Stress, Mechanical

Publication Title: 
Surgical and radiologic anatomy: SRA

The use of Fuji films is simple but their manipulation and result interpretation seem to be difficult in the framework of medical research. The reliability and reproducibility of Fuji films have been proved by many previous studies. This study was undertaken to know precisely the articular zones of the elbow and to determine the compressive stress these areas undergo during different activities, in order to assess the importance of different articular contact areas.

Author(s): 
Chantelot, C.
Wavreille, G.
Dos Remedios, C.
Landejerit, B.
Fontaine, C.
Hildebrand, H.
Publication Title: 
FASEB journal: official publication of the Federation of American Societies for Experimental Biology

The mechanism of action of acupuncture remains largely unknown. The reaction to acupuncture needling known as 'de qi', widely viewed as essential to the therapeutic effect of acupuncture, may be a key to understanding its mechanism of action. De qi includes a characteristic needling sensation, perceived by the patient, and 'needle grasp' perceived by the acupuncturist. During needle grasp, the acupuncturist feels pulling and increased resistance to further movement of the inserted needle.

Author(s): 
Langevin, H. M.
Churchill, D. L.
Cipolla, M. J.
Publication Title: 
American Journal of Physiology. Cell Physiology

Cytoskeleton-dependent changes in cell shape are well-established factors regulating a wide range of cellular functions including signal transduction, gene expression, and matrix adhesion. Although the importance of mechanical forces on cell shape and function is well established in cultured cells, very little is known about these effects in whole tissues or in vivo. In this study we used ex vivo and in vivo models to investigate the effect of tissue stretch on mouse subcutaneous tissue fibroblast morphology.

Author(s): 
Langevin, Helene M.
Bouffard, Nicole A.
Badger, Gary J.
Iatridis, James C.
Howe, Alan K.
Publication Title: 
Arthritis and Rheumatism

OBJECTIVE: The mechanisms by which chondrocytes convert biomechanical signals into intracellular biochemical events are not well understood. In this study, we sought to determine the intracellular mechanisms of the magnitude-dependent actions of mechanical signals. METHODS: Chondrocytes isolated from rabbit articular cartilage were grown on flexible membranes. Cells were subjected to cyclic tensile strain (CTS) of various magnitudes in the presence or absence of interleukin-1beta (IL-1beta), which was used as a proinflammatory signal for designated time intervals.

Author(s): 
Agarwal, Sudha
Deschner, James
Long, Ping
Verma, Anupam
Hofman, Cynthia
Evans, Christopher H.
Piesco, Nicholas
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVES: To evaluate the proposed manual placebo in terms of success in blinding patients to treatment group assignment and outcomes between the treatment groups. DESIGN: Randomized controlled trial. SETTING: A chiropractic college research clinic in the midwestern United States. SUBJECTS: One hundred and eleven (111) individuals aged 18 years and over with subacute or chronic lowback pain.

Author(s): 
Hawk, Cheryl
Long, Cynthia R.
Rowell, Robert M.
Gudavalli, M. Ram
Jedlicka, James
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

The antiatherogenic effects of soy isoflavone consumption have been demonstrated in a variety of studies. However, the mechanisms involved remain poorly defined. Adhesion of monocytes to vascular endothelial cells is a key step within the inflammatory cascade that leads to atherogenesis. Many factors, including the physical forces associated with blood flow, regulate this process.

Author(s): 
Chacko, Balu K.
Chandler, Robert T.
Mundhekar, Ameya
Khoo, Nicholas
Pruitt, Heather M.
Kucik, Dennis F.
Parks, Dale A.
Kevil, Christopher G.
Barnes, Stephen
Patel, Rakesh P.
Publication Title: 
Annals of Biomedical Engineering

There is a high incidence of low back pain (LBP) associated with occupations requiring sustained and/or repetitive lumbar flexion (SLF and RLF, respectively), which cause creep of the viscoelastic tissues. The purpose of this study was to determine the effect of creep on lumbar biomechanics and facet joint capsule (FJC) strain. Specimens were flexed for 10 cycles, to a maximum 10 Nm moment at L5-S1, before, immediately after, and 20 min after a 20-min sustained flexion at the same moment magnitude.

Author(s): 
Little, Jesse S.
Khalsa, Partap S.
Publication Title: 
Journal of Biomechanical Engineering

The human facet joint capsule is one of the structures in the lumbar spine that constrains motions of vertebrae during global spine loading (e.g., physiological flexion). Computational models of the spine have not been able to include accurate nonlinear and viscoelastic material properties, as they have not previously been measured. Capsules were tested using a uniaxial ramp-hold protocol or a haversine displacement protocol using a commercially available materials testing device. Plane strain was measured optically.

Author(s): 
Little, Jesse S.
Khalsa, Partap S.
Publication Title: 
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society

OBJECTIVE: We sought to determine the molecular basis for the anticatabolic effects of mechanical signals on fibrocartilage cells by studying the expression of a variety of matrix metalloproteinases (MMPs). Furthermore, we examined whether the effects of biomechanical strain on MMP gene expression are sustained. METHODS: Fibrochondrocytes from temporomandibular joint (TMJ) discs were exposed to dynamic tensile strain for various time intervals in the presence of interleukin (IL)-1beta.

Author(s): 
Deschner, J.
Rath-Deschner, B.
Agarwal, S.
Publication Title: 
The Journal of the American Osteopathic Association

CONTEXT: Normal physiologic movement, pathologic conditions, and osteopathic manipulative treatment (OMT) are believed to produce effects on the shape and proliferation of human fibroblasts. Studies of biophysically strained fibroblasts would be useful in producing a model of the cellular mechanisms underlying OMT.

Author(s): 
Dodd, John G.
Good, Meadow Maze
Nguyen, Tammy L.
Grigg, Andersen I.
Batia, Lyn M.
Standley, Paul R.

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