1, one of the C. elegans JNKs, acts as an activator of AP-1 and is activated in response to fasting.

Author(s): 
Uno, Masaharu
Honjoh, Sakiko
Matsuda, Mitsuhiro
Hoshikawa, Haruka
Kishimoto, Saya
Yamamoto, Tomohito
Ebisuya, Miki
Yamamoto, Takuya
Matsumoto, Kunihiro
Nishida, Eisuke
Publication Title: 
Nature Communications

DNA methylation likely plays a role in the regulation of human stress reactivity. Here we show that in a genome-wide analysis of blood DNA methylation in 85 healthy individuals, a locus in the Kit ligand gene (KITLG; cg27512205) showed the strongest association with cortisol stress reactivity (P=5.8 ◊ 10(-6)). Replication was obtained in two independent samples using either blood (N=45, P=0.001) or buccal cells (N=255, P=0.004). KITLG methylation strongly mediates the relationship between childhood trauma and cortisol stress reactivity in the discovery sample (32% mediation).

Author(s): 
Houtepen, Lotte C.
Vinkers, Christiaan H.
Carrillo-Roa, Tania
Hiemstra, Marieke
van Lier, Pol A.
Meeus, Wim
Branje, Susan
Heim, Christine M.
Nemeroff, Charles B.
Mill, Jonathan
Schalkwyk, Leonard C.
Creyghton, Menno P.
Kahn, RenÈ S.
JoÎls, Marian
Binder, Elisabeth B.
Boks, Marco P. M.
Publication Title: 
Blood

CD34+ precursors in normal human bone marrow (BM) generate large numbers of dendritic cells alongside macrophages and granulocytic precursors when cultured for 12 to 14 days in c-kit ligand, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-alpha (TNF-alpha). This study reports an intermediate cell type that develops by day 6, and has the potential to differentiate into either macrophages or dendritic cells.

Author(s): 
Szabolcs, P.
Avigan, D.
Gezelter, S.
Ciocon, D. H.
Moore, M. A.
Steinman, R. M.
Young, J. W.
Publication Title: 
The American Journal of Cardiology

Endothelial progenitor cells (EPCs) are an emerging biomarker of vascular health. However, there are few data on the biology and mobilizing factors of EPCs in metabolic syndrome (MS). The aim of this study was to assay EPC mobilizing factors, including granulocyte colony-stimulating factor, stem cell factor/c-kit ligand (SCF), vascular endothelial growth factor, and stromal cell-derived factor-1 levels, in patients with MS (n = 36) and age- and gender-matched controls (n = 38). There was a significant reduction of 83% in granulocyte colony-stimulating factor levels in patients with MS.

Author(s): 
Jialal, Ishwarlal
Fadini, Gian Paolo
Pollock, Kari
Devaraj, Sridevi
Publication Title: 
Cell Reports

Intermittent fasting is one of the most effective dietary restriction regimens that extend life span in C. elegans and mammals. Fasting-stimulus responses are key to the longevity response; however, the mechanisms that sense and transduce the fasting stimulus remain largely unknown. Through a comprehensive transcriptome analysis in C. elegans, we find that along with the FOXO transcription factor DAF-16, AP-1 (JUN-1/FOS-1) plays a central role in fasting-induced transcriptional changes. KGB-1, one of the C. elegans JNKs, acts as an activator of AP-1 and is activated in response to fasting.

Author(s): 
Uno, Masaharu
Honjoh, Sakiko
Matsuda, Mitsuhiro
Hoshikawa, Haruka
Kishimoto, Saya
Yamamoto, Tomohito
Ebisuya, Miki
Yamamoto, Takuya
Matsumoto, Kunihiro
Nishida, Eisuke
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