Stomach Neoplasms

Publication Title: 
Journal of experimental & clinical cancer research: CR

The present work is probably the first report on cancer chemopreventive potential of Triphala, a combination of fruit powder of three different plants namely Terminalia chebula, Terminalia belerica and Emblica officinalis. Triphala is a popular formulation of the Ayurvedic system of medicine. Our findings have shown that Triphala in diet has significantly reduced the benzo(a)pyrene [B(a)P] induced forestomach papillomagenesis in mice. In the short term treatment groups, the tumor incidences were lowered to 77.77% by both doses of Triphala mixed diet.

Author(s): 
Deep, G.
Dhiman, M.
Rao, A. R.
Kale, R. K.
Publication Title: 
Basic & Clinical Pharmacology & Toxicology

Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively.

Author(s): 
Kim, Byung J.
Nam, Joo H.
Kwon, Young K.
So, Insuk
Kim, Seon J.
Publication Title: 
International Journal of Cancer. Journal International Du Cancer
Author(s): 
Blackburn, E. K.
Callender, S. T.
Dacie, J. V.
Doll, R.
Girdwood, R. H.
Mollin, D. L.
Saracci, R.
Stafford, J. L.
Thompson, R. B.
Varadi, S.
Wetherley-Mein, G.
Publication Title: 
Voprosy Onkologii

The study group included 21 patients with malignant melanoma stage II-IV, aged 25-67, and 25 patients, aged 28-68, (control) with stomach tumors stage I-IV. All patients received individually-tailored hypnosis. Our newly-developed methods used batteries of suggestive images to deal with non-psychotic disorders and to map out strategies to support immunocompromised patients. In group 1, suggestion stimulated the "devouring" effect of the "patroling" cells.

Author(s): 
Bukhtoiarov, O. V.
Kozhevnikov, V. S.
Samarin, D. M.
Solov'ëva, I. G.
Pronkina, N. V.
Shishikova, I. V.
Kozlov, V. A.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

The cytotoxicities of 2 derivatives of artemisinin B and 2 derivatives of artemisic acid (designated as Compound A, B, C, and D) were investigated, using trypan blue dye exclusion test and colony-forming units assay. At the concentration of 5 micrograms.ml-1, the inhibition rates of these 4 compounds against murine leukemia cell line P388 were > 85%.

Author(s): 
Sun, W. C.
Han, J. X.
Yang, W. Y.
Deng, D. A.
Yue, X. F.
Publication Title: 
Acta Biochimica Et Biophysica Sinica

The inhibition effects of tea theaflavins complex (TFs), theaflavin-3-3'-digallate (TFDG), theaflavin-3'-gallate (TF2B), and an unidentified compound (UC) on the growth of human liver cancer BEL-7402 cells, gastric cancer MKN-28 cells and acute promyelocytic leukemia LH-60 cells were investigated. TFs was obtained through the catalysis of catechins with immobilized polyphenols oxidase. TFDG, TF2B and UC were isolated from TFs with high speed countercurrent chromatography (HSCCC).

Author(s): 
Tu, You-ying
Tang, An-Bin
Watanabe, Naoharu
Publication Title: 
Journal of experimental & clinical cancer research: CR

The present work is probably the first report on cancer chemopreventive potential of Triphala, a combination of fruit powder of three different plants namely Terminalia chebula, Terminalia belerica and Emblica officinalis. Triphala is a popular formulation of the Ayurvedic system of medicine. Our findings have shown that Triphala in diet has significantly reduced the benzo(a)pyrene [B(a)P] induced forestomach papillomagenesis in mice. In the short term treatment groups, the tumor incidences were lowered to 77.77% by both doses of Triphala mixed diet.

Author(s): 
Deep, G.
Dhiman, M.
Rao, A. R.
Kale, R. K.
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

The purpose of our study was to examine the roles of green tea drinking, other risk and protective factors, and polymorphism of susceptibility genes such as GSTM1, GSTT1, GSTP1, and p53 codon 72 and their possible joint effects on the risk of stomach cancer. A population-based case-control study was conducted in Taixing, China, including 206 newly diagnosed cases with stomach cancer and 415 healthy control subjects. Epidemiological data were collected by in-person interviews using a standard questionnaire. Polymorphisms of susceptibility genes were assayed by PCR-RFLP techniques.

Author(s): 
Mu, Li-Na
Lu, Qing-Yi
Yu, Shun-Zhang
Jiang, Qing-Wu
Cao, Wei
You, Nai-Chieh
Setiawan, Veronica Wendy
Zhou, Xue-Fu
Ding, Bao-Guo
Wang, Ru-Hong
Zhao, Jinkou
Cai, Lin
Rao, Jian-Yu
Heber, David
Zhang, Zuo-Feng
Publication Title: 
Cancer Research

Diphenyl difluoroketone (EF24), a molecule having structural similarity to curcumin, was reported to inhibit proliferation of a variety of cancer cells in vitro. However, the efficacy and in vivo mechanism of action of EF24 in gastrointestinal cancer cells have not been investigated. Here, we assessed the in vivo therapeutic effects of EF24 on colon cancer cells. Using hexosaminidase assay, we determined that EF24 inhibits proliferation of HCT-116 and HT-29 colon and AGS gastric adenocarcinoma cells but not of mouse embryo fibroblasts.

Author(s): 
Subramaniam, Dharmalingam
May, Randal
Sureban, Sripathi M.
Lee, Katherine B.
George, Robert
Kuppusamy, Periannan
Ramanujam, Rama P.
Hideg, Kalman
Dieckgraefe, Brian K.
Houchen, Courtney W.
Anant, Shrikant
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Gene promoter CpG island hypermethylation is associated with Helicobacter pylori (H. pylori) infection and may be an important initiator of gastric carcinogenesis. To examine factors influencing methylation, we utilized bisulfite Pyrosequencing® technology for quantitative analysis of promoter DNA methylation in RPRM, APC, MGMT and TWIST1 genes using DNA from 86 gastric biopsies from Colombian residents of areas with high and low incidence of gastric cancer. H. pylori colonies were cultured from the same subjects, and gastric pathology was evaluated.

Author(s): 
Schneider, Barbara G.
Peng, Dun-Fa
Camargo, M. Constanza
Piazuelo, M. Blanca
Sicinschi, Liviu A.
Mera, Robertino
Romero-Gallo, Judith
Delgado, Alberto G.
Bravo, Luis E.
Wilson, Keith T.
Peek, Richard M.
Correa, Pelayo
El-Rifai, Wael

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